EKS-CAJ-00445

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00445

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	487.8	1.7E-146	76	344	269

Status

Unreviewed

Ensembl Protein

ENSCJAP00000006096

UniProt Accession

F7FY28;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100391859

Gene Synonyms/Alias

LOC100391859;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000003298	ENSCJAP00000006096	ENSCJAT00000006434
ENSCJAG00000003298	ENSCJAP00000006104	ENSCJAT00000006442

Organism

Callithrix jacchus

Functional Description

Protein Length

1712

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK YVAEFLEWAK 60

PFTQLVKEMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC 120

FREERDVLVN GDCQWITALH YAFQDENHLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY 180

IGEMVLAIDS IHQLHYVHSN RDIKPDNVLL DVNGHIRLAD FGSCLKMNDD GTVQSSVAVG 240

TPDYISPEIL QAMEDGMGKY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHEE 300

RFQFPSHVTD VSEEAKDLIQ RLICSRERRL GQNGIEDFKK HAFFEGLNWE NIRNLEAPYI 360

PDVSSPSDTS NFDVDDDVLR NTEILPPGSH TGFSGLHLPF IGFTFTTESC FSDRGSLKSI 420

MQSNTLTKDE DVQRDLEHSL QMEAYERRIR RLEQEKLELS RKLQESTQTV QSLHGSSRAL 480

GNSNRDKEIK KLNEEIERLK NKIAVNQNKL ERQLEDTVAL CHEREDSGQR LRGLENTAWS 540

GRRREELHKQ LVEASERLKS QAKELRDAHQ QRKLALQEFS ELNERMAELR SQKQKVSRQL 600

RDKEEEMEVA MQKVDTMRQE MRRSEKLRKE LEAQLDDAVA QASKERKLRE HSENFSKQME 660

SELEALKMKQ GGRGPGATSE HQQEISKIKS ELEKKVLFYE EELVRREASH VLEVKNVKKE 720

VHDSESHQLA LQKEILMLKD KLEKSKRERR NEVEEAVGTV KDKYERERAM LFDENKKVTA 780

ENEKLCSFVD KLTAQNRQLE DELQDLAAKK ESVAHWEAQI AEIIQWVSDE KDARGYLQAL 840

ASKMTEELEA LRSSSLGSRT LDPLWKVRRS QKLDMSARLE LQSALEAEIR AKQLVQEELR 900

KVKDANLTLE SKLKDSEAKN RELLEEMEIL KKKMEEKFRA DTGKLMSCDS ALFEYNFNTA 960

PLAHDLTFRT SSASEQEAQA PKPEASPLIS AAASEQQEDM ARPPQRPSAV PLPTTQALAL 1020

AGPKPKAHQF SIKSFSSPTQ CSHCTSLMVG LIRQGYACEV CSFACHVSCK DSAPQVCPIP 1080

PEQSKRPLGV DVQRGIGTAY KGHVKVPKPT GVKKGWQRAY AVVCDCKLFL YDLPEGKSTQ 1140

PGVIASQVLD LRDEEFSVSS VLASDVIHAT RRDIPCIFRV TASLLGAPSK TSSLLILTEN 1200

ENEKRKWVGI LEGLQSILHK NRLRNQVVHV PLEAYDSSLP LIKAVLTAAI VDADRIAVGL 1260

EEGLYVIEVT RDVIVRAADC KKVHQIELAP REKIVILLCG RNHHVHLYPW SSLDGAEGSF 1320

DIKLPETKGC QLMATATLKK SSATCLFVAV KRLILCYEIQ RTKPFHRKFN EIVAPGSVQC 1380

LAMLRDRLCV GYPSGFCLLS IQGDGQPLNL VNPNDPSLAF LSQQSFDALC AVELESEEYL 1440

LCFSHGLYVD PQGRRARAQE LMWHAAPVAS SIAPTHVTVY SEYGVDVFDV RTMEWVQTIG 1500

LRRIRPLNSE GTLNLLSCEP PRLIYFKSKF SGAVFNVPDT CDNSKKQMLR TRSKRRFVFK 1560

VPEEERLQQR REMLRDPELR SKMISNPTNF NHVAHMGPGD GMQVLMDLPL SAGPPSQEER 1620

PGPVPASLAR QPPSRNKPYI SWPSSGGSEP GVAVPLRSMS DPDQDFDKEP DSDSTKHSTP 1680

SNSSNPSGPP SPNSPHRSQL PLEGLEQPAC DA 1712

Nucleotide Sequence
(FASTA)

ATGTCGGCCA AGGTGCGGCT CAAGAAGCTG GAGCAGCTGC TCCTGGACGG GCCCTGGCGC 60

AACGAGAGCG CCCTGAGCGT GGAGACGCTG CTGGACGTGC TCGTCTGCCT GTACACCGAG 120

TGCAGCCACT CGGCCCTGCG CCGCGACAAG TACGTGGCCG AGTTCCTGGA GTGGGCTAAA 180

CCATTTACAC AGCTGGTGAA AGAAATGCAG CTTCATCGAG AAGACTTTGA AATAATTAAA 240

GTAATTGGAA GAGGAGCTTT CGGTGAGGTT GCTGTTGTCA AAATGAAGAA CACTGAACGA 300

ATTTATGCGA TGAAAATCCT CAACAAGTGG GAAATGCTGA AAAGAGCAGA GACCGCGTGC 360

TTCCGAGAGG AGCGCGACGT GCTGGTGAAC GGCGACTGCC AGTGGATCAC CGCGCTGCAC 420

TACGCCTTTC AGGACGAGAA CCACCTGTAC TTAGTCATGG ATTACTACGT GGGTGGTGAT 480

TTACTGACCC TGCTCAGCAA ATTTGAAGAC AAGCTTCCAG AAGACATGGC GAGGTTCTAC 540

ATTGGTGAAA TGGTGCTGGC CATTGACTCC ATCCATCAGC TTCATTACGT GCACAGTAAC 600

AGAGACATTA AACCTGACAA TGTCCTTTTG GACGTGAATG GTCATATCCG CCTGGCTGAC 660

TTTGGATCAT GTTTGAAGAT GAATGATGAT GGAACTGTGC AGTCCTCTGT GGCCGTGGGC 720

ACACCTGACT ACATCTCACC AGAGATCCTG CAGGCAATGG AGGACGGCAT GGGCAAGTAC 780

GGGCCCGAGT GTGACTGGTG GTCCCTCGGA GTCTGCATGT ATGAGATGCT CTACGGAGAA 840

ACGCCGTTTT ATGCAGAGTC ACTCGTGGAG ACCTACGGGA AGATCATGAA CCATGAAGAG 900

CGATTCCAGT TCCCGTCCCA CGTCACAGAT GTATCTGAAG AAGCCAAGGA CCTCATCCAG 960

AGGCTCATCT GCAGCAGAGA GCGCCGGCTG GGGCAGAATG GAATAGAGGA TTTCAAAAAG 1020

CACGCGTTTT TTGAAGGTCT AAACTGGGAA AATATACGCA ACCTAGAAGC ACCTTATATT 1080

CCCGACGTGA GCAGCCCCTC GGACACATCC AACTTTGACG TGGACGACGA CGTGCTGAGA 1140

AACACGGAAA TATTACCTCC TGGTTCTCAC ACAGGCTTTT CTGGATTACA TTTGCCATTC 1200

ATTGGTTTTA CATTCACAAC GGAAAGCTGT TTTTCCGATC GAGGCTCTCT GAAGAGCATA 1260

ATGCAGTCCA ACACATTAAC CAAAGATGAG GACGTGCAGC GGGACCTGGA GCACAGCCTG 1320

CAGATGGAGG CTTACGAGAG GAGGATCCGG AGGCTGGAGC AGGAGAAGCT GGAGCTCAGC 1380

AGGAAGTTGC AAGAGTCCAC CCAGACGGTG CAGTCCCTCC ACGGCTCATC TCGGGCCCTC 1440

GGCAATTCAA ACCGAGATAA AGAAATCAAA AAGCTAAATG AAGAGATCGA ACGCTTGAAG 1500

AATAAAATAG CAGTAAATCA AAACAAGCTC GAGCGACAAC TTGAGGACAC CGTGGCGCTT 1560

TGCCATGAGC GTGAGGACTC CGGGCAGCGA CTCCGGGGGC TGGAGAACAC TGCATGGTCC 1620

GGCAGGAGAA GGGAGGAGTT GCACAAGCAA CTTGTTGAAG CCTCGGAGAG GTTGAAATCC 1680

CAGGCCAAAG AACTCAGAGA TGCCCATCAG CAGCGAAAGC TGGCCCTGCA GGAGTTTTCG 1740

GAGCTGAACG AGCGCATGGC TGAGCTCCGC TCCCAGAAGC AGAAGGTGTC GCGGCAGCTG 1800

CGGGACAAGG AGGAGGAGAT GGAGGTGGCC ATGCAGAAGG TGGACACAAT GCGGCAGGAG 1860

ATGCGGAGGT CCGAGAAGCT CAGGAAAGAG TTGGAAGCTC AGCTGGACGA TGCTGTTGCC 1920

CAGGCCTCCA AGGAGCGTAA GCTTCGCGAG CACAGTGAGA ACTTCTCCAA GCAAATGGAA 1980

AGCGAGCTGG AGGCCCTCAA GATGAAGCAA GGCGGCCGGG GACCAGGTGC CACTTCAGAG 2040

CACCAGCAAG AGATTTCCAA AATAAAATCC GAGCTGGAGA AGAAAGTTTT ATTTTATGAA 2100

GAGGAATTGG TCAGACGTGA GGCCTCCCAT GTGCTAGAAG TGAAAAATGT GAAGAAGGAG 2160

GTGCATGATT CAGAAAGCCA CCAGCTGGCC CTGCAGAAAG AAATCTTGAT GCTAAAAGAT 2220

AAGTTAGAAA AGTCGAAACG AGAACGGCGT AACGAGGTGG AGGAGGCGGT AGGCACAGTA 2280

AAAGATAAGT ACGAACGAGA GCGAGCGATG CTGTTTGATG AGAACAAGAA GGTGACCGCG 2340

GAAAACGAGA AGCTCTGTTC CTTTGTGGAT AAACTCACAG CTCAAAATAG ACAGCTGGAG 2400

GATGAGCTGC AGGATCTGGC AGCCAAGAAG GAGTCGGTGG CCCACTGGGA AGCTCAGATT 2460

GCGGAAATCA TCCAGTGGGT CAGCGACGAG AAAGATGCCC GGGGCTACCT TCAAGCTCTT 2520

GCTTCCAAGA TGACCGAAGA GCTCGAGGCT TTGAGGAGTT CTAGTCTGGG GTCAAGAACA 2580

CTGGATCCGC TGTGGAAGGT GCGCCGCAGC CAGAAGCTGG ACATGTCCGC GAGGCTGGAG 2640

CTGCAGTCGG CCCTGGAAGC AGAGATCCGG GCCAAGCAGC TTGTCCAGGA GGAGCTGAGG 2700

AAGGTCAAGG ATGCCAACCT CACCTTGGAA AGTAAACTAA AGGATTCCGA AGCCAAAAAC 2760

AGAGAATTAT TAGAAGAAAT GGAAATTTTG AAGAAAAAGA TGGAAGAAAA ATTCAGAGCA 2820

GATACTGGTA AATTAATGTC ATGTGATTCT GCATTATTTG AATATAATTT CAACACCGCT 2880

CCTCTTGCAC ATGACCTGAC ATTTAGAACC AGCTCAGCTA GTGAACAAGA AGCACAAGCT 2940

CCGAAGCCAG AAGCGTCCCC GTTGATATCT GCAGCTGCAT CAGAGCAGCA GGAGGACATG 3000

GCTCGGCCCC CGCAGAGGCC ATCCGCTGTG CCGTTGCCCA CCACGCAGGC CCTGGCTCTG 3060

GCTGGACCGA AGCCAAAAGC TCACCAGTTC AGCATCAAGT CCTTCTCCAG CCCTACTCAG 3120

TGCAGCCACT GCACCTCCCT GATGGTCGGG CTGATCCGGC AGGGCTACGC TTGTGAGGTG 3180

TGTTCCTTCG CTTGCCATGT GTCCTGCAAA GACAGTGCCC CCCAGGTGTG CCCAATACCT 3240

CCTGAGCAGT CCAAGAGGCC TCTGGGTGTG GATGTGCAGC GAGGCATAGG AACAGCTTAC 3300

AAAGGCCACG TCAAGGTCCC AAAGCCCACT GGGGTGAAGA AGGGATGGCA GCGCGCATAT 3360

GCGGTTGTCT GTGACTGCAA GCTCTTCCTT TATGATCTGC CTGAAGGAAA GTCCACCCAG 3420

CCTGGTGTCA TTGCGAGTCA GGTCTTAGAT CTCAGAGATG AAGAGTTTTC CGTGAGCTCG 3480

GTCCTGGCCT CAGATGTCAT TCATGCTACC CGTCGAGACA TTCCGTGTAT ATTCAGGGTG 3540

ACGGCCTCTC TCTTAGGTGC ACCTTCTAAG ACCAGCTCGC TGCTCATTCT GACAGAAAAT 3600

GAGAACGAAA AGAGGAAGTG GGTTGGGATT CTAGAAGGAC TCCAGTCCAT CCTTCATAAA 3660

AACCGGCTGA GGAACCAGGT CGTGCATGTT CCCTTGGAAG CCTACGACAG CTCGCTGCCT 3720

CTCATCAAGG CCGTCTTGAC AGCTGCCATC GTGGACGCGG ACAGGATTGC GGTCGGCTTA 3780

GAAGAAGGGC TGTATGTCAT CGAGGTCACC CGAGATGTGA TCGTCCGAGC AGCTGACTGT 3840

AAGAAGGTAC ACCAGATTGA GCTTGCTCCC AGAGAGAAGA TCGTAATCCT TCTGTGTGGC 3900

CGGAACCACC ACGTGCACCT CTATCCGTGG TCATCCCTCG ACGGAGCAGA AGGCAGCTTT 3960

GACATCAAGC TTCCGGAAAC GAAAGGCTGC CAGCTCATGG CCACAGCGAC GCTGAAGAAG 4020

AGCTCTGCCA CCTGCCTGTT TGTAGCCGTG AAACGGCTGA TCCTTTGCTA TGAGATCCAG 4080

AGAACTAAGC CATTCCACAG AAAGTTCAAT GAGATTGTGG CTCCCGGCAG CGTGCAGTGC 4140

CTGGCGATGC TCAGGGACAG GCTCTGTGTG GGCTACCCTT CTGGGTTCTG CCTGCTGAGC 4200

ATCCAGGGGG ACGGGCAGCC TCTAAACCTG GTAAATCCCA ATGACCCCTC GCTTGCGTTC 4260

CTCTCACAAC AGTCTTTTGA TGCCCTTTGT GCTGTGGAGC TCGAAAGCGA GGAGTACCTG 4320

CTTTGCTTCA GCCACGGACT GTACGTGGAC CCGCAAGGCC GGAGGGCACG CGCGCAGGAG 4380

CTCATGTGGC ATGCGGCTCC AGTCGCCAGT AGTATAGCCC CCACCCATGT CACGGTGTAC 4440

AGCGAGTACG GCGTGGACGT CTTCGATGTG CGCACCATGG AGTGGGTGCA GACCATAGGC 4500

CTGCGCAGGA TAAGGCCCCT GAATTCTGAA GGCACCCTCA ACCTCCTCAG CTGTGAGCCT 4560

CCACGCCTGA TCTACTTCAA GAGCAAGTTC TCGGGAGCGG TTTTCAACGT GCCAGACACC 4620

TGCGACAACA GCAAGAAGCA GATGCTGCGC ACCAGGAGCA AAAGGCGGTT CGTCTTCAAA 4680

GTCCCGGAGG AGGAGAGACT GCAGCAGCGG CGAGAGATGC TTAGAGACCC AGAATTGAGA 4740

TCCAAAATGA TATCCAACCC AACCAACTTC AACCACGTGG CCCACATGGG CCCGGGCGAC 4800

GGCATGCAGG TGCTCATGGA CCTGCCTCTG AGTGCCGGGC CCCCCTCTCA GGAGGAAAGG 4860

CCAGGCCCCG TGCCTGCCAG CCTGGCCCGC CAGCCTCCGT CCAGGAACAA GCCCTACATC 4920

TCGTGGCCCT CGTCAGGTGG ATCGGAGCCG GGCGTGGCTG TGCCTCTGAG AAGTATGTCC 4980

GATCCAGACC AGGACTTTGA CAAAGAGCCG GATTCGGACT CCACCAAACA CTCAACTCCA 5040

TCGAACAGCT CCAACCCCAG CGGTCCACCG AGCCCTAACT CCCCCCACAG GAGCCAGCTC 5100

CCCCTGGAAG GCCTGGAGCA GCCAGCCTGT GACGCCTGA 5139

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde++lylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 136   ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  195

         ************************************************************

S: 121   yvh..rdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         yvh  rdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+

Q: 196   YVHsnRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED  255

         ***999******************************************************

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseea

Q: 256   GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEA  315

         ****************************************************99******

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         kdli++l++sre+rlg++gied+kkh+ff

Q: 316   KDLIQRLICSRERRLGQNGIEDFKKHAFF  344

         ****************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITALHYAFQD ENHLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHSNRDIKP DNVLLDVNGH IRLADFGSCL KMNDDGTVQS SVAVGTPDYI SPEILQAMED 180

GMGKYGPECD WWSLGVCMYE MLYGETPFYA ESLVETYGKI MNHEERFQFP SHVTDVSEEA 240

KDLIQRLICS RERRLGQNGI EDFKKHAFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013