EKS-CAJ-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.3	7.9E-167	389	665	277

Status

Unreviewed

Ensembl Protein

ENSCJAP00000003322

UniProt Accession

F7FB69;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000002394	ENSCJAP00000002573	ENSCJAT00000002718
ENSCJAG00000002394	ENSCJAP00000047061	ENSCJAT00000057061
ENSCJAG00000002394	ENSCJAP00000003312	ENSCJAT00000003495
ENSCJAG00000002394	ENSCJAP00000003322	ENSCJAT00000003505
ENSCJAG00000002394	ENSCJAP00000004494	ENSCJAT00000004736
ENSCJAG00000002394	ENSCJAP00000043850	ENSCJAT00000052245
ENSCJAG00000002394	ENSCJAP00000004423	ENSCJAT00000004659
ENSCJAG00000002394	ENSCJAP00000048076	ENSCJAT00000053413
ENSCJAG00000002394	ENSCJAP00000004489	ENSCJAT00000004731
ENSCJAG00000002394	ENSCJAP00000017921	ENSCJAT00000018947

Organism

Callithrix jacchus

Functional Description

Protein Length

733

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNRM 60

PVAPYWTSPE KMEKKLHAVP AAKTVKFKCP SSGTPNPTLR WLKNGKEFKP DHRIGGYKVR 120

YATWSIIMDS VVPSDKGNYT CIVENEYGSI NHTYQLDVVE RSPHRPILQA GLPANKTVAL 180

GSNVEFMCKV YSDPQPHIQW LKHIEVNGSK IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR 240

NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC 300

MVGSVIIYKM KSSTKKSDFH SQMAVHKLAK SIPLRRQVTV SADSSASMNS GVLLVRPSRL 360

SSSGTPMLAG VSEYELPEDP RWELPRDRLV LGKPLGEGCF GQVVLAEAIG LDKDKPSRVT 420

KVAVKMLKSD ATEKDLSDLI SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 480

REYLQARRPP GLEYCYNPSH NPEEQLSSKD LVSCAYQVAR GMEYLASKKC IHRDLAARNV 540

LVTEDNVMKI ADFGLARDIH HIDYYKKTTN GRLPVKWMAP EALFDRIYTH QSDVWSFGVL 600

LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM DKPSNCTNEL YMMMRDCWHA VPSQRPTFKQ 660

LVEDLDRIVA LTSNQEYLDL SMPLDQYSPS FPDTRSSTCS SGEDSVFSHE PLPEEPCLPR 720

HPAQLANGGL KRR 733

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACT 60

GCTAGGCCGG CCCCGACCTT GCCTGAACAA GATGCTCTCC CCTCCTCGGA GGATGATGAT 120

GATGATGATG ACTCCTCTTC AGAGGAGAAA GAGACAGATA ACACCAAACC AAACCGTATG 180

CCTGTAGCTC CATATTGGAC ATCCCCAGAA AAGATGGAAA AGAAATTGCA TGCGGTGCCA 240

GCTGCCAAGA CAGTGAAGTT CAAATGCCCT TCCAGTGGGA CCCCAAACCC CACACTGCGC 300

TGGTTGAAAA ATGGCAAAGA ATTCAAACCT GATCACAGGA TTGGAGGCTA CAAGGTCCGT 360

TATGCCACCT GGAGCATCAT AATGGACTCC GTGGTGCCCT CTGACAAGGG CAACTACACC 420

TGCATCGTGG AGAATGAGTA CGGCAGCATC AACCACACCT ACCAGCTTGA TGTCGTGGAG 480

CGGTCCCCTC ACCGGCCCAT CCTGCAAGCA GGGTTGCCCG CCAACAAGAC AGTGGCCCTG 540

GGTAGCAACG TGGAGTTCAT GTGTAAGGTG TACAGTGACC CACAACCACA CATCCAGTGG 600

CTAAAGCACA TCGAGGTGAA CGGGAGCAAG ATTGGTCCAG ACAACCTGCC TTATGTCCAG 660

ATCTTGAAGA CTGCTGGAGT GAATACCACC GACAAAGAGA TGGAGGTGCT TCACTTAAGA 720

AATGTCTCCT TTGAGGACGC AGGGGAGTAT ACGTGCTTGG CGGGTAACTC TATCGGACTC 780

TCCCATCACT CTGCATGGTT GACCGTTCTG GAAGCCCTGG AAGAGAGGCC AGCCGTGATG 840

ACCTCACCCT TGTACCTGGA GATCATCATC TATTGCACAG GGGCCTTCCT CATCTCCTGC 900

ATGGTGGGGT CGGTCATCAT CTACAAGATG AAGAGCAGCA CCAAGAAGAG TGACTTCCAC 960

AGCCAGATGG CCGTGCACAA GCTGGCCAAG AGCATCCCTC TGCGCAGACA GGTAACAGTG 1020

TCCGCTGACT CCAGTGCGTC CATGAACTCT GGGGTTCTTC TGGTTCGGCC ATCACGGCTC 1080

TCCTCCAGTG GGACTCCCAT GCTAGCAGGG GTCTCTGAGT ATGAGCTTCC CGAAGACCCT 1140

CGCTGGGAGC TGCCTCGGGA CAGACTGGTC TTAGGAAAAC CCCTGGGAGA GGGCTGCTTT 1200

GGGCAGGTGG TATTGGCAGA GGCCATCGGA CTGGACAAGG ACAAACCCAG CCGTGTGACC 1260

AAGGTGGCTG TGAAGATGTT GAAGTCGGAT GCAACAGAGA AAGACTTGTC AGACCTGATC 1320

TCAGAAATGG AGATGATGAA GATGATCGGG AAGCATAAGA ACATCATCAA CCTACTGGGG 1380

GCCTGCACGC AGGATGGTCC CTTGTATGTC ATCGTGGAGT ATGCCTCCAA AGGCAACCTG 1440

CGGGAGTACC TGCAGGCCCG GAGGCCCCCG GGGCTGGAAT ACTGCTACAA CCCCAGCCAC 1500

AACCCAGAGG AGCAGCTCTC CTCCAAGGAC CTGGTGTCCT GCGCCTATCA GGTGGCCCGA 1560

GGCATGGAGT ATCTGGCCTC CAAGAAGTGC ATACACCGAG ACCTGGCCGC CAGGAACGTC 1620

CTGGTGACAG AGGACAACGT GATGAAGATT GCAGACTTCG GCCTCGCACG GGACATTCAC 1680

CACATCGACT ACTATAAAAA GACAACCAAC GGCCGACTGC CTGTGAAGTG GATGGCACCC 1740

GAGGCATTGT TTGACCGGAT CTACACCCAC CAGAGTGATG TGTGGTCTTT TGGGGTGCTC 1800

CTGTGGGAGA TCTTCACTCT GGGCGGCTCC CCATACCCCG GTGTGCCTGT GGAGGAGCTT 1860

TTCAAGCTGC TGAAGGAGGG TCACCGCATG GACAAGCCCA GTAACTGCAC CAACGAGCTG 1920

TACATGATGA TGCGGGACTG CTGGCATGCA GTGCCCTCGC AGAGACCCAC CTTCAAGCAG 1980

CTGGTGGAAG ATCTGGACCG CATAGTGGCC TTGACCTCCA ACCAGGAATA CCTGGACCTG 2040

TCCATGCCCC TGGACCAGTA CTCCCCCAGC TTTCCTGACA CCCGGAGCTC TACGTGCTCC 2100

TCAGGGGAGG ATTCCGTCTT TTCTCATGAG CCGCTGCCTG AGGAGCCCTG CCTGCCCCGA 2160

CACCCAGCCC AGCTTGCCAA TGGCGGACTC AAACGCCGCT GA 2202

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 389   LVLGKPLGEGCFGQVVLAEAIGLDKDKPSRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  448

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 449   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  508

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 509   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  568

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 569   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  628

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 629   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  665

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPSR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013