EKS-CII-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	393.8	3.6E-118	48	344	297

Status

Unreviewed

Ensembl Protein

ENSCINP00000018935

UniProt Accession

F6ZMT5;

Protein Name

Protein Synonyms/Alias

Gene Name

jnk

Gene Synonyms/Alias

jnk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000009313	ENSCINP00000018935	ENSCINT00000018935

Organism

Ciona intestinalis

Functional Description

Protein Length

437

Protein Sequence
(FASTA)

QADEGMSNGK NKGANAPTGA ATTGKDTANT EFYTVQVSDS VFTVLKRYQS LKPIGSGAQG 60

MVCAAHDTVL GQHVAIKKLS RPFQNPTHAK RAYRELVLMR AVNHKNIIGL LNVFSPQSSY 120

EDFSHVYLVM ELMDASLCQV IQMDLDHERL SYLLYQLLCG IKHLHSAGII HRDLKPSNIV 180

VRSDCTLKIL DFGLARTAGG SFMMTPYVVT RYYRAPEVIL GMGYQEVVDI WSVGCIFGEM 240

IRGQVLFPGN DHIDQWNKIT EQLGTPSEDF INKLQPTVRN YVLNRPFQRG HPIHRLFPDS 300

LFPADSESNG RLRSSQARDL LAKMLVVDPI GRITVDDALQ HPYIKIWYDP SEVEGPGPKV 360

DGGSIDEVDY SVEKWKEVIW TEVKLWDTVD TTVPNPVIPL STAVPDQPAE KLEPEKAESN 420

PDVPAATAQV VKAETEG 437

Nucleotide Sequence
(FASTA)

CAAGCAGATG AGGGCATGAG CAACGGTAAA AATAAAGGTG CTAATGCACC TACTGGTGCT 60

GCTACGACTG GCAAAGATAC AGCAAATACA GAGTTCTACA CTGTACAAGT ATCTGATTCT 120

GTCTTTACTG TACTTAAGAG ATATCAGAGC CTGAAACCAA TTGGTTCTGG TGCACAAGGA 180

ATGGTATGTG CCGCCCATGA TACAGTACTT GGCCAACATG TAGCCATAAA GAAACTCAGT 240

CGTCCGTTCC AAAATCCGAC ACATGCGAAG CGTGCCTACC GCGAGCTTGT CCTTATGCGC 300

GCTGTCAACC ACAAAAATAT CATCGGTTTA CTGAACGTTT TTTCACCCCA ATCTAGTTAT 360

GAAGATTTTT CCCATGTGTA TCTTGTCATG GAACTTATGG ATGCTAGTTT ATGCCAGGTG 420

ATTCAAATGG ATCTTGACCA CGAAAGACTC TCCTATCTTC TCTACCAGTT ACTTTGTGGC 480

ATTAAACACT TGCATTCTGC TGGTATCATT CACAGGGACT TAAAACCATC CAACATTGTA 540

GTACGGTCGG ACTGCACACT TAAAATTCTT GACTTTGGTT TGGCAAGAAC TGCAGGAGGT 600

TCTTTTATGA TGACGCCGTA TGTGGTGACA CGATATTACA GAGCACCAGA AGTGATTTTA 660

GGAATGGGGT ATCAAGAAGT AGTGGACATA TGGTCAGTGG GATGTATCTT TGGTGAAATG 720

ATTAGAGGTC AGGTCCTTTT TCCTGGAAAT GATCACATAG ATCAATGGAA TAAGATAACA 780

GAACAATTAG GAACTCCATC AGAGGACTTT ATCAACAAAC TGCAGCCAAC AGTGAGGAAT 840

TATGTTTTGA ATCGGCCATT CCAAAGAGGA CACCCAATTC ATCGCTTGTT CCCTGATAGT 900

CTCTTCCCAG CTGACTCCGA GAGCAATGGA AGACTCCGGT CAAGTCAGGC ACGCGATCTT 960

CTTGCTAAGA TGTTGGTAGT TGACCCAATT GGAAGAATTA CTGTTGATGA TGCACTGCAA 1020

CACCCATATA TTAAAATCTG GTACGATCCC AGCGAGGTAG AAGGCCCAGG TCCAAAAGTC 1080

GACGGCGGAT CAATAGACGA GGTCGATTAC TCGGTTGAAA AATGGAAAGA AGTAATTTGG 1140

ACAGAAGTAA AACTATGGGA CACAGTGGAC ACAACTGTCC CAAACCCGGT TATACCGCTC 1200

TCGACAGCTG TACCAGATCA ACCTGCTGAA AAACTCGAAC CCGAGAAGGC AGAGAGTAAC 1260

CCAGACGTGC CTGCTGCTAC TGCACAGGTT GTGAAAGCAG AAACGGAAGG ATAA 1314

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y+slkp+g+Ga+g+v++a d+  +++vaikklsrpfq+ t+akr++REl l++ ++h+Ni

Q: 48    YQSLKPIGSGAQGMVCAAHDTVLGQHVAIKKLSRPFQNPTHAKRAYRELVLMRAVNHKNI  107

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vf p++++e++++vYlv+elm++ L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 108   IGLLNVFSPQSSYEDFSHVYLVMELMDASLCQVIQMD-LDHERLSYLLYQLLCGIKHLHS  166

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v +dc+lkildFGlar+a  + +  +t+yv+tr+YraPe++l  +

Q: 167   AGIIHRDLKPSNIVVRSDCTLKILDFGLARTAGGSFM--MTPYVVTRYYRAPEVILG-MG  223

         *********************************9976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y++ vDiWsvGCI++E+++g++lfpg+d+idq++ki+e+lgtpse+f++k++  ++rny+

Q: 224   YQEVVDIWSVGCIFGEMIRGQVLFPGNDHIDQWNKITEQLGTPSEDFINKLQP-TVRNYV  282

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk.............aseealdLleklLvldpdkRisveeaLehp  287

          ++p ++ +++++lfp+              s++a+dLl k+Lv+dp  Ri+v++aL+hp

Q: 283   LNRPFQRGHPIHRLFPDslfpadsesngrlRSSQARDLLAKMLVVDPIGRITVDDALQHP  342

         ************************************************************

S: 288   Yl  289

Y+

Q: 343   YI  344

*7

Domain Sequence
(FASTA)

YQSLKPIGSG AQGMVCAAHD TVLGQHVAIK KLSRPFQNPT HAKRAYRELV LMRAVNHKNI 60

IGLLNVFSPQ SSYEDFSHVY LVMELMDASL CQVIQMDLDH ERLSYLLYQL LCGIKHLHSA 120

GIIHRDLKPS NIVVRSDCTL KILDFGLART AGGSFMMTPY VVTRYYRAPE VILGMGYQEV 180

VDIWSVGCIF GEMIRGQVLF PGNDHIDQWN KITEQLGTPS EDFINKLQPT VRNYVLNRPF 240

QRGHPIHRLF PDSLFPADSE SNGRLRSSQA RDLLAKMLVV DPIGRITVDD ALQHPYI 297

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013