EKS-CII-00206

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00206

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	410.3	2.3E-123	197	451	255

Status

Unreviewed

Ensembl Protein

ENSCINP00000008019

UniProt Accession

F6TXB9;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100177580

Gene Synonyms/Alias

LOC100177580;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000016554	ENSCINP00000008019	ENSCINT00000008019

Organism

Ciona intestinalis

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MPSRPSLQGQ VRYVALYDYD ARTADDLSFK KGEQLFILNS TQSEGDWWEA RSLVTQHTGY 60

IPSNYVAPAN SVQCEEWFFG KIGRKDSERL LLNQENLRGT FLIRESETAP GTFSLSILDE 120

DQAKGLNVKH YRIRKLDSGG FYITARAQFE TLKNLVDHYQ NVTDGLCCRL LDPCPLLEKP 180

QTITIARDVW EIPRESLKLE KKLGAGMFGE VWKGLWNGTT EVAIKTLKTG TMSPEAFLAE 240

AKIMKMLRHE KLVSLYAVVS KEPIYIVTEF MCHGSLLDYL KEGPGHKSNL VDQIDMAAQI 300

AAGMAYIERM NYIHRDVRAA NILVGKNQVC KIADFGLARL IVDNEYSARQ GAKFPIKWTA 360

PEAAMYGKFT IKSDVWSFGI LLTEIVTKGR IPYPGMMNRE VLEQVERGYR MPKPTLGPND 420

PPCPDSLYDL MIQCWNKEVL YRPTFEYIQG FLEDYFTATE PNYREASDF 469

Nucleotide Sequence
(FASTA)

ATGCCGAGTC GGCCTTCATT GCAAGGGCAA GTAAGATACG TTGCTTTATA TGATTATGAT 60

GCAAGAACTG CAGATGATTT GTCTTTTAAA AAGGGAGAGC AGTTATTCAT TCTGAATAGC 120

ACGCAAAGTG AAGGGGACTG GTGGGAAGCA AGGTCATTGG TTACCCAACA TACTGGGTAT 180

ATACCAAGCA ATTATGTTGC TCCTGCAAAT TCTGTTCAAT GCGAAGAGTG GTTCTTTGGT 240

AAAATTGGCC GAAAAGATTC TGAGCGATTA TTATTGAACC AGGAAAATCT TAGAGGTACT 300

TTCCTTATTA GAGAAAGTGA AACTGCACCA GGAACATTTT CTCTTTCAAT TCTGGACGAG 360

GATCAAGCCA AAGGATTAAA TGTGAAGCAT TATCGAATTA GGAAACTGGA TAGTGGAGGA 420

TTTTATATAA CTGCAAGGGC TCAGTTTGAA ACACTAAAGA ATCTTGTAGA CCACTATCAG 480

AATGTTACGG ATGGTTTATG TTGTCGCCTA CTTGATCCTT GTCCTCTTTT GGAAAAACCC 540

CAGACAATAA CAATTGCGAG GGATGTGTGG GAAATACCAC GAGAATCCCT TAAATTAGAA 600

AAAAAATTGG GTGCTGGTAT GTTTGGTGAG GTTTGGAAAG GACTTTGGAA TGGCACAACG 660

GAAGTTGCAA TAAAGACATT GAAAACTGGT ACCATGTCTC CAGAAGCATT CCTTGCTGAA 720

GCAAAGATAA TGAAGATGTT ACGTCATGAA AAGCTAGTCA GTCTTTATGC TGTGGTTTCC 780

AAAGAACCAA TTTACATTGT TACTGAATTT ATGTGTCACG GGAGTTTACT GGATTATTTG 840

AAGGAAGGTC CAGGTCACAA ATCCAACTTA GTCGACCAAA TTGATATGGC AGCCCAGATT 900

GCTGCTGGCA TGGCTTACAT AGAAAGAATG AATTACATTC ACCGCGATGT TCGTGCTGCC 960

AATATTCTTG TTGGGAAAAA TCAAGTTTGT AAAATTGCTG ACTTTGGGTT GGCCCGACTT 1020

ATTGTGGATA ATGAATACAG TGCACGACAA GGAGCCAAAT TTCCAATAAA ATGGACAGCA 1080

CCCGAAGCTG CAATGTATGG AAAGTTTACC ATTAAATCGG ATGTTTGGAG TTTTGGTATT 1140

CTACTAACAG AGATTGTGAC CAAAGGAAGA ATCCCCTACC CAGGTATGAT GAATAGAGAA 1200

GTACTTGAGC AAGTGGAAAG AGGTTACAGG ATGCCCAAAC CAACCCTTGG CCCAAACGAT 1260

CCACCGTGTC CCGATTCATT ATATGACCTT ATGATACAGT GTTGGAACAA GGAAGTTTTA 1320

TATCGACCCA CATTTGAATA CATACAAGGG TTCCTAGAAG ATTATTTTAC TGCCACAGAA 1380

CCGAATTACA GGGAGGCTAG TGATTTTTAA 1410

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl+kklG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+ea+i+k lrheklv+ly

Q: 197   LKLEKKLGAGMFGEVWKGLWNGTTEVAIKTLKTGTMSPEAFLAEAKIMKMLRHEKLVSLY  256

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvs+ ePiyivte+m +Gslld+lke  g+k +l +++d+aaq+a+Gmay+e++n+ihr

Q: 257   AVVSK-EPIYIVTEFMCHGSLLDYLKEGPGHKSNLVDQIDMAAQIAAGMAYIERMNYIHR  315

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         d++a+n+lvg+++v+k+adfGlarli d+ey+a++gak+PikWtaPea+ +gkftiksdv

Q: 316   DVRAANILVGKNQVCKIADFGLARLIVDNEYSARQGAKFPIKWTAPEAAMYGKFTIKSDV  375

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpee......cpeelyelllecw  234

         WsfGillteivtkG++PypGm n+evleqvergyr+p+p+       cp++ly+l+++cw

Q: 376   WSFGILLTEIVTKGRIPYPGMMNREVLEQVERGYRMPKPTLgpndppCPDSLYDLMIQCW  435

         **************************************9743334449************

S: 235   kkdpeerPtfetlqev  250

         +k+   rPtfe++q +

Q: 436   NKEVLYRPTFEYIQGF  451

         ************9976

Domain Sequence
(FASTA)

LKLEKKLGAG MFGEVWKGLW NGTTEVAIKT LKTGTMSPEA FLAEAKIMKM LRHEKLVSLY 60

AVVSKEPIYI VTEFMCHGSL LDYLKEGPGH KSNLVDQIDM AAQIAAGMAY IERMNYIHRD 120

VRAANILVGK NQVCKIADFG LARLIVDNEY SARQGAKFPI KWTAPEAAMY GKFTIKSDVW 180

SFGILLTEIV TKGRIPYPGM MNREVLEQVE RGYRMPKPTL GPNDPPCPDS LYDLMIQCWN 240

KEVLYRPTFE YIQGF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013