EKS-CII-00170

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00170

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	377.2	4.5E-113	572	831	260

Status

Unreviewed

Ensembl Protein

ENSCINP00000023911

UniProt Accession

F6RMP9;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000006493	ENSCINP00000023911	ENSCINT00000024157

Organism

Ciona intestinalis

Functional Description

Protein Length

831

Protein Sequence
(FASTA)

LSFSTVAHII ELVHSNQLIE LITLCRHALG MQSKRIRDSF LTSSTFHAPG TKGQYARLER 60

DEGDGAWCPS GYIQPDTIDQ YLQIDLPEPN FITNVATQGR YARGLGREYT SSYMLNYSRD 120

GETWFQWSNY QGVKKLQGNA DTNTVKRQML NPGVAAASHV RIIPVSTRTM SVCLRLELYG 180

CHWASGLVSY DIPAPMDSIA GQTNTRNTKY SDDTYDGTIS TNWFRNGLGQ LTDGVIGGND 240

LSQVGWSRSK SNDVTMTFRF ADVRNFTRMR NYPTQLKLYR LFTSVKVSFS LNGKTFPSTA 300

NARSLAYEVP KDAFDRTARF VDVPLRNSIA RYVRASFRIG DEYLLVSEVE FDNTTYNFKH 360

IVTLILTFPD VLPPSDAFRY PDEDVSNEPT VTPTVSNNLP VIIGSLLGVI GLLVFIVLGL 420

CYRQHRLRKK MVRYLFIFYV GPENIYSRVG EDGTTPLRYS YSRTSDNCGR SDHMVTLEPI 480

SRQSSSTGAG VVCSHNILSC TREVTRLLNQ PDVTMNTPNS SHYAESSIFL PSLEAQIGNT 540

SCIHHIFQFA DEMMSLMSLH GDKPPEFPRE KLEVVEQLGE GQFGEVQLCE LDEPVLVAVK 600

VLRADATSNA KEDFLKEVRV MSQMQDPNIV HLIAVCTNDE PYAMITEYME NGDLNQYLRS 660

CAVFSNEVLI NMCVQIASGM RYLSSHKFVH RDLATRNCLV DSNHSIRIAD FGMSRNMYQS 720

DYYRIQGRAV LPIRWMSWEC VLMGKFSSAS DAWAFGVTLW EIFSFCKLQP HNSLTDQQVI 780

ENMHHVFKRT GEEVHLQRPK RCPATLFNLI RQCWKRQPED RPTFEQLHGY L 831

Nucleotide Sequence
(FASTA)

CTATCGTTCT CCACAGTAGC ACACATCATA GAACTCGTAC ACAGTAACCA ACTTATCGAG 60

TTAATCACAC TGTGCCGCCA TGCGCTTGGA ATGCAAAGCA AGAGAATCCG AGATAGCTTT 120

CTTACTTCCT CCACCTTCCA TGCCCCTGGA ACTAAAGGAC AATACGCCAG ACTAGAAAGA 180

GACGAAGGCG ACGGCGCGTG GTGTCCATCG GGATACATAC AACCCGATAC AATTGATCAA 240

TATCTGCAGA TAGATCTACC GGAGCCCAAC TTTATAACGA ACGTTGCAAC GCAGGGAAGG 300

TACGCAAGGG GCTTAGGGCG TGAGTATACG TCCAGCTACA TGCTAAACTA CTCACGAGAC 360

GGCGAAACTT GGTTTCAGTG GTCAAACTAC CAAGGCGTAA AGAAACTTCA AGGAAATGCC 420

GACACAAACA CCGTAAAACG TCAAATGCTA AACCCCGGCG TCGCTGCTGC TAGCCATGTC 480

CGGATTATTC CAGTTTCAAC CAGAACGATG TCTGTATGCT TACGTCTCGA GCTTTATGGC 540

TGTCATTGGG CATCTGGATT GGTATCGTAT GACATACCTG CCCCAATGGA TAGCATTGCT 600

GGACAAACAA ACACCAGAAA CACAAAGTAT TCTGACGACA CGTACGACGG TACCATATCA 660

ACTAACTGGT TTCGAAACGG GCTCGGACAG TTGACTGATG GTGTGATTGG GGGCAACGAT 720

TTATCTCAGG TCGGTTGGTC CAGATCGAAA TCAAATGACG TCACCATGAC GTTTCGCTTT 780

GCTGACGTCA GGAACTTTAC CAGAATGCGA AATTACCCAA CGCAACTTAA ACTTTACAGG 840

CTATTCACGT CCGTAAAAGT GTCGTTCAGT CTTAACGGAA AAACATTTCC AAGCACTGCT 900

AATGCTCGCA GCCTCGCTTA CGAGGTGCCG AAAGATGCTT TCGATCGTAC AGCACGGTTC 960

GTGGATGTAC CTTTGCGAAA CTCAATAGCA AGATATGTTC GCGCCTCCTT TCGTATTGGG 1020

GACGAATATC TTCTGGTTAG CGAAGTCGAA TTCGATAACA CGACTTATAA TTTCAAACAT 1080

ATTGTGACTT TAATCCTCAC ATTTCCAGAC GTATTACCAC CGAGCGATGC TTTTCGTTAT 1140

CCCGACGAAG ATGTTTCTAA CGAGCCAACT GTAACACCCA CGGTGTCCAA CAACCTACCT 1200

GTTATCATAG GAAGTCTGCT TGGTGTTATT GGGCTGTTGG TCTTCATAGT GCTTGGTCTC 1260

TGCTATAGAC AGCATAGACT TCGTAAGAAA ATGGTGAGAT ATCTGTTTAT ATTCTATGTG 1320

GGACCTGAGA ACATATACAG TAGGGTGGGG GAAGACGGGA CAACACCACT GAGGTATTCG 1380

TACAGTAGAA CCAGCGACAA CTGCGGACGC TCAGACCACA TGGTGACATT AGAACCAATA 1440

TCGAGGCAAT CTTCATCCAC TGGTGCAGGG GTTGTTTGTT CGCACAACAT ATTAAGTTGC 1500

ACCCGCGAAG TTACACGTCT TCTCAACCAA CCTGACGTCA CAATGAACAC CCCGAATTCG 1560

TCACACTACG CGGAGTCCAG CATTTTTCTG CCATCTCTGG AAGCTCAGAT AGGAAATACA 1620

AGTTGTATTC ATCATATATT TCAATTTGCA GACGAAATGA TGAGCCTTAT GTCTCTGCAT 1680

GGTGATAAGC CGCCCGAGTT TCCTCGTGAG AAGCTGGAAG TAGTTGAGCA GTTAGGAGAG 1740

GGCCAGTTCG GTGAAGTACA GCTCTGTGAA TTGGACGAAC CAGTTTTGGT GGCGGTGAAA 1800

GTCTTACGTG CAGATGCAAC TTCAAATGCG AAAGAAGACT TCTTGAAAGA AGTTCGAGTA 1860

ATGAGCCAAA TGCAAGACCC GAACATTGTC CATCTTATTG CGGTGTGTAC GAACGACGAA 1920

CCATACGCCA TGATAACTGA GTACATGGAG AATGGGGATT TGAACCAATA CCTTCGTTCC 1980

TGCGCTGTTT TTAGCAATGA AGTTCTAATC AACATGTGTG TGCAAATCGC ATCAGGAATG 2040

CGTTACTTAT CCTCCCACAA GTTCGTGCAT CGTGACCTGG CAACCAGGAA CTGCTTGGTT 2100

GATTCGAATC ATTCTATCCG TATCGCTGAC TTTGGAATGT CGCGGAACAT GTATCAGAGT 2160

GATTATTACC GAATACAAGG CCGAGCAGTC CTCCCTATTC GCTGGATGTC GTGGGAGTGC 2220

GTTCTCATGG GCAAGTTCAG CAGTGCGAGT GACGCCTGGG CGTTTGGTGT TACACTTTGG 2280

GAAATCTTTT CTTTCTGTAA ACTACAGCCT CACAACTCCC TCACTGACCA ACAAGTGATT 2340

GAAAACATGC ATCACGTTTT CAAACGCACT GGGGAAGAGG TTCATTTGCA ACGACCAAAA 2400

CGCTGCCCTG CTACTCTGTT TAACTTAATC CGCCAATGTT GGAAGCGACA ACCTGAAGAC 2460

CGGCCAACCT TTGAACAACT ACATGGATAC TTA 2493

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekdskgsallvavkslredanknarkdflkeik  60

         L ++e+lGeG+fgev+lCe+++            ++lvavk+lr+da++na++dflke++

Q: 572   LEVVEQLGEGQFGEVQLCELDE------------PVLVAVKVLRADATSNAKEDFLKEVR  619

         6789****************99............9*************************

S: 61    ilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaedselakektlsyell  120

         ++s+++dPniv+l++vc++dep+ +i+ey+enGdlnq+l           + +  s e+l

Q: 620   VMSQMQDPNIVHLIAVCTNDEPYAMITEYMENGDLNQYL----------RSCAVFSNEVL  669

         ***************************************..........455678899**

S: 121   vsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdyyrvqGra  180

         ++++ qiasg++yL+s +fvhrdlatrnclv+ + +++iadfg+sr++y +dyyr+qGra

Q: 670   INMCVQIASGMRYLSSHKFVHRDLATRNCLVDSNHSIRIADFGMSRNMYQSDYYRIQGRA  729

         ************************************************************

S: 181   vlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvienagelfrd  240

         vlPiRwm+we++l+gkf+ asD+Wafgvtlwei+++c+ qP++ ltd+qvien+ ++f+

Q: 730   VLPIRWMSWECVLMGKFSSASDAWAFGVTLWEIFSFCKLQPHNSLTDQQVIENMHHVFKR  789

         ************************************************************

S: 241   qkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

          +++v l+rP+ cp +l++l+ +Cw+r+ ++RP+fe+lh +l

Q: 790   TGEEVHLQRPKRCPATLFNLIRQCWKRQPEDRPTFEQLHGYL  831

         ***************************************876

Domain Sequence
(FASTA)

LEVVEQLGEG QFGEVQLCEL DEPVLVAVKV LRADATSNAK EDFLKEVRVM SQMQDPNIVH 60

LIAVCTNDEP YAMITEYMEN GDLNQYLRSC AVFSNEVLIN MCVQIASGMR YLSSHKFVHR 120

DLATRNCLVD SNHSIRIADF GMSRNMYQSD YYRIQGRAVL PIRWMSWECV LMGKFSSASD 180

AWAFGVTLWE IFSFCKLQPH NSLTDQQVIE NMHHVFKRTG EEVHLQRPKR CPATLFNLIR 240

QCWKRQPEDR PTFEQLHGYL 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0007155	; P:cell adhesion

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013