EKS-CII-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	416.3	5.3E-125	187	474	288

Status

Unreviewed

Ensembl Protein

ENSCINP00000005916

UniProt Accession

F6SCX5;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr-ic

Gene Synonyms/Alias

tgfbr-ic;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000014075	ENSCINP00000005916	ENSCINT00000005916

Organism

Ciona intestinalis

Functional Description

Protein Length

486

Protein Sequence
(FASTA)

SALTCYCGGS RENPYCERNV FNCTVPEGVC YAMTEVLPIS KNILTQRGCF RKNRLVPYNR 60

PFVCEPVNKS NHQVICCKTD FCNHPEAMEA PTLPTTTASI QTNQDQLSTT LIVLLSVGGF 120

LLMAMLVLVA VFYKKQHSKR NDPLVESQNS SLPDTNMQDL LDDKDFSTTG SGSGLPLLVH 180

RTIARQIQLQ EVIGKGRYGE VFRGKWRGED VAVKKFVTRD ERSWAREAEI YQTIMLRHEN 240

ILGFIAADNK DVGTWTELWL ISEYHENGSL FDYLGETRVD VGAMLKLCSS IASGLAHLHN 300

EIVGTLGKPP IAHCDLKSKN ILVKKNGECA IADLGLAVRH DSSTDTIDIP PNNRVGTKRY 360

MAPEILDDTL NMLHFDSFKR ADIYSLGLVL WEIGRRCSIG GQNLDYQLPY YNMVPDDPTI 420

EQMRVVVCEK MFRPQKEATW HKYDTMERMW KLMNECWYES GCARLTALRV KKTIAKIEDE 480

EGVKNI 486

Nucleotide Sequence
(FASTA)

TCAGCACTAA CATGTTACTG TGGTGGCTCA CGAGAAAACC CATATTGTGA AAGAAATGTA 60

TTTAACTGCA CTGTGCCAGA AGGTGTTTGT TATGCCATGA CGGAAGTTCT ACCTATTTCA 120

AAAAATATTT TGACTCAAAG AGGATGTTTT AGAAAAAACA GATTGGTGCC ATACAACCGA 180

CCATTTGTAT GTGAACCAGT CAATAAATCC AACCATCAAG TCATATGTTG CAAAACAGAC 240

TTCTGTAACC ATCCTGAAGC AATGGAAGCA CCAACATTGC CCACAACAAC TGCCAGCATT 300

CAAACTAATC AAGATCAACT GTCAACAACA TTAATCGTTT TATTATCAGT TGGCGGGTTC 360

TTGTTGATGG CAATGCTTGT TCTTGTTGCG GTTTTCTATA AAAAGCAACA CAGCAAGAGA 420

AATGACCCAT TGGTGGAAAG CCAGAATTCA AGCCTACCAG ACACTAACAT GCAAGATCTC 480

TTGGACGACA AGGACTTCTC TACTACTGGT TCAGGTTCAG GATTGCCATT ACTTGTCCAT 540

CGAACTATTG CTCGACAAAT TCAACTACAA GAAGTTATTG GAAAGGGAAG GTATGGTGAG 600

GTGTTTCGTG GTAAATGGAG GGGTGAAGAC GTCGCGGTAA AGAAGTTTGT GACTCGCGAT 660

GAGAGATCCT GGGCAAGGGA GGCAGAGATT TATCAAACCA TCATGTTACG ACATGAGAAT 720

ATACTCGGAT TCATTGCTGC AGATAACAAA GATGTTGGGA CATGGACTGA ACTATGGTTG 780

ATATCGGAAT ACCACGAGAA TGGATCTTTG TTCGATTATC TTGGTGAAAC ACGTGTGGAT 840

GTTGGTGCCA TGCTTAAGTT ATGCAGCTCC ATTGCTAGTG GGTTGGCTCA TTTGCATAAT 900

GAGATTGTTG GTACTTTAGG AAAACCCCCA ATAGCTCATT GTGATTTAAA GTCAAAGAAT 960

ATTTTGGTGA AAAAAAATGG TGAATGTGCA ATTGCTGATC TTGGGTTGGC GGTCAGACAT 1020

GATTCAAGCA CCGACACTAT TGACATTCCT CCTAATAACA GGGTGGGAAC CAAAAGATAC 1080

ATGGCACCTG AGATACTGGA TGACACATTA AACATGTTAC ATTTTGACTC TTTCAAACGT 1140

GCGGATATAT ATTCACTGGG ACTTGTGCTG TGGGAGATTG GTCGCAGATG TAGCATTGGA 1200

GGTCAGAATC TTGATTACCA ACTTCCATAT TACAACATGG TACCTGATGA TCCAACAATT 1260

GAACAAATGA GAGTCGTTGT GTGTGAGAAG ATGTTTAGAC CACAGAAGGA AGCAACATGG 1320

CATAAATATG ATACCATGGA GCGAATGTGG AAACTGATGA ATGAATGTTG GTACGAGAGC 1380

GGATGCGCAC GTTTAACTGC ACTGCGAGTA AAGAAGACGA TCGCGAAGAT AGAAGATGAG 1440

GAAGGAGTGA AGAATATTTG A 1461

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e+igkGrygeV+++k+rge+vAvK f t+de+sw rE+eiyqt++lrhenil+fia

Q: 187   IQLQEVIGKGRYGEVFRGKWRGEDVAVKKFVTRDERSWAREAEIYQTIMLRHENILGFIA  246

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+ +++tel+l++eyhe+gsL+dyL ++ +dv  +l+l++s+asGlahLH+eivgt

Q: 247   ADNKDVGTWTELWLISEYHENGSLFDYLGETRVDVGAMLKLCSSIASGLAHLHNEIVGTL  306

         ***********************************************************9

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaH DlkskNilvkk++ c+iaDlGLa++++++++++d+  n++vGtkRYmaPE

Q: 307   G--KPPIAHCDLKSKNILVKKNGECAIADLGLAVRHDSSTDTIDIPPNNRVGTKRYMAPE  364

         9..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l+++ln+ +f++fkraD+YslgLvlWE+ +Rc+  +++  +y+lp++++v+ dP++e+m

Q: 365   ILDDTLNMLHFDSFKRADIYSLGLVLWEIGRRCSI-GGQNLDYQLPYYNMVPDDPTIEQM  423

         ***********************************.999*********************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         + vv+ek  rP+ + +w+k ++++ + kl++ecW++ + aRltalrvkk++

Q: 424   RVVVCEKMFRPQKEATWHKYDTMERMWKLMNECWYESGCARLTALRVKKTI  474

         ************************************************986

Domain Sequence
(FASTA)

IQLQEVIGKG RYGEVFRGKW RGEDVAVKKF VTRDERSWAR EAEIYQTIML RHENILGFIA 60

ADNKDVGTWT ELWLISEYHE NGSLFDYLGE TRVDVGAMLK LCSSIASGLA HLHNEIVGTL 120

GKPPIAHCDL KSKNILVKKN GECAIADLGL AVRHDSSTDT IDIPPNNRVG TKRYMAPEIL 180

DDTLNMLHFD SFKRADIYSL GLVLWEIGRR CSIGGQNLDY QLPYYNMVPD DPTIEQMRVV 240

VCEKMFRPQK EATWHKYDTM ERMWKLMNEC WYESGCARLT ALRVKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013