EKS-CII-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	418.6	7.6E-126	114	379	266

Status

Unreviewed

Ensembl Protein

ENSCINP00000031277

UniProt Accession

H2XNP4;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

LOC100178831

Gene Synonyms/Alias

LOC100178831;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000018425	ENSCINP00000031277	ENSCINT00000032588

Organism

Ciona intestinalis

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSFRKKNSCP VPRDLLPGKY QASILPTSLA AKGVWSQPIS FIVEDVNTTS LSSMVAIIVV 60

GIIVILIVIL IVYLRKRQIH NSKKSQTYVS VNPEYSSIGV YEPDEYEIPE ENVELMDEIG 120

HGHFGKVYEG LAKQVVKGQP KTKVAVKTLH GNESISKRME FLKEASVMKA FNSHHVVRLL 180

GVVSMSKRPM VIMEFMAKGD LKTYLRSTRP DAEIRKGDPP SLQQKLQMCG EIADGMSYLS 240

ETKYVHRDLA ARNCLVHEDL TVKIGDFGLT RDVYETDYYR IDSRGILPVR WMAPESLKDG 300

VFDSRSDVWS FGIVLWEIAT LAEQPYQGQQ HDQVTRFVID GGYMEQPKEC PSKLYDMMLM 360

CWHYSPSMRP TFLEIVASLS PDLSDRFKQD SFFHETKQAE EISNDGDGFV ASGSSERVRF 420

LPKQVAADVH EDESKQSDDE SSAYCRLNGL HQNDPSADYD DKDGSIHLTL YSRNNSTIC 479

Nucleotide Sequence
(FASTA)

ATGTCATTCC GGAAGAAAAA TTCTTGCCCG GTACCTCGGG ACTTGTTACC GGGCAAATAC 60

CAAGCCAGTA TTCTGCCAAC TTCACTCGCA GCTAAAGGTG TTTGGTCACA ACCCATAAGT 120

TTTATTGTTG AAGACGTGAA TACGACGTCT TTATCATCAA TGGTGGCAAT TATAGTTGTC 180

GGTATCATCG TGATACTGAT CGTCATATTG ATTGTCTACT TGAGAAAAAG GCAAATTCAT 240

AACTCAAAGA AATCTCAGAC CTATGTTTCT GTGAATCCGG AATATTCCAG TATCGGCGTG 300

TATGAACCGG ACGAATACGA GATTCCGGAA GAAAATGTTG AATTGATGGA TGAAATTGGG 360

CACGGACACT TTGGCAAGGT ATATGAAGGT TTGGCAAAGC AGGTGGTGAA GGGACAACCG 420

AAAACAAAAG TTGCTGTTAA GACACTTCAT GGAAATGAAA GTATTTCAAA AAGAATGGAA 480

TTTTTGAAAG AAGCGAGCGT TATGAAAGCA TTCAACTCCC ACCATGTTGT TCGTTTACTT 540

GGGGTGGTAT CCATGTCAAA ACGGCCCATG GTTATCATGG AGTTCATGGC AAAAGGAGAT 600

CTCAAAACTT ACCTGCGTTC CACCAGACCA GATGCTGAGA TTCGCAAAGG TGATCCCCCT 660

AGTCTACAAC AGAAGCTACA AATGTGTGGT GAAATAGCCG ACGGGATGAG CTATCTTTCA 720

GAGACAAAAT ACGTCCATAG AGATCTCGCT GCTCGTAATT GTTTGGTGCA TGAAGACCTC 780

ACAGTTAAGA TCGGTGACTT TGGATTGACG CGTGATGTTT ACGAGACAGA TTATTACCGC 840

ATTGATAGCA GAGGAATTCT CCCTGTACGT TGGATGGCAC CTGAGTCGTT AAAAGATGGC 900

GTGTTTGACT CTCGTAGCGA TGTTTGGTCG TTTGGTATCG TGTTATGGGA GATTGCTACT 960

TTAGCAGAAC AACCATATCA AGGCCAACAG CATGACCAAG TCACAAGGTT TGTCATCGAT 1020

GGTGGATACA TGGAACAGCC AAAGGAATGT CCTTCGAAGC TATACGACAT GATGCTTATG 1080

TGTTGGCACT ATAGCCCCAG CATGCGACCA ACGTTTTTAG AGATCGTGGC TTCGTTATCT 1140

CCCGATTTAT CTGATCGTTT CAAGCAAGAT TCTTTCTTTC ACGAAACAAA ACAAGCGGAA 1200

GAAATTTCCA ACGACGGAGA CGGCTTCGTG GCCTCGGGTT CGAGTGAGAG GGTTCGGTTT 1260

CTACCGAAGC AAGTTGCAGC TGATGTCCAT GAAGACGAGA GTAAGCAGAG CGACGACGAA 1320

AGTTCGGCTT ACTGTAGGCT TAATGGTCTC CATCAAAACG ACCCTTCAGC CGATTACGAC 1380

GATAAGGACG GTTCGATCCA TTTAACGCTT TATTCGCGGA ACAATTCAAC AATCTGCTGA 1440

Domain Profile

S: 2     vllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefkt  61

          l+ e+G+G fG+vyeG+ak+vvkg+ +t+va+kt   + s  +r+eflkeasvmk+f++

Q: 114   ELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFLKEASVMKAFNS  173

         57899*******************************************************

S: 62    hhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaaei  121

         hhvvrllGvvs ++  +v+me+m+kGdlk ylrs rp++e  ++  pp+l++  qm++ei

Q: 174   HHVVRLLGVVSMSKRPMVIMEFMAKGDLKTYLRSTRPDAEIRKG-DPPSLQQKLQMCGEI  232

         **************************************997665.6788***********

S: 122   adGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrwm  181

         adGm+yl+  k+vhrdlaarnc+v edltvkiGdfG+trd+yetdyyr  ++g+lpvrwm

Q: 233   ADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDVYETDYYRIDSRGILPVRWM  292

         ************************************************************

S: 182   speslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencpe  241

         +peslkdGvf+s+sdvwsfG+vlwei+tlaeqpyqG   +qv +fv+dgg++e+p+ cp+

Q: 293   APESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHDQVTRFVIDGGYMEQPKECPS  352

         ************************************************************

S: 242   lltelmrlcwqynpklrpsfleivell  268

         +l+++m +cw+y+p++rp+fleiv++l

Q: 353   KLYDMMLMCWHYSPSMRPTFLEIVASL  379

         ************************875

Domain Sequence
(FASTA)

ELMDEIGHGH FGKVYEGLAK QVVKGQPKTK VAVKTLHGNE SISKRMEFLK EASVMKAFNS 60

HHVVRLLGVV SMSKRPMVIM EFMAKGDLKT YLRSTRPDAE IRKGDPPSLQ QKLQMCGEIA 120

DGMSYLSETK YVHRDLAARN CLVHEDLTVK IGDFGLTRDV YETDYYRIDS RGILPVRWMA 180

PESLKDGVFD SRSDVWSFGI VLWEIATLAE QPYQGQQHDQ VTRFVIDGGY MEQPKECPSK 240

LYDMMLMCWH YSPSMRPTFL EIVASL 266

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013