EKS-CAJ-00463

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00463

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	507.2	2.3E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSCJAP00000006032

UniProt Accession

F7H1U6;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000003293	ENSCJAP00000006032	ENSCJAT00000006365

Organism

Callithrix jacchus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIVHNLCGH 360

DVPEKAEGEP KENGLVILVS VITSCLQTLK FCDSKLAAKE FIIHLAPRLS VEILLDSITP 420

YILHISNDTV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALYALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHRISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLIKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPN MPQALPKGSD QEAIQTGKPP RSESSAGICV 900

PLSTSPQVPE VTTVQNKKPV IPVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 1080

KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AACTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTGGA GAGTTATTTT 60

TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 120

GCTCGAGCCA AGCATCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACTAGCTA TAAACAAGAA CTGGAGGAAC TGAAAATCAG GCTTAATTCT 240

GCACAGAATT GTCTGCCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 300

CTTTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 360

AATAACATTG AGAAGCGCTG GATCGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 420

AAGTCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 480

TGGGTTCTTC TAACAGATTT TGCCAGTTTT AAACCCACTT ATCTTCCAGA AGACAACCCA 540

GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 600

CGGTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAGT ATATGAGAGA TCCTTCAACT 660

CCACTTGTAG ACTTAAATAG CAATCAGAGA ACCAGAGGCG AGTTGAAGAG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTCCC ATTATTTGAT 780

CTCTCTCAAC TTTTGGCTTA TAGAAATGGG CATTTTTTCC CTGAACAAGT GCTAAACAAA 840

ATTGAAGATC GCAGCATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGAGG CAGAAGATTA CTTAAAGCAG CAGCGTGGCA ATGCTTTTCC TGAAATATTT 960

TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAATATTG TTCACAACCT CTGTGGACAT 1080

GATGTGCCAG AAAAAGCTGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 1140

GTTATAACAT CCTGCTTACA GACGCTTAAA TTCTGTGATT CCAAACTAGC TGCAAAGGAA 1200

TTTATTATTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATAG TATTACTCCA 1260

TATATTTTGC ATATTAGCAA TGACACTGTT CCTAGAGTGA GAGCTGAAGC TTTGAGGACA 1320

TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGCA ATGATATCAA TATTTATCCG 1380

GAATATATTC TGCCAGGCAT AGCTCACTTG GCCCAAGATG ATGCTACTAT CGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTTCT GGAATTAGTA 1500

CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAAGTTACA 1560

CATCCAAATG GAAATTATGA CACAGAGCTT CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 1620

GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCTTAAT GGAAAATGGA 1680

ATAACACGGC TATGTGTATT CTTTGGACGT CAGAAAGCCA ATGATGTTTT GTTGTCCCAC 1740

ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTTAA GCCCCTGCTG 1860

CAACAAGGCC TTAGTGATGC TGAGGAATTT GTTATTGTGA AAGCTCTTTA TGCCCTTACT 1920

TGTATGTGCC AGTTAGGATT GCTGCAAAAA CCCCATGTTT ATGAATTTGC CAGTGATATT 1980

GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGCTATG GTGCTGTGGG ATTTATCACA 2040

GTGGTAGCTC ATCGAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 2100

CCATACATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTTCT CAGTGTTTTA 2160

AAGGAACCAG TAAGCCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 2220

TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GGTCTCTTCC TGACTGCCCT 2280

CCACCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAAC TGCTCTCACA GGGAATGACA 2340

GAGGAAGAGG AAGACAAGCT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 2400

AAGGCGAATA TAGTGGATCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 2460

TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTCA TTAAAACCAA ACAAGAACCA 2520

GATGACAAAC GTGCTAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GGTCACTGGA ACCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAC 2640

CAGGAGGCGA TTCAGACTGG GAAGCCTCCT CGTTCTGAGT CTTCTGCTGG CATTTGTGTC 2700

CCTTTGTCAA CTTCTCCACA GGTTCCAGAA GTAACAACTG TCCAAAATAA GAAACCAGTA 2760

ATACCAGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGGAT TACAACTTGT 2820

AAAACTGAAC TTCAGCAACT TATTCAACAG AAGCGGGAGC AGTGCAATGC TGAGAGAATA 2880

GCCAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC AGGATGGCGT 2940

CCTAAAGGAC TATTAGTTGC CCATCTGCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATTTGG 3060

AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATATAGCCGA 3120

ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 3180

TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTACC CAAGTCTCCT 3240

AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 3300

ATGCATCACT TCAACTCTGG GGCGCAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 3360

CTGGTTGGCT GGGATCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 3420

TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATTCACCAAT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 3540

CATCCTTCCA GGGCTCGAAT CAGGCGCCTC TCGATGCACC CTCTGTATCA GTCCTGGGTG 3600

ATTGCAGCTG TTCAGGGCAA CAATGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 3660

AGATTCACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 3720

AGTGTTCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTGCT AACAGCTGGC 3780

TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 3840

GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 3900

GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 3960

CCAGAGTCCC TGCCCGTGGG ACATCACGAC ATCATCACTG ATGTTGCCAC ATTCCAGACA 4020

ACACAGGGCT TCATTGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKASEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         ++++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GMFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGHFFPEQVLNKIEDRSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLNSAQNCL 60

PFQKASEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GMFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGHFFPE QVLNKIEDRS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013