EKS-CAJ-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	486.0	5.4E-146	478	749	272

Status

Unreviewed

Ensembl Protein

ENSCJAP00000002608

UniProt Accession

F7I6U1;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000001438	ENSCJAP00000002608	ENSCJAT00000002753

Organism

Callithrix jacchus

Functional Description

Protein Length

813

Protein Sequence
(FASTA)

VWTWAHSTQW LHFRTLKTAC LSSPSTELEP PTKYQISQPE VYVAAPGESL EVRCLLKDAA 60

VISWTKDGVH LGPNNRTVLI GEYLQIKGAT PRDSGLYACT ATRTVDSETW YFMVNVTDAI 120

SSGDDEDDTD GAEDFVSEST NNETNSVLAM PSPCKPGSFK NILQVIPSAD MILYRVQKAW 180

APNAVAKIIK NCKKERTFHR ISGYEVRNQH WSLIMESVVP SDKGNYTCVV ENEYGSINHT 240

YHLDVVERSP HRPILQAGLP ANASTVVGGD VEFVCKVYSD AQPHIQWIKH VEKNGSKYGP 300

DGLPYLKVLK AAGVNTTDKE IEVLYIRNVT FEDAGEYTCL AGNSIGISFH SAWLTVLPAP 360

IREKETTASP DYLEIAIYCI GVFLIACMVV TVILCRMKNT TKKPDFSSQP AVHKLTKRIP 420

LRRQVTVSAE SSSSMNSNTP LVRITTRLSS TADTPMLAGV SEYELPEDPK WEFPRDKLTL 480

GKPLGEGCFG QVVMAEAVGI DKDKPKEAVT VAVKMLKDDA TEKDLSDLVS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLRARRPPG MEYSYDINRV PEEQMTFKDL 600

VSCTYQLARG MEYLASQKCI HRDLAARNVL VTENNVMKIA DFGLARDINN IDYYKKTTNG 660

RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLM WEIFTIGGLS KPIIKINSSA ALVQGREDKT 720

NPRKYMMMRD CWHAVPSQRP TFKQLVEDLD RILTLTTNEE YLDLSQPLEQ YSPSYPDTRS 780

SCSSGDDSVF SPDPMPYEPC LPQYPHINGS VKT 813

Nucleotide Sequence
(FASTA)

GTGTGGACTT GGGCACACAG CACCCAGTGG CTTCATTTCA GGACCCTGAA AACAGCATGT 60

CTCAGCTCAC CCAGCACAGA ATTAGAGCCA CCAACCAAAT ACCAAATCTC TCAACCAGAA 120

GTGTACGTGG CTGCGCCAGG GGAGTCGCTA GAGGTGCGCT GCCTGTTGAA AGATGCCGCT 180

GTGATCAGTT GGACTAAGGA TGGGGTGCAC TTGGGGCCCA ACAATAGGAC AGTGCTTATT 240

GGGGAGTACT TGCAGATCAA GGGCGCCACG CCTAGGGACT CCGGCCTCTA TGCTTGTACT 300

GCCACTAGGA CTGTAGACAG TGAAACTTGG TACTTCATGG TGAATGTCAC AGATGCCATC 360

TCATCTGGGG ATGATGAGGA TGACACCGAT GGCGCGGAAG ATTTTGTCAG TGAGAGCACT 420

AACAACGAGA CCAACAGTGT ACTTGCCATG CCTTCACCTT GCAAGCCGGG TTCTTTTAAA 480

AACATATTAC AGGTTATTCC CTCTGCTGAT ATGATTCTGT ACAGAGTGCA AAAAGCTTGG 540

GCGCCAAATG CAGTGGCAAA AATAATCAAG AATTGTAAAA AAGAAAGGAC ATTCCACAGG 600

ATCAGTGGTT ATGAGGTACG CAACCAGCAC TGGAGCCTCA TTATGGAAAG CGTGGTCCCG 660

TCTGACAAGG GAAATTATAC CTGCGTGGTG GAGAATGAGT ACGGGTCCAT CAATCACACG 720

TACCACCTGG ATGTTGTGGA GCGATCACCT CACCGGCCCA TCCTCCAAGC CGGACTGCCA 780

GCAAATGCCT CCACGGTGGT CGGAGGAGAC GTGGAGTTTG TGTGCAAGGT TTACAGTGAT 840

GCTCAGCCCC ACATCCAGTG GATCAAGCAC GTGGAAAAGA ATGGCAGTAA ATATGGGCCT 900

GATGGGCTGC CCTACCTCAA GGTTCTCAAG GCTGCCGGTG TTAACACCAC GGACAAAGAG 960

ATTGAGGTTC TCTATATTCG GAATGTAACT TTTGAGGACG CTGGGGAATA TACGTGCTTG 1020

GCGGGTAATT CTATTGGGAT ATCCTTTCAC TCTGCATGGT TGACAGTTCT GCCAGCTCCC 1080

ATAAGAGAAA AGGAGACTAC AGCTTCCCCA GACTACCTGG AGATAGCCAT TTACTGCATA 1140

GGGGTCTTCT TAATCGCCTG TATGGTGGTG ACAGTTATCC TGTGCCGAAT GAAGAACACG 1200

ACCAAGAAGC CAGACTTCAG CAGCCAGCCG GCTGTGCACA AGCTGACCAA GCGCATCCCC 1260

CTGCGGAGAC AGGTAACAGT TTCGGCTGAG TCCAGCTCCT CCATGAACTC CAACACCCCG 1320

CTGGTGAGGA TAACAACACG CCTCTCTTCA ACGGCAGACA CCCCCATGCT GGCAGGGGTC 1380

TCTGAGTATG AACTTCCAGA GGACCCAAAA TGGGAGTTTC CAAGAGATAA GCTGACACTG 1440

GGCAAGCCCC TGGGAGAAGG TTGCTTTGGG CAAGTGGTCA TGGCGGAAGC AGTGGGAATT 1500

GACAAAGACA AGCCCAAGGA GGCAGTCACC GTGGCAGTGA AGATGTTGAA AGATGATGCC 1560

ACAGAGAAAG ACCTTTCTGA TCTGGTGTCA GAGATGGAGA TGATGAAGAT GATTGGGAAA 1620

CACAAAAATA TCATAAATCT TCTTGGAGCC TGCACACAGG ATGGACCTCT CTATGTCATA 1680

GTTGAGTATG CCTCTAAAGG CAACCTCCGA GAATACCTCC GAGCCCGGAG GCCACCAGGG 1740

ATGGAGTACT CCTATGACAT TAACCGTGTT CCTGAGGAGC AGATGACCTT CAAGGACTTG 1800

GTGTCATGCA CCTACCAGCT GGCCAGAGGC ATGGAGTACT TGGCTTCCCA AAAATGTATT 1860

CATCGAGATT TAGCAGCCAG AAATGTTTTG GTAACTGAAA ACAATGTGAT GAAAATAGCA 1920

GACTTTGGAC TGGCCAGAGA TATCAACAAC ATAGACTATT ACAAAAAGAC CACGAATGGG 1980

CGACTTCCAG TCAAGTGGAT GGCTCCAGAA GCCCTTTTTG ATAGAGTATA CACTCATCAG 2040

AGTGATGTCT GGTCCTTTGG GGTGTTAATG TGGGAGATCT TCACTATAGG GGGTCTGTCA 2100

AAACCTATAA TCAAGATAAA TAGTAGTGCT GCTTTGGTGC AGGGGAGGGA AGACAAGACC 2160

AATCCACGGA AGTACATGAT GATGAGGGAC TGTTGGCATG CAGTGCCCTC CCAGAGACCA 2220

ACGTTCAAGC AGTTGGTGGA AGACTTGGAT CGAATTCTCA CTCTCACAAC CAATGAGGAA 2280

TACCTGGACC TCAGTCAGCC CCTCGAACAG TATTCACCTA GTTACCCTGA CACAAGAAGT 2340

TCTTGTTCTT CAGGAGATGA TTCTGTTTTT TCTCCAGACC CCATGCCTTA TGAACCATGC 2400

CTTCCTCAGT ATCCACACAT CAACGGCAGT GTTAAAACAT GA 2442

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 478   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 598   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+t+Gg   p i ++   +l  +G+

Q: 658   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTIGGLSKPIIKINSSAAL-VQGR  716

         *************************************************987665.5553

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

           +   k +   y++mr+cwha++s+rptfkqlvedl

Q: 717   -ED---KTNPRKYMMMRDCWHAVPSQRPTFKQLVEDL  749

         .33...334456***********************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTIG GLSKPIIKIN SSAALVQGRE 240

DKTNPRKYMM MRDCWHAVPS QRPTFKQLVE DL 272

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013