EKS-CAJ-00396

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00396

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	7.6E-97	1078	1342	265

Status

Unreviewed

Ensembl Protein

ENSCJAP00000003848

UniProt Accession

B0KW96;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 1 (Predicted);

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000002136	ENSCJAP00000003848	ENSCJAT00000004055
ENSCJAG00000002136	ENSCJAP00000003845	ENSCJAT00000004052

Organism

Callithrix jacchus

Functional Description

Protein Length

1347

Protein Sequence
(FASTA)

REMENKETLK GLHKMDDRPE ERMIREKLKA TCMPAWKHEW LERRNRRGPV VVKPIPVKGD 60

GSEMNHLAAE SPGEAQASAA SSASKGRRSP SPGNSPSGRP VKSESPGVRR KRVSPVPFQS 120

GRITPPRRAP SPDGFSPYSP EETNRRVNKV MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF 180

IGPQNCSCGR GTFCIHLLFV MLRVFQLEPS DPMLWRKTLK NFEVESLFQK YHSRRSSRIK 240

APSRNTIQKF VSRMSNSHTL SSSSTSTSSS ENSIKDEEEQ MCPICLLGML DEESLTVCED 300

GCRNKLHHHC MSIWAEECRR NREPLICPLC RSKWRSHDFY SHELSSPVDS PSSLRAAQQQ 360

TIQQQPLAGS QRRNQESNFN LTHYGTQQIP PAYKDLAEPW IQVFGMELVG CLFSRNWNVR 420

EMALRRLSHD VSGALLLANG ESTGNSGGSS GSSPSGGATS GSSQTSISGD VVEACCNVLS 480

MVCADPVYKV YVAALKTLRA MLVYTPCHSL AERIKLQRLL RPVVDTILVK CADANSRTSQ 540

LSISTLLELC KGQAGELAVG REILKAGSIG IGGVDYVLNC ILGNQTESNN WQELLGRLCL 600

IDRLLLEFPA EFYPHIVSTD VSQAEPVEIR YKKLLSLLTF ALQSIDNSHS MVGKLSRRIY 660

LSSARMVTAV PHVFSKLLEM LSVSSSTHFT RMRRRLMAIA DEVEIAEAIE LGVEDNLDSQ 720

QDGFLQASVP SNYPETTENS SPECTIHLDK TGKGLCATKL SASSENISDR LASISLGPPS 780

STTTEQPKPM VQTKGRPHSQ CLNSSPLSHH SQLMFPALST PSSSAPSVPA GTATDVSKHR 840

LQGFVPCKIP SASPQTQRKF SLQFQRNCPE NKDSDKLSPV FTQSRPLPSS NIHRPKPSRP 900

TPGNTSKQGD PSKNSMTLDL NSSSKCDDSF GCSSNSSNAV IPSDETVFTP VEEKCRLDVN 960

TELNSSIEDL LEASMPSSDT TVTFKSEVAV LSPEKAENDD TYKDDVNHNQ KCKEKMEAEE 1020

EEALAIAMAM SASQDALPIV PQLQVENGED IIIIQQDTPE TLPGHTKAKQ PYREDTEWLK 1080

GQQIGLGAFS SCYQAQDVGT GTLMAVKQVT YVRNTSSEQE EVVEALREEI RMMSHLNHPN 1140

IIRMLGATCE KSNYNLFIEW MAGGSVAHLL SKYGAFKESV VINYTEQLLR GLSYLHENQI 1200

IHRDVKGANL LIDSTGQRLR IADFGAAARL ASKGTGAGEF QGQLLGTIAF MAPEVLRGQQ 1260

YGRSCDVWSV GCAIIEMACA KPPWNAEKHS NHLALIFKIA SATTAPSIPS HLSPGLRDVA 1320

LRCLELQPQD RPPSRELLKH PVFRTTW 1347

Nucleotide Sequence
(FASTA)

CGTGAGATGG AGAATAAAGA AACTCTCAAA GGGTTGCACA AGATGGACGA TCGCCCAGAG 60

GAACGAATGA TCAGGGAGAA ACTGAAGGCA ACCTGTATGC CAGCCTGGAA GCACGAATGG 120

TTAGAAAGGA GAAATAGGCG AGGCCCTGTG GTGGTAAAAC CAATCCCAGT CAAAGGAGAT 180

GGATCTGAAA TGAATCACTT GGCAGCTGAG TCTCCAGGAG AGGCCCAGGC GAGTGCAGCT 240

TCATCAGCTT CCAAAGGCCG ACGCAGTCCT TCTCCTGGCA ACTCCCCATC AGGTCGCCCG 300

GTGAAATCAG AATCTCCGGG AGTAAGGCGA AAAAGAGTTT CCCCAGTGCC TTTTCAGAGT 360

GGCAGAATCA CACCACCCCG AAGAGCCCCT TCACCAGATG GCTTCTCACC ATACAGCCCT 420

GAGGAAACAA ATCGCCGTGT TAACAAAGTG ATGCGGGCCA GATTGTACTT ACTGCAGCAG 480

ATAGGGCCCA ACTCTTTCCT GATTGGAGGA GACAGCCCAG ACAATAAATA CCGGGTGTTT 540

ATTGGACCTC AGAACTGCAG CTGTGGGCGT GGAACATTCT GTATTCATCT GCTGTTTGTG 600

ATGCTCCGGG TGTTTCAGCT AGAACCTTCA GACCCAATGT TATGGAGAAA AACTTTAAAG 660

AATTTTGAGG TTGAGAGTTT GTTCCAGAAA TATCACAGTA GGCGTAGCTC AAGGATCAAA 720

GCTCCATCTC GTAACACCAT CCAGAAGTTT GTTTCACGCA TGTCAAATTC TCATACATTG 780

TCATCATCTA GTACTTCTAC ATCTAGTTCA GAAAACAGCA TAAAGGATGA AGAGGAACAG 840

ATGTGTCCTA TTTGTTTATT GGGCATGCTT GATGAAGAAA GTCTTACAGT GTGTGAAGAC 900

GGCTGCAGGA ACAAGCTGCA CCATCACTGC ATGTCAATTT GGGCAGAAGA GTGTAGAAGA 960

AATAGAGAAC CTTTAATATG TCCCCTTTGT AGATCTAAGT GGAGATCTCA TGATTTCTAC 1020

AGCCATGAGT TGTCAAGTCC TGTGGATTCC CCTTCTTCCC TCAGAGCTGC ACAGCAGCAA 1080

ACTATACAGC AGCAGCCTTT GGCTGGATCA CAGAGAAGGA ATCAAGAGAG CAATTTTAAC 1140

CTTACTCATT ATGGAACTCA GCAAATCCCT CCTGCTTACA AAGATTTAGC TGAGCCATGG 1200

ATTCAGGTGT TTGGAATGGA ACTCGTTGGC TGCTTATTTT CTAGAAACTG GAATGTGAGA 1260

GAGATGGCCC TCAGGCGTCT TTCCCATGAT GTCAGTGGGG CCCTGCTGTT GGCAAATGGG 1320

GAGAGCACTG GAAACTCTGG GGGCAGCAGT GGAAGCAGCC CGAGTGGGGG AGCCACCAGT 1380

GGGTCTTCCC AGACCAGTAT CTCAGGAGAT GTGGTGGAGG CGTGCTGCAA CGTTCTGTCA 1440

ATGGTCTGTG CCGACCCTGT CTACAAAGTG TACGTTGCTG CTTTAAAAAC GTTGAGAGCC 1500

ATGCTGGTAT ATACTCCTTG CCACAGTTTA GCAGAAAGAA TCAAACTTCA GAGACTTCTC 1560

CGGCCAGTTG TAGACACCAT CCTAGTCAAA TGTGCAGATG CCAATAGCCG CACAAGTCAG 1620

CTGTCCATAT CAACATTGTT GGAGTTGTGC AAAGGCCAAG CAGGAGAGTT GGCAGTTGGT 1680

AGAGAAATAC TAAAAGCTGG ATCCATTGGT ATTGGTGGTG TTGATTATGT CTTAAATTGT 1740

ATTCTTGGAA ACCAAACTGA ATCAAACAAC TGGCAAGAAC TCCTTGGCCG CCTTTGTCTT 1800

ATAGACAGAC TGTTGTTGGA ATTTCCTGCT GAATTTTATC CTCATATTGT CAGTACTGAT 1860

GTTTCACAAG CTGAGCCTGT TGAAATCAGG TATAAGAAGC TGCTGTCCCT CTTAACCTTT 1920

GCTTTACAGT CCATTGATAA TTCTCACTCA ATGGTTGGTA AACTTTCCAG AAGGATCTAC 1980

TTGAGTTCTG CAAGAATGGT CACTGCAGTA CCCCATGTGT TTTCAAAACT GTTAGAAATG 2040

CTGAGTGTTT CCAGTTCCAC TCACTTCACC AGGATGCGTC GCCGTTTGAT GGCTATTGCA 2100

GATGAGGTGG AAATTGCTGA AGCCATCGAG TTGGGCGTAG AAGACAATTT GGATAGTCAA 2160

CAGGATGGCT TTTTGCAGGC ATCTGTCCCC AGCAACTATC CAGAAACCAC AGAGAACAGT 2220

TCCCCTGAGT GTACAATCCA TTTAGACAAA ACTGGAAAAG GATTATGTGC TACAAAATTG 2280

AGTGCCAGTT CAGAGAACAT TTCTGACAGA CTGGCCAGCA TTTCACTAGG ACCTCCTAGT 2340

TCAACAACAA CAGAGCAACC AAAGCCAATG GTTCAAACAA AAGGCAGACC CCACAGTCAG 2400

TGTTTGAACT CCTCTCCTTT ATCTCATCAT TCCCAATTAA TGTTCCCAGC CTTGTCAACC 2460

CCTTCTTCTT CAGCCCCATC TGTACCAGCT GGCACTGCAA CAGATGTCTC TAAGCATAGA 2520

CTTCAGGGAT TCGTTCCCTG CAAAATACCT TCTGCATCTC CTCAAACACA GCGCAAGTTT 2580

TCTCTACAAT TCCAGAGAAA CTGTCCTGAA AACAAAGACT CAGATAAACT TTCCCCAGTC 2640

TTTACTCAGT CAAGACCCTT GCCCTCCAGT AACATACACA GGCCAAAGCC ATCTCGACCT 2700

ACCCCAGGTA ATACAAGTAA ACAGGGAGAT CCCTCAAAAA ATAGCATGAC ACTTGATCTG 2760

AACAGTAGTT CCAAATGTGA TGACAGCTTT GGCTGTAGCA GCAATAGTAG TAATGCTGTT 2820

ATACCCAGTG ATGAGACAGT GTTCACCCCA GTAGAGGAGA AATGCAGATT AGATGTCAAT 2880

ACAGAGCTCA ACTCCAGTAT TGAGGACCTT CTTGAAGCAT CTATGCCTTC AAGTGATACA 2940

ACAGTAACTT TTAAGTCAGA AGTTGCTGTC CTGTCTCCTG AAAAGGCTGA AAATGATGAT 3000

ACCTACAAAG ATGATGTGAA TCATAATCAG AAGTGCAAAG AAAAGATGGA AGCTGAAGAA 3060

GAAGAAGCTT TAGCAATTGC CATGGCAATG TCAGCGTCTC AGGATGCCCT CCCCATAGTT 3120

CCTCAGCTGC AGGTTGAAAA TGGAGAAGAT ATCATCATTA TTCAACAGGA TACACCAGAG 3180

ACTCTACCAG GACATACCAA AGCAAAACAA CCATATAGAG AAGACACTGA ATGGCTGAAA 3240

GGTCAGCAGA TAGGCCTTGG AGCATTTTCT TCTTGTTACC AGGCTCAAGA TGTGGGAACT 3300

GGAACTTTAA TGGCTGTTAA ACAGGTGACG TATGTCAGGA ACACATCTTC TGAGCAAGAA 3360

GAAGTGGTAG AAGCATTAAG AGAAGAGATA AGAATGATGA GCCATCTGAA TCATCCAAAC 3420

ATTATTAGGA TGTTGGGAGC CACGTGTGAG AAGAGCAATT ACAATCTCTT CATCGAATGG 3480

ATGGCAGGGG GATCTGTGGC TCATTTGCTG AGTAAATATG GAGCTTTCAA AGAATCAGTA 3540

GTTATTAACT ATACTGAACA GTTACTTCGT GGCCTTTCAT ATCTCCATGA AAACCAAATC 3600

ATTCACAGAG ATGTCAAAGG TGCCAATTTA CTAATTGACA GCACTGGTCA GAGACTAAGA 3660

ATTGCAGATT TTGGAGCTGC AGCCAGGTTG GCATCAAAAG GAACTGGTGC AGGAGAGTTT 3720

CAGGGACAGT TACTGGGGAC AATTGCGTTT ATGGCACCTG AGGTACTAAG AGGTCAACAG 3780

TATGGAAGGA GCTGTGATGT ATGGAGTGTT GGCTGTGCTA TTATAGAAAT GGCTTGTGCA 3840

AAACCACCAT GGAATGCAGA AAAACACTCC AATCATCTTG CTTTGATATT TAAGATTGCT 3900

AGTGCAACTA CTGCTCCATC GATCCCATCA CATCTGTCTC CCGGTTTACG AGATGTGGCT 3960

CTTCGTTGTT TAGAACTTCA ACCTCAGGAC AGACCTCCAT CAAGAGAGCT ACTGAAGCAT 4020

CCAGTCTTTC GTACTACATG GTAG 4044

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1078  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1137

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1138  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1197

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1198  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1257

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1258  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1315

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1316  LRDVALRCLELQPQDRPPSRELLKHPV  1342

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Kinase; Metal-binding; Nucleotide-binding; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013