EKS-CII-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	386.9	3.8E-116	144	410	267

Status

Unreviewed

Ensembl Protein

ENSCINP00000013966

UniProt Accession

F6UN86;

Protein Name

Protein Synonyms/Alias

Gene Name

rtkX

Gene Synonyms/Alias

rtkX;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000006805	ENSCINP00000013966	ENSCINT00000013966

Organism

Ciona intestinalis

Functional Description

Protein Length

477

Protein Sequence
(FASTA)

RNIKSNSYAK RTHFLHVVPQ EAQDIGNLLN VTVHLGRNIL YNPGVMDTTP PPKPVSIAAI 60

IVPVLLGIIV ILVVVMIIVC KRRNKKEETA VAYSANPVNN YHGNSIRNNE RLPLISSASI 120

SEQLSPQILQ EMSSVLISRN KLMVDKENII GKGHFGTVYN GEYITSEISK LNGNPIKRKV 180

AIKTLSKIED TESVEKFLKE GLMMSDFHDE NVLTLIGISW DDDGAPMVVL PYMMHGDLLQ 240

FIRKPSNNPT VKDLVGFGLQ ACKGMCYLAS QRFVHRDLAA RNCMLNETYV VKVADFGLAR 300

DIYEKEYYKP HEHAGRMPVK WMALESLQQQ TFTIKTDVWS FGILLWELLT RGVTPYPDVD 360

AFDVVNYILD GRRLRQPQYC PDPLYELMLS CWHPLPETRP DFVTLVRKIE QIYGEIHGVH 420

YPGSQSYNYC LDVNYINVMD VHPYPSLVRT SESRSTGGSM VQDVFSWSVK KTISHKS 477

Nucleotide Sequence
(FASTA)

AGAAATATAA AATCAAACTC GTACGCCAAA CGAACACATT TTTTACATGT AGTTCCACAA 60

GAAGCACAAG ATATAGGAAA TCTACTCAAT GTAACGGTTC ATCTTGGAAG AAACATCCTA 120

TACAACCCAG GTGTAATGGA CACCACTCCA CCACCAAAAC CTGTATCAAT CGCAGCAATC 180

ATTGTGCCTG TACTTCTAGG GATAATTGTA ATTCTTGTTG TGGTCATGAT AATTGTGTGC 240

AAGCGTAGAA ATAAGAAAGA AGAGACTGCT GTTGCCTACT CTGCCAATCC TGTGAACAAT 300

TACCATGGCA ACAGCATAAG AAACAATGAG CGTCTTCCCC TGATCAGTTC CGCTTCCATC 360

TCAGAGCAAC TTTCGCCACA AATCCTCCAA GAGATGAGTT CTGTGTTGAT ATCACGCAAC 420

AAGTTAATGG TTGACAAGGA GAATATTATA GGCAAAGGCC ATTTTGGGAC AGTGTACAAT 480

GGTGAATACA TCACCTCGGA GATAAGTAAA CTGAATGGGA ATCCCATTAA AAGAAAAGTG 540

GCGATCAAAA CCCTTTCAAA AATTGAAGAC ACAGAATCTG TGGAAAAGTT TCTTAAAGAA 600

GGTTTAATGA TGAGCGATTT TCACGATGAA AACGTCCTCA CGCTCATCGG GATCAGTTGG 660

GATGATGACG GAGCTCCAAT GGTTGTCCTC CCGTACATGA TGCACGGAGA TCTACTTCAG 720

TTTATACGAA AACCATCCAA CAATCCTACA GTAAAGGATC TGGTTGGGTT TGGGTTGCAA 780

GCATGCAAGG GGATGTGTTA TCTTGCATCA CAACGATTTG TTCATCGAGA TTTAGCTGCA 840

AGGAACTGTA TGTTGAATGA GACATATGTT GTGAAGGTGG CAGACTTTGG TTTGGCACGT 900

GATATTTACG AGAAGGAGTA TTACAAGCCA CACGAACATG CTGGAAGGAT GCCTGTTAAG 960

TGGATGGCAC TTGAGAGTCT TCAACAGCAA ACTTTCACCA TCAAGACCGA TGTCTGGTCA 1020

TTTGGTATTT TACTGTGGGA GCTTTTGACT AGAGGTGTCA CGCCTTATCC AGATGTGGAT 1080

GCGTTCGATG TTGTCAACTA CATACTTGAC GGACGTCGTT TACGTCAGCC ACAGTATTGC 1140

CCGGATCCTT TGTATGAACT CATGCTCAGT TGTTGGCATC CGTTGCCTGA AACAAGACCA 1200

GATTTTGTGA CGCTTGTACG AAAAATCGAG CAAATATATG GAGAAATACA TGGGGTGCAT 1260

TATCCAGGTA GCCAATCATA TAATTACTGT CTCGATGTGA ACTACATAAA TGTAATGGAT 1320

GTTCATCCTT ACCCATCACT GGTTCGAACA TCAGAAAGCA GAAGCACGGG TGGTAGCATG 1380

GTACAAGATG TCTTCTCCTG GTCTGTTAAA AAAACAATTT CGCACAAATC TTAA 1434

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsask.......kikvavksleritdiekveeflreglv  53

         vdke++iGkGhfG+vy+ge++ s+         k kva+k+l++i d+e ve+fl+egl+

Q: 144   VDKENIIGKGHFGTVYNGEYITSEISklngnpiKRKVAIKTLSKIEDTESVEKFLKEGLM  203

         7899****************9876431122222679************************

S: 54    mkeldhpnvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvak  113

         m++++  nvl+l+Gi+ dd+g p+vvlpym +Gdl +fir++++n+tvkdl++f+lq  k

Q: 204   MSDFHDENVLTLIGISWDDDGAPMVVLPYMMHGDLLQFIRKPSNNPTVKDLVGFGLQACK  263

         ************************************************************

S: 114   gmeylaskkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwl  173

         gm ylas++fvhrdlaarnc+l+e+++vkvadfGlard+++ke+y  +e+ + r+pvkw+

Q: 264   GMCYLASQRFVHRDLAARNCMLNETYVVKVADFGLARDIYEKEYYKPHEHAG-RMPVKWM  322

         **********************************************999998.*******

S: 174   aleslqtfkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycp  233

         aleslq++  ft+k+dvwsfG+llwelltrg tpy++v++fd++ y+ +grrlr+p+ycp

Q: 323   ALESLQQQT-FTIKTDVWSFGILLWELLTRGVTPYPDVDAFDVVNYILDGRRLRQPQYCP  381

         ******999.**************************************************

S: 234   dklydvmlkcwkakpaerpqfsdlvsiis  262

         d ly++ml+cw++ p++rp+f+ lv +i

Q: 382   DPLYELMLSCWHPLPETRPDFVTLVRKIE  410

         *************************9885

Domain Sequence
(FASTA)

VDKENIIGKG HFGTVYNGEY ITSEISKLNG NPIKRKVAIK TLSKIEDTES VEKFLKEGLM 60

MSDFHDENVL TLIGISWDDD GAPMVVLPYM MHGDLLQFIR KPSNNPTVKD LVGFGLQACK 120

GMCYLASQRF VHRDLAARNC MLNETYVVKV ADFGLARDIY EKEYYKPHEH AGRMPVKWMA 180

LESLQQQTFT IKTDVWSFGI LLWELLTRGV TPYPDVDAFD VVNYILDGRR LRQPQYCPDP 240

LYELMLSCWH PLPETRPDFV TLVRKIE 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013