EKS-CAJ-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	332.3	4.8E-99	22	312	291

Status

Unreviewed

Ensembl Protein

ENSCJAP00000047130

UniProt Accession

F7HUR1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000001974	ENSCJAP00000047130	ENSCJAT00000054590
ENSCJAG00000001974	ENSCJAP00000003575	ENSCJAT00000003765

Organism

Callithrix jacchus

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MAEKSDCIAS VYGYDLGGRF VDFRPLGFGV NGLVLSAVDS RACRKVAVKK IALSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV AYIIQEYMET DLARLLEQGT 120

LAEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKEDLLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSKHPFRI EDEIDDIVLM AANQSQLSNW DRCSSRYPVS 360

LSSDLEWRPE RCQDASEVQR DPRAGSAPLA EDVQVDPRKD SHSSSERFLE QSHSSMERAF 420

EADYGRSCDY KVGSPSYLDK LLWRDNKPHH YSEPKLILDL SHWKQAAGAP PTATGPTDAG 480

TREDEPASLF LEIAQWVKST QGGPEHASPP ADDPECHGSA SPPGCPAPMD GGASPQFDLD 540

VFISRALKLC TKPEDLPDNK LGDLNGACIP EHPGDLVQTE AFSKERW 587

Nucleotide Sequence
(FASTA)

ATGGCTGAAA AGAGTGACTG CATCGCCAGT GTCTACGGGT ATGACCTCGG TGGGCGCTTT 60

GTTGACTTCC GACCCCTGGG CTTCGGTGTC AATGGTCTGG TGCTGTCAGC CGTGGACAGC 120

CGGGCCTGCC GGAAGGTCGC CGTGAAGAAG ATTGCCCTGA GCGATGCCCG CAGCATGAAG 180

CACGCTCTCC GAGAGATCAA GATCATCCGG CGCCTGGACC ACGACAACAT CGTCAAAGTG 240

TATGAGGTGC TCGGGCCCAA GGGCACCGAT CTGCAGGGTG AGCTGTTCAA GTTCAGCGTG 300

GCCTACATCA TCCAGGAGTA CATGGAGACT GACCTGGCAC GCCTGCTGGA GCAGGGCACC 360

CTGGCAGAAG AGCATGCCAA ACTGTTCATG TACCAGCTGC TCCGCGGGCT CAAGTACATC 420

CACTCTGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAA 480

GACCTCGTGC TCAAGATTGG GGATTTCGGG TTGGCAAGGA TCGTGGATCA GCATTACTCC 540

CACAAGGGTT ATCTGTCAGA AGGGTTGGTA ACGAAGTGGT ACCGCTCCCC ACGACTGCTT 600

CTCTCCCCCA ATAACTACAC CAAAGCCATT GACATGTGGG CCGCCGGCTG CATCCTGGCC 660

GAGATGCTTA CAGGGAGAAT GCTCTTTGCT GGGGCCCATG AGCTGGAGCA GATGCAACTC 720

ATCCTGGAGA CCATCCCTGT GATCCGGGAG GAAGACAAGG AAGACCTGCT CAGGGTGATG 780

CCCTCCTTCG TCAGCAGCAC CTGGGAAGTG AAGAGGCCTC TGCGCAAGCT GCTCCCCGAA 840

GTGAACAGTG AAGCCATCGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTAACAGCTG AGATGGGGCT GCAGCACCCC TACATGAGCC CATACTCATG TCCCGAGGAC 960

GAGCCCACCT CGAAACACCC TTTCCGCATT GAGGATGAGA TCGACGACAT CGTGCTGATG 1020

GCTGCTAACC AGAGCCAGCT CTCCAACTGG GACAGGTGCA GTTCCAGGTA CCCTGTAAGC 1080

CTGTCATCGG ACCTGGAGTG GCGGCCCGAA CGGTGCCAGG ATGCCAGCGA GGTGCAGCGT 1140

GACCCGCGTG CGGGTTCGGC GCCCCTGGCC GAGGACGTGC AGGTGGACCC GCGCAAGGAC 1200

TCGCACAGCA GCTCCGAGCG CTTCCTGGAG CAGTCACACT CGTCCATGGA GCGGGCCTTC 1260

GAGGCCGACT ACGGGCGCTC CTGCGACTAC AAGGTGGGGT CTCCGTCCTA CCTGGACAAG 1320

CTGCTGTGGC GCGACAACAA GCCACACCAC TACTCGGAGC CCAAGCTCAT CCTGGACCTG 1380

TCGCACTGGA AGCAGGCGGC CGGCGCACCC CCCACGGCCA CAGGGCCGAC AGACGCGGGG 1440

ACACGCGAGG ACGAGCCGGC CAGCCTCTTC CTGGAGATCG CGCAGTGGGT CAAGAGCACG 1500

CAGGGCGGCC CCGAGCACGC CAGCCCACCT GCCGATGACC CCGAGTGCCA CGGGTCTGCC 1560

TCGCCCCCTG GCTGCCCAGC CCCCATGGAC GGCGGTGCCA GCCCCCAGTT CGACCTGGAC 1620

GTGTTCATCT CCCGCGCCCT GAAGCTCTGT ACCAAGCCTG AGGACCTGCC GGACAATAAA 1680

CTAGGCGACC TCAACGGTGC GTGCATCCCC GAGCACCCTG GCGACCTCGT GCAGACCGAG 1740

GCCTTCTCCA AAGAAAGGTG GTGA 1764

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+savd+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFRPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+++e+metdL++++++ +l +eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELFKFSVAYIIQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKY  139

         *******9888888899*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKEDLLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFVSSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFRPLGFGVN GLVLSAVDSR ACRKVAVKKI ALSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELFKFSVA YIIQEYMETD LARLLEQGTL AEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKEDLLRVMP 240

SFVSSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013