EKS-CII-00086

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00086

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	466.2	2.6E-140	177	434	258

Status

Unreviewed

Ensembl Protein

ENSCINP00000016461

UniProt Accession

F6S4F7;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100181308

Gene Synonyms/Alias

LOC100181308;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000008043	ENSCINP00000016461	ENSCINT00000016461

Organism

Ciona intestinalis

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MSDTTTGPSM ASIVKEGWLQ KRGEYIRNWR RRYFVLKTDG SFLGYKDKPD PDNHQEPLNN 60

FSVLKSQVMR KDQQRENAFV FVVRCLQWTT IIERTFTSTS KVDREEWMKA IEGVSDQLQH 120

SPEEKSVTED ESKKTSDHKV INTVCENTFN KHANPLIKQP ENEFIKPAKS NKTLTDFEFL 180

EVLGKGTFGK VILVKEKKTE EFHAMKILKK EVIVAKDEVT HTLTENRVLQ QTRHPFLTSL 240

KYSFQTNDYL CFVMEYVNGG EIFFHLSRDR VFSEDRARFY GAEIILALDY LHQQEVIYRD 300

LKLENLLLDS EGHIKITDFG LCKEEIRFGT TTKTFCGTPE YLAPEVLEDN DYGRSVDWWG 360

LGVVMYEMMC GRLPFYNRDH DVLFELILMD DLRFPSGLSK EGKSLLSELL NKDPLKRLGS 420

SQSDAQEVMA HRFFSAVVWK DILEKKVPPP FKPQVSSITD TRYFDKEFTA QPVQLTPPDQ 480

SSSMDDTNRP HFEAFSYSSS GSHLDKGSRN HR 512

Nucleotide Sequence
(FASTA)

ATGTCAGACA CCACCACAGG TCCATCAATG GCATCCATTG TGAAGGAAGG ATGGCTCCAA 60

AAAAGAGGTG AATACATAAG GAACTGGAGA CGAAGATATT TTGTTCTAAA AACAGATGGA 120

TCTTTTCTTG GTTATAAAGA TAAACCTGAT CCAGACAATC ATCAAGAACC GCTCAATAAC 180

TTTAGTGTTT TAAAATCCCA GGTCATGAGG AAAGACCAGC AACGTGAAAA CGCATTTGTG 240

TTCGTTGTAC GATGTTTACA ATGGACCACT ATCATTGAAC GTACCTTCAC ATCCACATCA 300

AAAGTTGACA GAGAAGAATG GATGAAAGCC ATTGAAGGAG TCAGTGATCA ACTTCAGCAT 360

TCTCCGGAGG AAAAAAGTGT CACAGAAGAT GAGTCAAAGA AGACATCCGA TCACAAAGTG 420

ATTAACACAG TTTGTGAGAA TACCTTTAAC AAACATGCTA ATCCATTAAT TAAGCAACCT 480

GAAAATGAAT TCATCAAACC AGCCAAGAGC AACAAGACCT TGACTGACTT CGAGTTCTTA 540

GAAGTTCTTG GAAAAGGAAC TTTTGGTAAA GTAATTCTCG TAAAAGAGAA GAAAACCGAA 600

GAATTTCACG CCATGAAAAT TTTGAAGAAA GAAGTTATTG TTGCTAAGGA TGAAGTCACA 660

CACACACTCA CTGAAAACCG AGTTCTACAG CAGACCAGGC ATCCATTTTT AACGTCGTTA 720

AAATACTCAT TTCAAACCAA TGACTACTTA TGCTTTGTTA TGGAGTATGT GAATGGTGGA 780

GAGATTTTCT TCCATTTATC ACGGGATCGT GTGTTCAGTG AAGACAGAGC AAGATTCTAC 840

GGAGCAGAAA TAATTTTGGC TCTTGATTAT TTGCATCAAC AAGAAGTTAT TTACAGAGAT 900

CTTAAACTAG AAAACTTGTT GTTGGACAGT GAAGGACATA TCAAGATTAC AGATTTTGGG 960

TTATGTAAGG AAGAGATTAG ATTTGGAACA ACAACTAAAA CATTCTGTGG AACACCAGAA 1020

TACCTTGCAC CAGAGGTCCT TGAAGATAAT GATTACGGTC GGTCAGTGGA TTGGTGGGGG 1080

CTTGGTGTAG TGATGTATGA GATGATGTGT GGTAGACTTC CATTCTATAA TCGGGATCAT 1140

GATGTTCTAT TTGAACTTAT TCTCATGGAT GACCTGAGGT TTCCATCAGG TTTATCAAAA 1200

GAAGGCAAAA GTTTGTTATC AGAACTACTG AACAAGGATC CCTTGAAAAG ATTGGGTAGT 1260

AGTCAAAGTG ATGCACAAGA AGTAATGGCT CACAGATTCT TCTCAGCTGT TGTTTGGAAA 1320

GATATCTTGG AGAAAAAGGT TCCCCCACCT TTCAAACCTC AAGTTTCCTC CATAACTGAC 1380

ACGCGATATT TTGACAAAGA ATTCACTGCA CAACCTGTTC AACTAACACC ACCTGATCAG 1440

TCATCGTCCA TGGATGACAC CAACCGACCT CATTTCGAGG CGTTCTCTTA CTCCTCTAGT 1500

GGCAGCCACT TAGATAAGGG GAGCAGAAAC CATCGATAA 1539

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         f++l +lGkGtfGkvilv+ek+t+ ++a+kilkkevivakdev+htlte+rvl++t+hpf

Q: 177   FEFLEVLGKGTFGKVILVKEKKTEEFHAMKILKKEVIVAKDEVTHTLTENRVLQQTRHPF  236

         99**********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqt++ lc+v+eyvnGGe+ffhls+ rvfsedrarfygaei++aldylh+++v

Q: 237   LTSLKYSFQTNDYLCFVMEYVNGGEIFFHLSRDRVFSEDRARFYGAEIILALDYLHQQEV  296

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         +yrdlklenllld +GhikitdfGlckeei++g +tktfcGtpeylapevled+dyg++v

Q: 297   IYRDLKLENLLLDSEGHIKITDFGLCKEEIRFGTTTKTFCGTPEYLAPEVLEDNDYGRSV  356

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dh+ lfelil+++l+fp+ ls+e+kslls ll+kdp k

Q: 357   DWWGLGVVMYEMMCGRLPFYNRDHDVLFELILMDDLRFPSGLSKEGKSLLSELLNKDPLK  416

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlG+ ++da+e+++h+ff

Q: 417   RLGSSQSDAQEVMAHRFF  434

         *****************9

Domain Sequence
(FASTA)

FEFLEVLGKG TFGKVILVKE KKTEEFHAMK ILKKEVIVAK DEVTHTLTEN RVLQQTRHPF 60

LTSLKYSFQT NDYLCFVMEY VNGGEIFFHL SRDRVFSEDR ARFYGAEIIL ALDYLHQQEV 120

IYRDLKLENL LLDSEGHIKI TDFGLCKEEI RFGTTTKTFC GTPEYLAPEV LEDNDYGRSV 180

DWWGLGVVMY EMMCGRLPFY NRDHDVLFEL ILMDDLRFPS GLSKEGKSLL SELLNKDPLK 240

RLGSSQSDAQ EVMAHRFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013