EKS-CAJ-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.6	1.2E-134	277	526	250

Status

Unreviewed

Ensembl Protein

ENSCJAP00000000177

UniProt Accession

F7E686;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000000099	ENSCJAP00000043562	ENSCJAT00000061306
ENSCJAG00000000099	ENSCJAP00000000177	ENSCJAT00000000187

Organism

Callithrix jacchus

Functional Description

Protein Length

543

Protein Sequence
(FASTA)

MGCIKSKENK SPAIKYRPEN TSEPVSTSAS HYGAEPTAAS PCPSSSAKGT AVNFSSLSVT 60

PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI 120

INNTEGDWWE ARSIATGKNG YIPSNYVAPA DSIQAEEWYF GKMGRKDAER LLLNPGNQRG 180

IFLVRESETT KGAYSLSIRD WDEVRGDNVK HYKIRKLDNG GYYITTRAQF ETLQKLVKHY 240

TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT 300

KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL 360

KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL 420

IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE 480

VLEQVERGYR MPCPQGCPES LHDLMNQCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG 540

ENL 543

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TTAAATATAG ACCTGAAAAT 60

ACTTCAGAGC CTGTCAGTAC AAGTGCAAGC CATTATGGAG CAGAACCCAC TGCAGCGTCA 120

CCATGTCCAT CATCTTCAGC AAAGGGAACA GCAGTTAATT TCAGCAGTCT TTCCGTGACA 180

CCATTTGGAG GATCCTCAGG GGTAACACCT TTTGGAGGTG CATCTTCCTC ATTCTCAGTG 240

GTGCCAAGTT CATATCCTGC TGGTTTAACA GGTGGTGTTA CTATATTTGT GGCCTTATAT 300

GATTATGAAG CTAGAACTAC AGAAGATCTT TCATTTAAGA AGGGTGAAAG ATTTCAAATA 360

ATTAACAATA CGGAAGGAGA CTGGTGGGAA GCAAGATCAA TCGCTACAGG AAAGAATGGT 420

TATATCCCAA GCAATTATGT AGCACCTGCA GATTCCATTC AGGCAGAAGA ATGGTATTTT 480

GGCAAAATGG GGAGAAAAGA TGCTGAAAGA TTACTCCTGA ATCCTGGAAA TCAACGAGGT 540

ATTTTCTTAG TAAGAGAGAG TGAAACTACT AAAGGTGCTT ATTCCCTCTC TATTCGTGAT 600

TGGGATGAGG TAAGGGGTGA CAATGTGAAG CACTACAAAA TTAGGAAACT TGACAATGGT 660

GGATACTATA TCACAACTAG AGCACAATTT GAAACTCTGC AGAAATTGGT AAAACACTAC 720

ACAGAACATG CTGATGGTTT ATGCCACAAG TTAACCACTG TATGTCCAAC TGTGAAACCT 780

CAGACTCAAG GTCTAGCAAA AGATGCTTGG GAAATCCCTC GAGAATCTTT GCGACTAGAG 840

GTTAAACTAG GACAAGGATG CTTTGGCGAA GTGTGGATGG GAACATGGAA TGGAACCACA 900

AAAGTAGCAA TCAAAACACT AAAACCAGGT ACAATGATGC CAGAAGCTTT TCTTCAAGAA 960

GCTCAGATAA TGAAAAAATT AAGACATGAT AAACTTGTTC CACTATATGC TGTTGTTTCT 1020

GAAGAGCCAA TTTACATTGT CACTGAATTT ATGTCAAAAG GAAGCTTACT AGATTTCCTT 1080

AAGGAAGGAG ATGGAAAGTA TTTGAAGCTT CCACAACTAG TTGATATGGC TGCTCAGATT 1140

GCTGATGGTA TGGCATATAT TGAAAGAATG AACTATATTC ACCGAGATCT TCGGGCTGCT 1200

AATATTCTTG TAGGTGAAAA TCTTGTGTGC AAAATAGCGG ATTTTGGTTT AGCAAGGTTA 1260

ATCGAAGACA ATGAATACAC AGCAAGACAA GGTGCAAAAT TTCCAATCAA ATGGACAGCC 1320

CCTGAAGCTG CACTGTATGG TCGGTTTACA ATAAAGTCTG ATGTCTGGTC ATTTGGAATT 1380

CTACAGACAG AACTGGTAAC AAAGGGCAGA GTGCCATATC CAGGTATGGT GAACCGTGAA 1440

GTACTGGAAC AGGTGGAGCG AGGATACAGG ATGCCCTGCC CTCAGGGCTG TCCAGAATCC 1500

CTCCATGACT TGATGAATCA GTGTTGGAAG AAGGACCCTG ATGAAAGACC AACATTTGAA 1560

TATATTCAGT CCTTCTTGGA AGACTACTTC ACTGCCACAG AGCCACAGTA CCAGCCAGGA 1620

GAAAATTTAT AA 1632

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 277   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  336

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 337   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  395

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 396   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  455

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l++l+++cwkkdp+e

Q: 456   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHDLMNQCWKKDPDE  515

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 516   RPTFEYIQSFL  526

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHDLMN QCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013