EPS-CII-00009

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CII-00009

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	243.0	3.7E-72	24	292	269

Status

Unreviewed

Ensembl Protein

ENSCINP00000016638

UniProt Accession

F6VFZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100183363

Gene Synonyms/Alias

LOC100183363;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000008148	ENSCINP00000016638	ENSCINT00000016638

Organism

Ciona intestinalis

Functional Description

Protein Length

412

Protein Sequence
(FASTA)

MGAFLDKPKI EKQTERGHGN DLEYAVSSMQ GWRVDMEDSH TAKLSLPGLP QWSFFAVFDG 60

HAGSKVAEHS SEHLLDNILT HANFKKIIEA SEKGKQEDEK MVKKAIVDSF LQFDQKMRNI 120

TDSKTGFDRS GSTSVCVLIS PTRYYFINCG DSRGLLCRQG AVHFATVDHK PFNPLERERI 180

QNAGGNVLIQ RVNGSLAVSR ALGDYEYKNV EDKSQTEQLV SPEPDVTCIE RLTKQDEFII 240

LACDGIFDVS SDEELTNYVK SRLAITEDLV SVCNDVVDMS LNKGSRDNMT LVLLALPSIP 300

KPNDKAKEEE AKLDEQLRSL MKEACDEVKN TRGDNMDFSL VLQTLVGDES KIQGLPPGGG 360

IYSKRAFLEK VYKELYPETE ALVSSGFSSS VDIDLNLETN ETNGNEMTDS GV 412

Nucleotide Sequence
(FASTA)

ATGGGGGCGT TCTTGGATAA ACCAAAGATT GAAAAGCAGA CCGAGCGTGG ACATGGGAAT 60

GATTTAGAAT ATGCAGTGAG TAGCATGCAG GGGTGGAGGG TTGATATGGA AGATAGCCAC 120

ACTGCTAAGT TGTCTCTACC TGGCCTCCCA CAGTGGTCGT TCTTTGCTGT TTTCGACGGC 180

CATGCAGGCT CGAAAGTTGC CGAACATTCG TCCGAGCACC TGTTAGACAA CATACTAACG 240

CACGCAAACT TTAAGAAGAT TATCGAAGCT TCAGAAAAGG GTAAACAGGA AGATGAAAAG 300

ATGGTCAAAA AAGCGATTGT CGATTCTTTT CTTCAGTTCG ATCAAAAAAT GCGAAACATC 360

ACCGATTCGA AGACCGGTTT CGACCGCAGT GGTTCCACTT CAGTGTGTGT TCTTATCTCA 420

CCCACCCGAT ACTACTTCAT TAATTGCGGC GACTCTAGAG GCTTACTGTG CCGACAAGGT 480

GCCGTCCATT TTGCCACTGT CGACCACAAA CCATTCAACC CATTGGAGCG AGAACGAATC 540

CAAAATGCTG GCGGTAACGT CCTAATACAG CGCGTCAACG GCTCTCTTGC TGTGTCGCGT 600

GCTCTTGGCG ATTACGAGTA CAAAAACGTG GAAGATAAAT CTCAAACTGA ACAATTAGTC 660

TCGCCAGAAC CAGACGTTAC CTGCATCGAA CGGTTAACTA AACAAGACGA ATTTATAATT 720

TTAGCTTGTG ACGGAATTTT TGATGTTTCG AGCGATGAAG AATTAACGAA TTATGTCAAG 780

TCAAGGTTAG CCATCACAGA AGATCTTGTT TCAGTGTGCA ATGATGTCGT TGACATGAGC 840

TTAAATAAGG GGAGCCGAGA CAACATGACC CTAGTATTGC TGGCTCTCCC ATCTATTCCT 900

AAACCAAATG ATAAAGCAAA AGAAGAAGAA GCAAAGTTGG ATGAACAACT AAGATCACTC 960

ATGAAAGAGG CTTGTGATGA AGTAAAGAAC ACACGAGGAG ACAACATGGA TTTCTCGCTT 1020

GTGCTTCAAA CCCTCGTTGG CGATGAGAGC AAAATACAAG GCCTACCTCC TGGGGGAGGA 1080

ATTTACTCAA AGCGAGCTTT CCTGGAGAAA GTTTACAAAG AACTTTACCC AGAAACTGAG 1140

GCCCTTGTGA GTTCTGGTTT CAGCAGCTCT GTGGACATCG ACTTAAATTT AGAAACTAAT 1200

GAAACAAATG GAAATGAAAT GACAGATTCA GGTGTGTAA 1239

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         + v+s++g+r +med++t++ ++   p+    ++ff+v+DGh+gs+va+  se+l + +

Q: 24    YAVSSMQGWRVDMEDSHTAKLSLPGLPQ----WSFFAVFDGHAGSKVAEHSSEHLLDNIL  79

         7899*************98666555554....9*************************99

S: 63    eele..........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +  +           ++++e+ vkka+ ++Fl++d++++++ + ++  d+sGst v++li

Q: 80    THANfkkiieasekGKQEDEKMVKKAIVDSFLQFDQKMRNITDSKTGFDRSGSTSVCVLI  139

         999999999999876677888899**************9999999***************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++ +y++n+GdSr +Lcr+g ++  ++dHkp ++ E+eRi++agg+v  +   Rv+G+L

Q: 140   SPTRYYFINCGDSRGLLCRQGAVHFATVDHKPFNPLERERIQNAGGNVLIQ---RVNGSL  196

         **************************************************9...******

S: 173   avsRalGdlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeav  222

         avsRalGd+++k         ++v+peP+vt +++ t++def+iLa+DG++dv s+ee+

Q: 197   AVSRALGDYEYKnvedksqteQLVSPEPDVTCIERlTKQDEFIILACDGIFDVSSDEELT  256

         ********************************9888************************

S: 223   slvrdvlekkeaeqeaakkLvklalargskdnvsai  258

         ++v+++l  +e++ ++++ +v+++l++gs+dn++ +

Q: 257   NYVKSRLAITEDLVSVCNDVVDMSLNKGSRDNMTLV  292

         *********************************766

Domain Sequence
(FASTA)

YAVSSMQGWR VDMEDSHTAK LSLPGLPQWS FFAVFDGHAG SKVAEHSSEH LLDNILTHAN 60

FKKIIEASEK GKQEDEKMVK KAIVDSFLQF DQKMRNITDS KTGFDRSGST SVCVLISPTR 120

YYFINCGDSR GLLCRQGAVH FATVDHKPFN PLERERIQNA GGNVLIQRVN GSLAVSRALG 180

DYEYKNVEDK SQTEQLVSPE PDVTCIERLT KQDEFIILAC DGIFDVSSDE ELTNYVKSRL 240

AITEDLVSVC NDVVDMSLNK GSRDNMTLV 269

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

cin:100183363

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013