EKS-CII-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	311.2	4.6E-93	33	294	262

Status

Unreviewed

Ensembl Protein

ENSCINP00000019622

UniProt Accession

F6WV80;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000009652	ENSCINP00000019622	ENSCINT00000019622

Organism

Ciona intestinalis

Functional Description

Protein Length

1197

Protein Sequence
(FASTA)

MSFFKKILKI GQENNKPKVY EHIKRGENPE SQWEKVCELG DGAFGVVYKA RHKVDGRLAA 60

AKIIECRAEE DLEDFAVEIN ILASCNHPNI VKLLDAFYFE MNLWVLIEFC DGGALDSIIL 120

ELERGLEERQ IQVVCKKTCH ALQYLHQNKI IHRDLKAGNV LLTMDGEVKL ADFGVSALNT 180

RTMQKRDTFI GTPYWMAPEV VMCETFKDTP YNYSADIWSL GITLIELAQT EPPNHDLNPV 240

RVLLRVAKSE PPTLDIPSRW LVMSKEFSSF ISRCLVKDPT KRASLSELLN HPFLTNISSP 300

QPLVKLIAEA KADVTEEVEE PVRIFLFILN LLISNVFWFY ENLNLVKTTA SKSLNMSYWA 360

KMYTLGCHQN CKKDVFIINL GSCLVELKVT YLLKDEGNQT PEINRRSAAI SEASLTQRNN 420

SDASGASLNN HETDSIGSSG LSPFHDVDVA SIKSSDSKDT KSLDAQSSPA STKVSDIIPV 480

SKVNEDSSSS EGSTSEKIDS DEKLRNNSPT QASVGDKPEN VPIMTSQEEN LNNEKAEKLS 540

IGETAEKISV GDNVSEDGDQ LTPLRSSSSS AHVSSTNTQQ SSVSSVTNHD FVNQTKSTAI 600

DTTDVDKVIE SKPISDGLST GAVPRGTSFH SLNKIPAELA AYNKIETESK SREDEALAID 660

MLDKVLSSPL ASDGTKNPTP PQQTESSDSA VESLPDVLPS VEVQIDNDRT TRASTTSDEN 720

TSLHSLAATS DASSTDNTTA TNDKQRIKNQ HKTLKKTRRY IIDGVEVTST STKVIDDWDF 780

ENQKEKRVLR RQELQELRKL QRDEQRQIAA LNTKLSSQLE QMTIKFEQEM ANLKRRYVME 840

MDQMERGQKS QIEKLEQNQE HNRKELISTL KKEQDKERKQ FFESLKMEQK ELKFELERLP 900

KQQRKEMSRR RKEELEVKHQ NEEKLFFEGQ TEKLRMGVRQ MTETHKRDIA ATERVCLLKK 960

QDLQRSRECD IWKIEESHLH ERYQTTKQQI KDQYHLQRHQ LVIRHDKEQE QMHRHNKRSR 1020

EELISHQQQE KVRLPKIQRS EGKARMSMFK RSLRIQSTYE GKAAVNEREK IKQFTITETK 1080

RMKAEKLKQH LKHETQLKEL DARSEANMRE LMQLQNEKRR MVVDHEELKI KELDEGFQEE 1140

MKMWKEQLKP RKKRLEDTFT QQLEEQKKFF NGPEPNSSNH EVKQRPPNDG ATTFYKL 1197

Nucleotide Sequence
(FASTA)

ATGTCATTCT TCAAGAAAAT TCTTAAAATT GGGCAAGAAA ACAACAAGCC CAAAGTTTAT 60

GAACACATAA AACGTGGTGA GAATCCAGAG TCGCAGTGGG AAAAAGTCTG TGAACTTGGA 120

GATGGAGCAT TTGGAGTCGT TTATAAGGCT CGTCACAAAG TAGATGGTCG ACTTGCGGCA 180

GCAAAGATCA TCGAATGTCG AGCGGAGGAA GATCTTGAAG ATTTTGCCGT GGAAATCAAC 240

ATCCTTGCTT CGTGTAATCA TCCAAATATT GTGAAACTCC TTGATGCATT TTACTTTGAG 300

ATGAATCTAT GGGTGTTGAT TGAGTTTTGT GATGGTGGAG CGTTGGATTC AATCATACTA 360

GAACTTGAGC GTGGGTTGGA GGAGAGACAG ATACAAGTTG TCTGTAAAAA AACTTGCCAT 420

GCCCTGCAGT ATCTTCATCA GAACAAAATA ATTCACAGGG ATCTCAAAGC AGGGAATGTA 480

CTTCTTACCA TGGATGGTGA AGTTAAACTT GCTGATTTTG GAGTATCAGC TCTCAACACA 540

AGGACGATGC AGAAACGTGA TACTTTCATT GGCACACCAT ATTGGATGGC ACCTGAAGTT 600

GTTATGTGCG AAACATTCAA GGATACCCCA TACAATTACT CAGCTGATAT TTGGTCACTT 660

GGAATAACTC TGATTGAGCT GGCGCAGACG GAACCACCCA ACCATGACCT CAACCCTGTT 720

CGTGTTTTAC TACGGGTCGC CAAGTCGGAA CCTCCAACAT TGGATATACC AAGCAGATGG 780

TTGGTAATGT CAAAGGAGTT TTCAAGCTTC ATATCTCGAT GTTTGGTAAA AGATCCAACG 840

AAAAGAGCGT CGCTATCCGA GTTGCTTAAC CATCCTTTCC TCACCAACAT CTCGTCACCA 900

CAACCTCTTG TGAAGTTGAT CGCTGAAGCA AAAGCTGATG TCACAGAAGA AGTTGAAGAA 960

CCTGTGAGAA TTTTTTTGTT TATTTTAAAT CTGTTGATTT CCAATGTGTT CTGGTTTTAT 1020

GAAAATTTGA ACCTAGTTAA GACTACTGCT TCTAAATCTC TTAATATGTC CTATTGGGCC 1080

AAAATGTACA CATTGGGTTG CCATCAAAAT TGTAAAAAAG ATGTTTTTAT AATCAATCTT 1140

GGGTCTTGTT TAGTTGAATT GAAAGTTACA TATTTATTAA AGGATGAAGG AAATCAAACT 1200

CCCGAGATCA ATCGAAGATC TGCTGCCATT AGTGAGGCAA GTTTAACACA GAGGAACAAT 1260

TCTGATGCAT CTGGTGCATC TCTCAATAAT CATGAGACAG ATTCCATTGG TTCATCTGGA 1320

TTATCACCCT TTCATGATGT AGACGTGGCA TCCATCAAAT CTAGTGACAG CAAAGATACA 1380

AAGTCCTTGG ATGCTCAATC AAGTCCTGCA TCTACTAAAG TGAGTGATAT CATCCCAGTC 1440

TCAAAGGTAA ATGAGGACTC GTCCTCCAGT GAAGGGAGCA CAAGCGAAAA AATCGATTCT 1500

GATGAAAAAT TAAGAAATAA TTCCCCAACC CAGGCTTCTG TTGGTGATAA ACCTGAGAAT 1560

GTCCCAATTA TGACATCACA GGAAGAAAAT CTTAATAATG AGAAAGCTGA AAAACTTTCA 1620

ATTGGTGAAA CAGCAGAGAA GATTTCTGTT GGTGATAACG TCAGTGAGGA TGGGGATCAG 1680

CTAACTCCTC TTCGCTCCTC TTCATCCTCA GCGCATGTCA GTTCCACTAA CACGCAACAA 1740

TCTTCTGTTT CCTCAGTTAC TAACCATGAT TTTGTTAACC AAACTAAATC AACAGCAATC 1800

GACACCACAG ATGTAGATAA GGTTATCGAG AGTAAACCTA TCAGTGATGG TTTAAGCACA 1860

GGTGCAGTAC CCAGAGGTAC ATCTTTCCAT TCGCTTAATA AAATACCAGC TGAGCTGGCT 1920

GCTTATAACA AAATAGAGAC TGAATCAAAA AGTAGAGAAG ATGAAGCTTT AGCGATAGAT 1980

ATGCTTGATA AGGTGCTCAG CTCTCCTCTT GCATCTGATG GCACAAAAAA TCCGACTCCT 2040

CCTCAACAAA CGGAGTCTTC TGACTCCGCT GTTGAATCTC TTCCTGATGT TTTACCATCG 2100

GTTGAGGTTC AGATTGATAA CGATCGAACA ACAAGAGCAT CCACCACCAG TGATGAGAAC 2160

ACATCACTTC ATTCATTAGC TGCTACATCA GATGCATCAT CCACTGACAA CACAACAGCT 2220

ACAAACGACA AACAGAGAAT AAAGAACCAG CACAAAACAT TGAAGAAGAC TCGTCGTTAC 2280

ATCATTGATG GTGTGGAGGT CACTTCAACA TCAACAAAAG TTATCGATGA CTGGGATTTT 2340

GAAAACCAAA AGGAAAAGCG TGTTTTGCGG CGACAAGAAT TACAGGAGCT TCGTAAACTA 2400

CAACGAGATG AGCAACGTCA GATTGCTGCT CTTAACACTA AGTTGTCATC TCAACTTGAA 2460

CAAATGACAA TCAAGTTTGA ACAAGAAATG GCTAACTTGA AGCGTCGATA TGTGATGGAG 2520

ATGGACCAGA TGGAAAGAGG TCAAAAATCT CAAATCGAAA AATTGGAACA AAATCAGGAA 2580

CATAATCGGA AGGAATTGAT CAGCACACTG AAGAAGGAAC AAGATAAAGA AAGAAAGCAA 2640

TTCTTTGAGT CACTGAAGAT GGAACAGAAG GAGCTTAAGT TTGAGTTGGA ACGACTTCCC 2700

AAACAACAAC GTAAAGAGAT GAGCAGAAGG AGGAAAGAGG AGCTGGAGGT CAAACATCAG 2760

AACGAGGAGA AGTTATTTTT TGAAGGCCAA ACAGAGAAAC TTCGAATGGG TGTTCGTCAA 2820

ATGACGGAAA CTCACAAACG CGACATCGCA GCCACTGAGA GAGTTTGTTT GCTTAAAAAA 2880

CAAGATTTAC AACGATCTCG TGAATGCGAT ATTTGGAAGA TAGAAGAAAG TCACCTTCAT 2940

GAAAGATATC AAACAACTAA ACAACAAATT AAAGATCAAT ATCATTTACA ACGTCATCAA 3000

CTTGTCATAC GACATGATAA GGAACAAGAA CAGATGCATC GTCATAACAA GCGCTCGAGG 3060

GAGGAACTTA TTTCTCATCA ACAACAAGAA AAAGTTCGAC TTCCCAAGAT ACAACGTAGT 3120

GAAGGAAAAG CAAGAATGTC GATGTTTAAA AGAAGTTTAA GAATCCAAAG CACTTATGAA 3180

GGAAAAGCTG CAGTTAATGA AAGGGAGAAA ATCAAACAGT TCACCATAAC TGAAACAAAA 3240

CGAATGAAAG CCGAGAAGTT GAAGCAGCAT CTGAAGCATG AGACTCAATT AAAGGAGCTC 3300

GATGCAAGGT CTGAGGCAAA CATGAGGGAG CTGATGCAGC TGCAGAATGA GAAGAGGAGG 3360

ATGGTGGTGG ATCATGAGGA GCTGAAGATC AAGGAGCTTG ATGAGGGATT CCAAGAAGAG 3420

ATGAAGATGT GGAAGGAGCA GCTTAAACCA AGGAAGAAGA GATTGGAAGA CACTTTTACG 3480

CAACAGTTAG AAGAACAGAA GAAGTTTTTC AACGGGCCGG AACCAAACTC ATCCAACCAT 3540

GAAGTGAAAC AAAGACCTCC AAATGATGGC GCCACCACTT TTTATAAATT ATAA 3594

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e + e+g+Ga+g vy+ar+k  g+l+a k+i+++++e+le+++ ei++l +++hpniv+

Q: 33    WEKVCELGDGAFGVVYKARHKVDGRLAAAKIIECRAEEDLEDFAVEINILASCNHPNIVK  92

         678899******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f+ e +lw+++e++ gG+l++++  el+++l+E+qi+++++++++aL+ylH++k+i

Q: 93    LLDAFYFEMNLWVLIEFCDGGALDSIIL-ELERGLEERQIQVVCKKTCHALQYLHQNKII  151

         ***************************9.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+n+Llt++geVkL+dfgv+a  ++t++kr+t++gtpywmAPEv+ +e   ++ Y

Q: 152   HRDLKAGNVLLTMDGEVKLADFGVSALNTRTMQKRDTFIGTPYWMAPEVVMCEtfkDTPY  211

         *****************************************************999999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkf...skefkefv  234

         ++ aDiwslGIt+iela+ epP +dl+p+++ll+++k+epp+l  ++++   skef++f+

Q: 212   NYSADIWSLGITLIELAQTEPPNHDLNPVRVLLRVAKSEPPTLDIPSRWlvmSKEFSSFI  271

         *******************************************999884444********

S: 235   ekclqknpekRpsasellkhkFl  257

         ++cl k+p kR+s sell+h+Fl

Q: 272   SRCLVKDPTKRASLSELLNHPFL  294

         **********************7

Domain Sequence
(FASTA)

WEKVCELGDG AFGVVYKARH KVDGRLAAAK IIECRAEEDL EDFAVEINIL ASCNHPNIVK 60

LLDAFYFEMN LWVLIEFCDG GALDSIILEL ERGLEERQIQ VVCKKTCHAL QYLHQNKIIH 120

RDLKAGNVLL TMDGEVKLAD FGVSALNTRT MQKRDTFIGT PYWMAPEVVM CETFKDTPYN 180

YSADIWSLGI TLIELAQTEP PNHDLNPVRV LLRVAKSEPP TLDIPSRWLV MSKEFSSFIS 240

RCLVKDPTKR ASLSELLNHP FL 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013