EKS-CII-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	320.7	6.0E-96	432	680	249

Status

Unreviewed

Ensembl Protein

ENSCINP00000033642

UniProt Accession

H2XVF8;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000020161	ENSCINP00000033642	ENSCINT00000031612

Organism

Ciona intestinalis

Functional Description

Protein Length

699

Protein Sequence
(FASTA)

MFKGKNKRKP DISGPSNFEH RVHTGFNEDE GKFIGLPIQW QSIIPDIKNR PKPFIDARHI 60

TPVPVEKVNK IITGKSKTKG PLSNLTAISV TRSNSLRKES PPEIKKLQSR RRHRNNSSHR 120

HEGGHQYDTV FDEEKRSSNS RHSSHRKHSE RTNSGRTHSR DRYEQPHDHH HRSSRESRSQ 180

RDIYDRSVEK VYSSNHRDRN DRSHRTSDTS VRETSESGPD SRSQSKRTTS HSRRPPDSHD 240

VPDHRQATMP LPSDSREKSR KNKDYYTYSS TVDVRPQNEN TVAEHTYQNI SNGHRSSEQT 300

NTNEKSFRRG QGNVLLVKFD LHPLNITKLI SNIPPQRKMT ASHVQRTGDY ILPNKSPSPN 360

KMNSPVHIRG YNDRTYTRKP EPLSPGVSVA PPAAQKALGT KRDSHAVTND QFRAALQMVV 420

CPGDPRESLE NFLKIGEGST GVVCIANEKG TGRHVAVKKM NVRKQQRREL LFNEVVIMRD 480

YHHENIVDMY SSFLVDDELW VVMEYMEGGA LTDIVTRTRL NEQQIATVCV SVLNALAYLH 540

AQGVIHRDIK SDSILLTKDL TVKLSDFGFC AQISSDVPKR KSLVGTPYWM APEVVSRTPY 600

GPEVDIWSLG IMVMEMVDKE PPYFDEAPLQ AMRKIRDMPP PKLKNAHKAS PLLKGFLDQV 660

LVRDPSTRST ALELLQHPFL RKSSSHKSIG PISLPGITR 699

Nucleotide Sequence
(FASTA)

ATGTTCAAGG GTAAAAATAA GAGAAAACCG GATATATCCG GTCCGTCAAA TTTCGAGCAT 60

CGAGTCCACA CTGGTTTCAA TGAAGATGAG GGAAAGTTTA TCGGGTTGCC GATCCAATGG 120

CAGAGTATTA TCCCCGATAT AAAGAACCGG CCGAAGCCAT TTATTGACGC AAGGCATATC 180

ACCCCTGTGC CTGTGGAAAA GGTGAATAAA ATCATCACTG GGAAAAGTAA AACCAAGGGA 240

CCTTTATCCA ACCTCACAGC TATATCTGTA ACTCGTTCCA ACTCACTCCG CAAAGAAAGT 300

CCTCCTGAAA TTAAAAAACT TCAGAGCAGA AGAAGACATC GCAACAACAG CAGCCATAGA 360

CATGAAGGTG GTCACCAATA TGACACAGTG TTTGATGAAG AAAAGCGATC TTCCAACAGC 420

CGGCATTCCT CGCATAGAAA ACACAGTGAA AGGACAAACA GCGGTCGTAC ACACTCACGT 480

GATCGATACG AGCAACCGCA TGATCATCAT CACCGTTCTT CACGAGAATC GAGGTCACAA 540

CGCGACATAT ATGATCGTTC GGTGGAAAAG GTTTATTCAT CAAACCACCG AGACCGAAAT 600

GATCGGAGTC ATCGAACTTC TGACACTTCG GTTAGAGAAA CCTCTGAGTC AGGGCCTGAT 660

TCTCGCAGCC AAAGCAAGAG GACTACATCA CATTCACGGA GACCACCAGA CTCTCATGAT 720

GTACCTGACC ACCGCCAGGC TACAATGCCC CTACCTTCAG ACTCAAGAGA AAAATCGCGT 780

AAAAACAAGG ATTACTACAC CTACTCAAGC ACAGTTGATG TAAGACCACA AAATGAAAAT 840

ACGGTTGCCG AACACACGTA TCAGAATATT TCAAATGGTC ACCGTTCATC TGAGCAGACC 900

AACACTAATG AAAAGTCATT TAGAAGAGGG CAAGGTAATG TGTTATTAGT TAAATTTGAT 960

CTTCATCCGC TTAACATTAC AAAGTTAATT TCCAACATTC CACCACAGAG AAAGATGACC 1020

GCTTCCCACG TCCAACGAAC TGGTGATTAT ATTCTTCCAA ATAAATCTCC ATCCCCAAAC 1080

AAAATGAATT CCCCCGTCCA TATTCGTGGT TATAATGATC GGACGTACAC CAGAAAACCC 1140

GAACCTTTAA GTCCTGGAGT ATCTGTAGCC CCCCCTGCTG CTCAAAAAGC ACTTGGTACA 1200

AAACGAGACT CGCATGCCGT TACCAATGAC CAGTTTCGAG CTGCTTTACA GATGGTGGTA 1260

TGTCCTGGTG ACCCTCGGGA AAGTTTGGAG AACTTCCTAA AAATCGGGGA GGGGTCAACA 1320

GGGGTTGTCT GTATCGCTAA CGAGAAGGGT ACGGGGCGCC ACGTTGCTGT GAAGAAGATG 1380

AACGTTAGAA AACAACAAAG GAGAGAGCTT TTGTTTAATG AGGTGGTTAT AATGCGAGAC 1440

TACCACCATG AGAACATAGT TGATATGTAC AGCAGTTTCT TGGTGGATGA TGAATTATGG 1500

GTAGTAATGG AGTATATGGA GGGCGGTGCG CTTACAGATA TCGTGACGAG AACTCGCCTC 1560

AATGAGCAGC AGATAGCAAC CGTGTGTGTG TCGGTGTTGA ATGCACTTGC ATATCTTCAT 1620

GCGCAAGGTG TCATACACAG AGACATCAAA AGTGATTCGA TTTTATTAAC AAAAGATCTC 1680

ACGGTCAAAT TATCCGATTT TGGATTCTGC GCCCAAATTT CCTCCGATGT CCCGAAGCGT 1740

AAGTCGTTGG TTGGAACCCC ATACTGGATG GCCCCGGAGG TGGTTTCCCG CACCCCATAC 1800

GGCCCCGAAG TTGACATTTG GTCGCTGGGT ATCATGGTAA TGGAAATGGT GGACAAAGAA 1860

CCTCCCTATT TTGACGAAGC TCCCTTGCAA GCCATGCGTA AAATACGCGA CATGCCACCT 1920

CCAAAGTTAA AAAACGCACA TAAGGCTTCC CCACTCTTGA AAGGCTTCCT GGACCAAGTA 1980

TTAGTTCGTG ATCCATCTAC AAGATCAACT GCATTAGAGT TGCTGCAACA CCCATTCCTC 2040

AGAAAGTCTT CCTCGCATAA ATCCATCGGC CCCATCAGCT TACCAGGCAT CACAAGATAA 2100

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v++a+ek tg+ va+kk+n++kq++ e+l++e+ ++++++h+niv++++

Q: 432   FLKIGEGSTGVVCIANEKGTGRHVAVKKMNVRKQQRRELLFNEVVIMRDYHHENIVDMYS  491

         568*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         sfl+++elw+vmey++gG+l+d+v+   +++l+E+qia+++ +vl+aL+ylH+++viHrd

Q: 492   SFLVDDELWVVMEYMEGGALTDIVT---RTRLNEQQIATVCVSVLNALAYLHAQGVIHRD  548

         *************************...9*******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt++ +VkLsdfg++aq+++++ krk++vgtpywmAPEv++  ++ Y  ++Di

Q: 549   IKSDSILLTKDLTVKLSDFGFCAQISSDVPKRKSLVGTPYWMAPEVVS--RTPYGPEVDI  606

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI+++e+++ epP++d+ pl+a+ ki + +ppklk+ +k s+ +k f++++l ++p+

Q: 607   WSLGIMVMEMVDKEPPYFDEAPLQAMRKIRDMPPPKLKNAHKASPLLKGFLDQVLVRDPS  666

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a ell+h+Fl

Q: 667   TRSTALELLQHPFL  680

         *************7

Domain Sequence
(FASTA)

FLKIGEGSTG VVCIANEKGT GRHVAVKKMN VRKQQRRELL FNEVVIMRDY HHENIVDMYS 60

SFLVDDELWV VMEYMEGGAL TDIVTRTRLN EQQIATVCVS VLNALAYLHA QGVIHRDIKS 120

DSILLTKDLT VKLSDFGFCA QISSDVPKRK SLVGTPYWMA PEVVSRTPYG PEVDIWSLGI 180

MVMEMVDKEP PYFDEAPLQA MRKIRDMPPP KLKNAHKASP LLKGFLDQVL VRDPSTRSTA 240

LELLQHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013