EKS-CAJ-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.1	4.0E-134	150	470	321

Status

Unreviewed

Ensembl Protein

ENSCJAP00000004750

UniProt Accession

F7BM65;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000002609	ENSCJAP00000004748	ENSCJAT00000005009
ENSCJAG00000002609	ENSCJAP00000004750	ENSCJAT00000005011

Organism

Callithrix jacchus

Functional Description

Protein Length

754

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQR RMPQTFRDPA TAPLRKLSVD LIKTYKHINE VYYAKKKRRH QQGQGDDSSH 120

KKERKVYNDG YDDDNYDYIV KNGEKWMDRY EIDSLIGKGS FGQVVKAYDR VEQEWVAIKI 180

IKNKKAFLNQ AQIEVRLLEL MNKHDTEMKY YIVHLKRHFM FRNHLCLVFE MLSYNLYDLL 240

RNTNFRGVSL NLTRKFAQQM CTALLFLATP ELSIIHCDLK PENILLCNPK RSAIKIVDFG 300

SSCQLGQRIY QYIQSRFYRS PEVLLGMPYD LAIDMWSLGC ILVEMHTGEP LFSGANEVDQ 360

MNKIVEVLGI PPAHILDQAP KARKFFEKLP DGSWNLKKTK DGKREYKPPG SRKLHNILGV 420

ETGGPGGRRA GESGHTVADY LKFKDLILRM LDYDPKTRIQ PYYALQHSFF KKTADEGTNT 480

SNSVSTSPAM EQSQSSGTTS STSSSSGGSS GTSNSGRARS DPTHQHRHSG GHFTAAVQAM 540

DCETHSPQVR QQFPAPLGWS GTEAPTQVTV ETHPVQETTF HVAPQQNALH HHHGNSSHHH 600

HHHHHHHHHH GQQALGNRTR PRVYNSPTNS SSTQDSMEVG HSHHSMTSLS SSTTSSSTSS 660

SSTGNQGNQA YQNRPVAANT LDFGQNGAMD VNLTVYSNPR QETGIAGHPT YQFSANTGPA 720

HYMTEGHLTM RQGADREESP MTGVCVQQSP VASS 754

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC GTATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGAGG CGGATGCCCC AAACCTTCCG TGACCCAGCA 240

ACTGCTCCCC TGAGAAAACT CTCTGTTGAC TTGATCAAAA CATACAAGCA TATTAATGAG 300

GTTTACTATG CAAAAAAGAA GCGAAGACAC CAACAGGGCC AGGGAGACGA TTCTAGTCAT 360

AAGAAGGAAC GGAAGGTCTA CAATGATGGT TATGATGATG ATAACTATGA TTATATTGTA 420

AAAAACGGAG AAAAGTGGAT GGATCGTTAC GAAATTGACT CCTTGATAGG CAAAGGTTCC 480

TTTGGTCAGG TTGTAAAGGC ATATGATCGT GTGGAGCAAG AATGGGTTGC CATTAAAATA 540

ATAAAGAACA AGAAGGCTTT TCTGAATCAA GCCCAGATAG AAGTGCGACT TCTTGAGCTC 600

ATGAACAAAC ATGACACTGA AATGAAATAC TACATAGTGC ATTTGAAACG CCACTTTATG 660

TTTCGAAACC ATCTCTGTTT AGTTTTTGAA ATGCTGTCCT ACAACCTCTA TGATTTGTTG 720

AGAAACACCA ATTTCCGAGG GGTCTCTTTG AATCTAACAC GAAAGTTTGC GCAGCAGATG 780

TGCACTGCAC TGCTTTTCCT TGCGACTCCA GAACTTAGTA TCATTCACTG TGACCTAAAA 840

CCTGAAAATA TCCTTCTTTG TAACCCCAAA CGCAGTGCAA TCAAGATCGT TGACTTTGGC 900

AGTTCTTGTC AATTGGGGCA GAGGATATAC CAGTATATTC AGAGTCGCTT TTACCGGTCT 960

CCAGAGGTGC TACTGGGAAT GCCTTATGAC CTTGCCATTG ACATGTGGTC CCTCGGGTGT 1020

ATTTTGGTTG AAATGCACAC TGGAGAACCT CTGTTCAGTG GTGCCAATGA GGTAGATCAG 1080

ATGAATAAAA TAGTGGAAGT TCTGGGTATT CCACCTGCTC ATATTCTCGA CCAAGCACCA 1140

AAAGCAAGAA AGTTCTTTGA GAAGTTGCCA GATGGCTCTT GGAACTTAAA GAAGACCAAA 1200

GATGGAAAAC GGGAGTACAA ACCACCAGGA TCCCGTAAAC TTCATAATAT TCTTGGAGTA 1260

GAAACAGGAG GACCTGGTGG GCGGCGTGCT GGGGAGTCAG GTCATACGGT CGCTGACTAC 1320

TTGAAGTTCA AAGACCTCAT TTTAAGGATG CTTGATTATG ACCCCAAAAC ACGAATTCAA 1380

CCTTACTATG CTCTGCAGCA CAGTTTCTTC AAGAAAACAG CTGACGAAGG TACAAATACA 1440

AGTAATAGTG TGTCTACAAG TCCCGCCATG GAGCAGTCCC AGTCTTCGGG CACCACCTCC 1500

AGCACATCGT CAAGCTCAGG TGGCTCATCG GGGACGAGCA ACAGTGGGAG AGCCCGGTCA 1560

GATCCGACGC ACCAGCATCG GCACAGCGGC GGGCACTTCA CAGCTGCTGT GCAGGCCATG 1620

GACTGCGAGA CACACAGTCC CCAGGTGCGT CAGCAATTTC CTGCTCCTCT TGGTTGGTCA 1680

GGCACTGAAG CTCCTACACA GGTCACTGTT GAAACTCATC CTGTTCAAGA AACCACCTTT 1740

CATGTAGCCC CTCAACAGAA TGCATTGCAT CATCACCATG GAAACAGTTC CCATCACCAT 1800

CACCACCACC ACCACCATCA CCACCACCAT GGACAACAAG CCTTGGGTAA CCGGACCAGG 1860

CCAAGGGTCT ACAATTCTCC AACGAATAGC TCCTCTACCC AAGATTCTAT GGAGGTTGGC 1920

CACAGTCACC ACTCCATGAC ATCCCTGTCT TCCTCAACGA CTTCTTCCTC GACATCTTCC 1980

TCCTCTACTG GTAATCAAGG CAATCAGGCC TACCAGAATC GCCCAGTGGC TGCTAATACC 2040

TTGGACTTTG GACAAAATGG AGCTATGGAC GTTAATTTGA CCGTCTACTC CAATCCCCGC 2100

CAAGAGACTG GCATAGCTGG ACATCCAACA TACCAGTTTT CTGCTAATAC AGGTCCTGCA 2160

CATTACATGA CTGAAGGACA TCTGACAATG AGGCAAGGGG CTGATAGAGA AGAGTCCCCC 2220

ATGACAGGAG TTTGTGTGCA ACAGAGTCCT GTAGCTAGCT CGTGA 2265

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 150   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  209

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 210   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  269

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 270   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  328

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 329   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  388

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           +  + lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 389   LPDGSWNLKKTkdgkreykpPGSRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  443

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 444   KDLILRMLDYDPKTRIQPYYALQHSFF  470

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGSWNLKKT KDGKREYKPP GSRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013