EKS-CII-00260
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CII-00260
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK428.96.8E-12921309289
StatusUnreviewed
Ensembl ProteinENSCINP00000014552
UniProt AccessionQ4H3L5; F6W926;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase;
Gene NameCi-ERK1/2
Gene Synonyms/Alias Ci-ERK1/2; erk1/2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCING00000007067ENSCINP00000014552ENSCINT00000014552
OrganismCiona intestinalis
Functional Description
Protein Length350
Protein Sequence
(FASTA)
MSDKRPPEVV RGQVFDVAPR YTSLSYIGEG AYGMVCSATD GQNGQKVAIK KISPFEHQTY 60
CQRTLREIRI LISFNHENII SIKDIIRAPT LAEMKDVYIV QDLMETDLYK LLKTQHLSND 120
HICYFLYQIL RGLKYIHSAN VIHRDLKPSN LLLNTTCDLK ICDFGLARVA DPEHDHTGFL 180
TEYVATRWYR APEIMLNSKG YTKSIDIWSV GCILAEMISN RPIFPGKHYL DQLNHILGIL 240
GSPSEEDLNC IINEKARAYL MSLPNKPRLS WSRLYSKADE KALDLLDRML TFNPTKRINV 300
DDALAHPYLE QYYDPADEPV TEKPFTFEEE FDDLPKERLK ELIFQVSPCR 350
Nucleotide Sequence
(FASTA)
ATGTCGGACA AGCGACCTCC CGAAGTTGTT CGAGGACAAG TTTTTGATGT TGCTCCACGC 60
TATACAAGTC TGAGCTACAT TGGAGAGGGG GCATATGGCA TGGTTTGTTC TGCGACTGAT 120
GGTCAGAACG GTCAGAAAGT GGCGATCAAA AAAATCAGTC CATTTGAGCA CCAGACATAC 180
TGTCAACGTA CATTGCGTGA GATAAGAATA TTGATCTCAT TCAACCACGA GAACATTATC 240
TCCATAAAGG ATATCATAAG AGCTCCCACA CTTGCAGAAA TGAAAGATGT CTACATCGTT 300
CAAGATCTTA TGGAAACTGA TTTATATAAG CTGTTGAAAA CTCAACATTT GAGTAACGAC 360
CATATCTGCT ATTTCTTGTA CCAGATTTTA CGAGGATTAA AATATATTCA CTCAGCGAAT 420
GTAATCCATA GGGATTTAAA ACCCAGCAAT TTGCTTCTGA ACACAACTTG TGATTTAAAG 480
ATTTGCGACT TTGGTTTGGC GAGAGTTGCC GACCCCGAGC ACGACCACAC GGGGTTCCTC 540
ACTGAGTACG TCGCCACCCG ATGGTACAGA GCTCCCGAAA TCATGCTCAA TTCGAAGGGG 600
TATACAAAAT CAATTGATAT TTGGTCTGTC GGATGCATTC TGGCTGAAAT GATTAGTAAC 660
AGACCAATTT TTCCTGGAAA ACACTATTTG GATCAGCTTA ATCACATTTT AGGCATCCTT 720
GGCTCCCCAT CAGAAGAGGA CCTCAACTGC ATCATCAATG AGAAAGCTCG TGCTTATCTT 780
ATGTCTCTGC CGAACAAGCC ACGCCTCTCT TGGTCTCGTC TCTACTCAAA AGCTGACGAA 840
AAAGCGCTTG ACCTTTTGGA CCGTATGCTG ACCTTCAACC CCACCAAGCG TATTAACGTC 900
GACGACGCTC TTGCTCACCC TTATCTTGAG CAATATTACG ACCCAGCTGA CGAACCCGTG 960
ACAGAGAAAC CCTTCACTTT TGAAGAGGAA TTTGATGACC TGCCGAAAGA ACGACTGAAG 1020
GAACTTATTT TCCAGGTCTC CCCATGCCGT TGA 1053
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y+sl+++geGayg+v+sa+d +++++vaikk+s pf+++t ++rtlRE+++l +++heNi
Q: 21    YTSLSYIGEGAYGMVCSATDGQNGQKVAIKKIS-PFEHQTYCQRTLREIRILISFNHENI  79
         78899***************************9.**************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i++ d++++ + l e+kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs
Q: 80    ISIKDIIRAPT-LAEMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  138
         *********99.************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178
         anviHrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++
Q: 139   ANVIHRDLKPSNLLLNTTCDLKICDFGLARVADPEHDHTgfLTEYVATRWYRAPEIMLNS  198
         ***********************************99999********************
S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238
         k ytk++DiWsvGCIlaE+++++p+fpgk+++dql++il +lg+psee+l++i +e+ar+
Q: 199   KGYTKSIDIWSVGCILAEMISNRPIFPGKHYLDQLNHILGILGSPSEEDLNCIINEKARA  258
         ************************************************************
S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         y+ slp+k++ ++++l++ka+e+aldLl+++L+++p+kRi+v++aL+hpYl
Q: 259   YLMSLPNKPRLSWSRLYSKADEKALDLLDRMLTFNPTKRINVDDALAHPYL  309
         **************************************************7
Domain Sequence
(FASTA)
YTSLSYIGEG AYGMVCSATD GQNGQKVAIK KISPFEHQTY CQRTLREIRI LISFNHENII 60
SIKDIIRAPT LAEMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120
VIHRDLKPSN LLLNTTCDLK ICDFGLARVA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180
YTKSIDIWSV GCILAEMISN RPIFPGKHYL DQLNHILGIL GSPSEEDLNC IINEKARAYL 240
MSLPNKPRLS WSRLYSKADE KALDLLDRML TFNPTKRINV DDALAHPYL 289
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00435
EKS-ANC-00450
EKS-BOT-00462
EKS-CAE-00385
EKS-CAJ-00466
EKS-CAF-00460
EKS-CAP-00493
EKS-CIS-00220
EKS-DAR-00868
EKS-DAN-00034
EKS-DIO-00097
EKS-DRM-00222
EKS-ECT-00060
EKS-EQC-00449
EKS-ERE-00049
EKS-FEC-00439
EKS-GAM-00267
EKS-GAG-00389
EKS-GAA-00558
EKS-GOG-00450
EKS-HOS-00469
EKS-ICT-00441
EKS-LAC-00473
EKS-LOA-00473
EKS-MAM-00459
EKS-MAE-00072
EKS-MEG-00382
EKS-MIM-00088
EKS-MOD-00452
EKS-MUM-00494
EKS-MUP-00452
EKS-MYL-00457
EKS-NOL-00423
EKS-OCP-00120
EKS-ORN-00584
EKS-ORA-00408
EKS-ORC-00440
EKS-ORL-00529
EKS-OTG-00474
EKS-PAT-00435
EKS-PES-00410
EKS-PEM-00252
EKS-POA-00449
EKS-PTV-00167
EKS-RAN-00476
EKS-SAH-00430
EKS-SUS-00410
EKS-TAG-00529
EKS-TAR-00574
EKS-TAS-00069
EKS-TEN-00572
EKS-TUT-00168
EKS-XIM-00573
EKS-SAC-00100
EKS-SCP-00101
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
cin:778596;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013