EKS-CAJ-00004

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00004

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	516.1	2.6E-155	633	889	257

Status

Unreviewed

Ensembl Protein

ENSCJAP00000001951

UniProt Accession

F6XPG2;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA7

Gene Synonyms/Alias

EPHA7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000001086	ENSCJAP00000001951	ENSCJAT00000002066

Organism

Callithrix jacchus

Functional Description

Protein Length

998

Protein Sequence
(FASTA)

MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 60

LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120

ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180

GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240

EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 300

FSDKEGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 360

NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 420

VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 480

YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATG 540

KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 600

KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 660

AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 720

AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 780

RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 840

SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPNSL 900

KTPLGTCSRP ISPLLDQNTP DFTTFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 960

EDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV 998

Nucleotide Sequence
(FASTA)

ATGGTTTTTC AAACTCGGTA CCCTTCATGG ATTATTTTAT GCTACATCTG GCTGCTCCGC 60

TTTGCACACA CGGGGGAGGC GCAGGCTGCG AAGGAAGTTC TACTGCTGGA TTCTAAAGCA 120

CAACAAACAG AGTTGGAGTG GATTTCCTCT CCACCTAATG GGTGGGAAGA AATTAGTGGT 180

TTGGATGAGA ACTATACCCC CATACGAACA TACCAGGTGT GCCAAGTCAT GGAACCCAAC 240

CAAAACAACT GGCTGCGGAC TAACTGGATT TCAAAAGGCA ATGCACAAAG GATTTTTGTA 300

GAATTGAAAT TCACCCTGAG GGATTGTAAC AGTCTTCCTG GAGTACTGGG AACTTGCAAG 360

GAAACATTTA ATTTGTACTA TTATGAAACA GACTATGACA CTGGCAGGAA TATAAGAGAA 420

AACCTCTATG TAAAAATAGA CACCATTGCG GCAGATGAAA GTTTTACCCA AGGTGACCTT 480

GGTGAAAGAA AGATGAAGCT TAACACTGAG GTGAGAGAGA TTGGACCTTT GTCCAAAAAG 540

GGATTCTATC TTGCCTTTCA GGATGTAGGG GCTTGCATAG CTTTGGTTTC TGTCAAAGTG 600

TACTACAAGA AGTGCTGGTC CATTATTGAG AACTTAGCTA TCTTTCCAGA TACAGTGACT 660

GGTTCAGAAT TTTCCTCTTT AGTCGAGGTT CGAGGGACAT GTGTCAGCAG TGCAGAGGAA 720

GAGGCGGAAA ACTCCCCCAG GATGCACTGC AGTGCAGAAG GAGAATGGTT AGTGCCCATT 780

GGAAAATGTA TCTGCAAAGC GGGCTACCAG CAAAAAGGGG ACACTTGTGA ACCCTGTGGC 840

CGTGGGTTCT ACAAGTCTTC CTCTCAAGAT CTTCAGTGCT CTCGTTGTCC AACTCACAGT 900

TTTTCTGATA AAGAAGGCTC CTCCAGATGT GAATGTGAAG ATGGGTATTA CAGGGCTCCA 960

TCTGACCCAC CGTACGTTGC ATGCACAAGG CCTCCATCTG CACCACAGAA CCTCATTTTC 1020

AACATCAACC AAACCACAGT AAGTTTGGAA TGGAGTCCTC CTGCAGACAA TGGGGGAAGA 1080

AATGATGTGA CCTACAGAAT ATTGTGTAAG CGGTGCAGTT GGGAGCAGGG TGAATGTGTT 1140

CCCTGTGGGA GTAACATCGG ATACATGCCC CAGCAGACTG GATTAGAGGA CAACTATGTC 1200

ACTGTCATGG ACCTGCTAGC CCACGCTAAT TATACTTTTG AAGTTGAAGC TGTAAATGGA 1260

GTTTCTGACT TAAGTCGATC CCAGAGGCTC TTTGCGGCTG TCAGTATCAC CACTGGTCAA 1320

GCAGCTCCCT CGCAAGTGAG CGGAGTAATG AAGGAGAGAG TGCTGCAGCG GAGTGTCGAG 1380

CTTTCCTGGC AGGAACCAGA GCATCCCAAT GGAGTCATCA CAGAATATGA AATAAAGTAT 1440

TACGAGAAAG ATCAAAGGGA ACGGACCTAC TCAACAGTAA AAACCAAGTC TACTTCAGCT 1500

TCCATTAATA ATCTGAAACC AGGAACAGTG TATGTTTTCC AGATTCGAGC TTTTACTGCT 1560

GCAGGTTATG GAAATTACAG CCCCAGACTT GATGTTGCTA CACTAGAGGA AGCTACAGGT 1620

AAAATGTTTG AAGCTACAGC TGTCTCCAGT GAACAGAATC CTGTCATTAT CATTGCTGTG 1680

GTTGCTGTGG CTGGGACCAT CATTTTGGTG TTCATGGTCT TTGGCTTCAT CATTGGGAGA 1740

AGGCACTGTG GTTATAGCAA AGCTGACCAA GAAGGGGATG AAGAGCTTTA CTTTCACTTT 1800

AAATTTCCAG GCACCAAAAC CTACATTGAC CCTGAAACCT ATGAGGACCC AAATAGAGCT 1860

GTCCATCAAT TCGCCAAGGA GCTAGATGCC TCCTGTATTA AAATTGAGCG CGTGATTGGT 1920

GCAGGAGAAT TTGGTGAAGT CTGCAGTGGC CGTTTGAAAC TTCCAGGAAA AAGAGATGTT 1980

GCAGTAGCCA TAAAAACCCT CAAAGTTGGT TACACAGAAA AACAAAGGAG AGACTTTTTA 2040

TGTGAAGCAA GCATCATGGG GCAGTTTGAC CACCCAAATG TTGTCCATTT GGAAGGGGTT 2100

GTCACAAGAG GGAAACCAGT CATGATTGTA ATAGAATTCA TGGAGAATGG AGCCCTAGAT 2160

GCCTTTCTCA GGAAACATGA TGGGCAATTT ACAGTCATTC AGTTAGTAGG AATGCTGAGA 2220

GGAATTGCTG CTGGAATGAG ATATTTGGCT GATATGGGAT ATGTTCACAG GGACCTTGCA 2280

GCTCGCAATA TTCTTGTCAA CAGCAATCTC GTTTGTAAAG TGTCAGATTT TGGCCTGTCC 2340

CGAGTTATAG AGGATGATCC AGAAGCTGTC TATACAACTA CTGGTGGAAA AATTCCGGTA 2400

AGGTGGACAG CACCTGAAGC CATCCAGTAC CGGAAGTTCA CATCAGCCAG TGATGTATGG 2460

AGCTATGGAA TAGTCATGTG GGAAGTTATG TCTTATGGAG AAAGACCTTA TTGGGACATG 2520

TCAAATCAAG ATGTTATAAA AGCAATAGAA GAAGGTTATC GTTTACCAGC ACCCATGGAC 2580

TGCCCAGCTG GTCTTCACCA GCTCATGTTG GACTGTTGGC AAAAAGAGCG TGCTGAAAGG 2640

CCAAAATTTG AACAGATAGT TGGAATTCTA GACAAAATGA TTCGAAACCC AAATAGTCTG 2700

AAAACTCCCC TGGGAACTTG TAGTAGGCCA ATAAGCCCTC TTCTGGATCA AAACACTCCG 2760

GATTTCACTA CCTTTTGTTC AGTTGGAGAA TGGCTACAAG CTATTAAGAT GGAAAGATAT 2820

AAAGATAACT TCACAGCGGC TGGCTACAAT TCCCTTGAAT CAGTAGCCAG GATGACTATT 2880

GAGGATGTGA TGAGTTTAGG GATCACACTG GTTGGCCATC AAAAGAAAAT CATGAGCAGC 2940

ATTCAGACTA TGAGAGCACA AATGCTACAT TTACATGGAA CTGGCATTCA AGTGTGA 2997

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp

Q: 633   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  692

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+++leGvvt++kpvmiv+e+mengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm

Q: 693   NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  752

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk

Q: 753   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  812

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc

Q: 813   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  872

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqk+raerpkfeqiv i

Q: 873   WQKERAERPKFEQIVGI  889

         **************987

Domain Sequence
(FASTA)

IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60

NVVHLEGVVT RGKPVMIVIE FMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120

GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240

WQKERAERPK FEQIVGI 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013