EKS-CII-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	465.8	3.6E-140	323	581	259

Status

Unreviewed

Ensembl Protein

ENSCINP00000017438

UniProt Accession

F6XQ16;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

prkca

Gene Synonyms/Alias

prkca;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000008551	ENSCINP00000017438	ENSCINT00000017438

Organism

Ciona intestinalis

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MSEETAFKGF ARQGALRQKV HKVKSHEFIP RFFKQPTFCS HCTAFVWGFG KQGYQCQICR 60

LVVHKRCHEF VAFECPGVQN DTCHTQHKFR VASYGSPTFC DHCGSLLYGL VRQGMKCTSC 120

NLNFHKRCIR NVPALCGKDN TEKRGRIHLN CHIVDGKLAV SATVQQGKNL APMDPNGLSD 180

PYVKVKLIPA LKNDSKTLKR KTTIVEKSLN PHWNEVLVIP LKDADKDRRL LVEVWDWDRA 240

SSNDFMGSLS FGISELMKKS VKGWFKLLSQ QEGEFYNVPI VEEGEEMDAL TEELEKRNEE 300

KQRHAVNNKR PMKSSVQMAP SDFNFLHVLG RGSFGKVLLA ERKGTDEIFA IKVLKKDVIV 360

QDDDVECTMI EKKVLALPEK PPFLTQIHSC FQTNDRLYFV MEYINGGDLM YHIQQVGKFK 420

EPQATFYAAE IALGLFFLHD RGIVYRDLKL DNVMLDANGH IKIADFGMCK DDIIGDRTTN 480

TFCGTPDYIA PEIIVYEPYG KSVDWWAYGV LLYEMLAGQP PFDGEDEDEL FNSIMENCVS 540

YPRSMSKEAT AICKGFLQKH PSKRLGCSDD GQRAIKEHAF FRMLNWDRLA AREIQPPFKP 600

KIQSSNITEN FDKYFTRGEP KLTPIDPLFL KNINQDEFDG FSYVNVLFEP VTRSSLV 657

Nucleotide Sequence
(FASTA)

ATGAGCGAGG AAACCGCATT CAAAGGATTT GCAAGACAAG GAGCTTTAAG ACAGAAGGTG 60

CATAAAGTCA AGAGCCACGA ATTCATACCA AGATTTTTTA AACAACCAAC ATTCTGCAGT 120

CATTGCACTG CTTTTGTCTG GGGTTTTGGA AAACAAGGAT ACCAATGTCA AATTTGTCGA 180

TTGGTTGTCC ACAAACGTTG CCATGAGTTC GTTGCATTTG AATGTCCTGG TGTACAAAAT 240

GACACTTGCC ACACCCAGCA CAAGTTCCGA GTTGCTTCAT ATGGCTCTCC AACCTTTTGT 300

GATCATTGTG GATCACTGTT GTATGGTCTT GTTAGACAGG GGATGAAATG TACATCTTGC 360

AATCTGAATT TCCACAAGCG CTGTATTCGT AATGTACCAG CATTGTGTGG AAAGGATAAT 420

ACAGAGAAAC GAGGAAGGAT TCATCTTAAC TGTCATATTG TGGATGGGAA GTTGGCTGTG 480

TCCGCCACAG TTCAACAGGG CAAGAACCTT GCACCTATGG ATCCTAACGG ATTATCCGAT 540

CCTTATGTGA AAGTAAAGTT AATACCAGCG CTTAAAAATG ACTCCAAGAC CTTAAAGAGG 600

AAAACCACAA TTGTAGAGAA AAGTCTTAAC CCTCATTGGA ACGAAGTTCT TGTAATCCCA 660

CTTAAAGACG CGGACAAAGA TCGTCGGTTG TTGGTCGAGG TTTGGGATTG GGATCGAGCT 720

TCTTCCAATG ATTTTATGGG ATCTCTATCT TTCGGAATAT CAGAATTAAT GAAAAAATCA 780

GTTAAAGGAT GGTTTAAACT ACTCAGCCAA CAAGAAGGTG AATTCTACAA TGTTCCAATT 840

GTTGAGGAAG GTGAAGAGAT GGATGCTCTA ACTGAAGAAC TAGAGAAACG AAATGAGGAG 900

AAGCAGAGAC ACGCGGTGAA CAATAAGCGA CCTATGAAGT CATCGGTGCA AATGGCTCCT 960

TCAGATTTCA ACTTTCTGCA CGTACTTGGT CGGGGAAGTT TTGGAAAGGT ATTACTCGCT 1020

GAACGCAAAG GAACCGATGA GATATTCGCC ATCAAAGTCC TCAAGAAAGA TGTGATTGTG 1080

CAGGATGATG ATGTTGAATG TACCATGATC GAGAAGAAAG TCCTCGCTCT TCCTGAGAAA 1140

CCTCCGTTCC TCACACAGAT CCACTCCTGC TTCCAAACCA ATGATCGGTT GTACTTTGTA 1200

ATGGAATACA TCAATGGGGG AGATCTAATG TATCATATTC AACAAGTGGG AAAATTCAAG 1260

GAACCTCAAG CAACGTTCTA TGCTGCCGAG ATAGCACTCG GTTTGTTTTT CCTTCATGAC 1320

CGAGGCATCG TGTACAGAGA TCTTAAACTA GACAACGTGA TGCTTGATGC TAACGGACAC 1380

ATCAAGATCG CTGACTTCGG GATGTGTAAA GATGATATTA TAGGAGATAG AACAACCAAC 1440

ACATTCTGTG GAACACCTGA TTATATTGCA CCTGAGATTA TTGTGTATGA ACCTTATGGC 1500

AAGTCAGTTG ATTGGTGGGC TTATGGTGTC TTGCTATATG AGATGTTAGC TGGACAGCCC 1560

CCCTTTGATG GAGAAGATGA GGATGAATTA TTCAACTCAA TCATGGAGAA TTGTGTTTCT 1620

TACCCAAGGT CGATGTCCAA GGAGGCCACT GCTATTTGCA AGGGGTTCTT ACAGAAACAT 1680

CCATCAAAGA GACTTGGATG TAGTGATGAT GGGCAAAGAG CGATCAAGGA GCACGCATTC 1740

TTCCGGATGT TAAACTGGGA TCGATTAGCA GCTCGTGAAA TTCAACCTCC CTTCAAGCCA 1800

AAGATTCAGA GCAGCAACAT TACCGAAAAT TTCGACAAAT ACTTCACAAG GGGAGAACCA 1860

AAGTTAACCC CGATCGACCC CTTATTTTTG AAAAATATCA ACCAAGATGA GTTCGACGGA 1920

TTTTCTTACG TTAACGTTCT CTTTGAGCCT GTCACTAGAT CAAGTTTAGT T 1971

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlG+Gsfgkvllae+k+tde++aikvlkkdv++qdddve+t++ek+vlal +k+p

Q: 323   FNFLHVLGRGSFGKVLLAERKGTDEIFAIKVLKKDVIVQDDDVECTMIEKKVLALPEKPP  382

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+q++scfqt+drl+fv+ey+nGGdlm+hiq+++k+ke++a+fyaaei+l+l+flh++g

Q: 383   FLTQIHSCFQTNDRLYFVMEYINGGDLMYHIQQVGKFKEPQATFYAAEIALGLFFLHDRG  442

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldnv+lda+Ghik+adfG+ck++i+ ++tt+tfcGtPdyiaPei+ +e+ygks

Q: 443   IVYRDLKLDNVMLDANGHIKIADFGMCKDDIIGDRTTNTFCGTPDYIAPEIIVYEPYGKS  502

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e+ v+yP+s+skea++i+kg+l+k+p+

Q: 503   VDWWAYGVLLYEMLAGQPPFDGEDEDELFNSIMENCVSYPRSMSKEATAICKGFLQKHPS  562

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG++++g+++ikehaff

Q: 563   KRLGCSDDGQRAIKEHAFF  581

         ******************9

Domain Sequence
(FASTA)

FNFLHVLGRG SFGKVLLAER KGTDEIFAIK VLKKDVIVQD DDVECTMIEK KVLALPEKPP 60

FLTQIHSCFQ TNDRLYFVME YINGGDLMYH IQQVGKFKEP QATFYAAEIA LGLFFLHDRG 120

IVYRDLKLDN VMLDANGHIK IADFGMCKDD IIGDRTTNTF CGTPDYIAPE IIVYEPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFN SIMENCVSYP RSMSKEATAI CKGFLQKHPS 240

KRLGCSDDGQ RAIKEHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013