EKS-CAJ-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.3	3.6E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSCJAP00000006251

UniProt Accession

F7GW73;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000003403	ENSCJAP00000044220	ENSCJAT00000061486
ENSCJAG00000003403	ENSCJAP00000006250	ENSCJAT00000006593
ENSCJAG00000003403	ENSCJAP00000006251	ENSCJAT00000006594

Organism

Callithrix jacchus

Functional Description

Protein Length

970

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSIEAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKTKDLGTVE DSIDSGHATI STAITASSST 300

SISGSLFDKR RLLIGQPLPN KMTVFPKNKS SSDFSSSGNG SSFYTQWGNQ ETSNSGRGRV 360

IQNAEERPHS RYLRRAHSSD RSDTSNSQSR AKTYTMERCH SAEMLSKSKR SGGGENEERY 420

SPTNNNANIF NFFKEKTSNN SGSFEKPDNN QALSNHLCPG KTPLPFADLT PQTDTVQQWF 480

GNLQINAHLR KTTEYDSISS NQDFQDHPDL QKDTSKNAWT NIKVKKSSDA SDNAHSVNQP 540

NTMKYMMALH SKPGIIQQEC VFGLDPLSEQ SKTRDVEPPL GYQNRTLRSI TSPLIAHRLK 600

PIRQKTKKAV VSILDSEEVC VELLKEYASQ EYVKEVLQIS SDGNTITIYY PNDGRGLPLA 660

DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTRYA KCILMENSPG 720

ADFEVWFYDG AKIHKTKDFI QVIEKTGKSY TLKSESEVNS LKEEMKMYMD HANEGHHICL 780

ALESIISEEE RKTRSAPFFP IIIGRKPSST SSPKALSPPP SVDSNYPSRD RASFNRMVMN 840

SAASPSQAPM LNSSMITNEG LGLTATASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT 900

QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPEYIKQ KLQCLSSILL 960

MFSNSTPNFH 970

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT CCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCATA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCAGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTTTATAA CTATTTTGAA 240

GATAGCAATT ATGTGTATCT GGTATTAGAA ATGTGCCATA ATGGGGAAAT GAACAGGTAT 300

CTGAAGAACA GAGTGAAACC CTTCTCAGAA AATGAAGCTC GACATTTCAT GCACCAGATC 360

ATCACAGGGA TGTTGTATCT TCATTCTCAT GGTATACTAC ATCGGGACCT CACACTTTCT 420

AACCTCTTAC TTACTCGTAA TATGAATATC AAGATTGCTG ATTTTGGGCT GGCAACTCAG 480

TTGAAAATGC CACATGAAAA GCACTATACA TTATGTGGAA CTCCTAACTA CATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGCCTT GAATCTGATG TTTGGTCCCT GGGCTGTATG 600

TTTTATACAT TACTTATCGG GAGACCACCC TTTGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGTCAATAGA GGCCAAGGAC 720

CTTATTCACC AATTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTATC TTCAGTATTG 780

GACCATCCTT TTATGTCCCG AAATTCTTCA ACAAAAACTA AAGATTTAGG AACTGTGGAA 840

GACTCAATTG ATAGTGGGCA TGCCACAATT TCTACTGCAA TTACAGCTTC CTCCAGTACC 900

AGTATAAGTG GTAGTTTATT TGACAAAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTG TATTTCCAAA GAATAAAAGT TCAAGTGATT TTTCTTCTTC AGGAAATGGA 1020

AGCAGTTTTT ATACTCAGTG GGGAAATCAA GAAACCAGTA ATAGTGGAAG GGGAAGAGTA 1080

ATTCAAAATG CAGAAGAAAG ACCACATTCT CGATACCTTC GTAGAGCTCA TTCCTCTGAT 1140

AGATCTGACA CTTCTAATAG TCAATCTCGA GCAAAAACAT ATACAATGGA ACGATGTCAC 1200

TCAGCAGAAA TGCTTTCAAA GTCCAAAAGA TCAGGAGGAG GTGAAAATGA AGAGAGATAC 1260

TCGCCCACAA ACAACAATGC CAACATCTTT AACTTCTTTA AAGAGAAGAC ATCCAACAAT 1320

TCTGGATCTT TTGAAAAACC TGATAACAAT CAAGCACTCT CCAATCATCT TTGCCCAGGA 1380

AAAACTCCTC TTCCATTTGC AGACCTGACA CCTCAGACTG ACACAGTACA ACAGTGGTTT 1440

GGGAATCTGC AAATAAATGC TCACTTAAGA AAAACTACTG AATATGACAG CATCAGCTCA 1500

AACCAGGATT TCCAGGACCA TCCAGATTTG CAGAAGGACA CGTCAAAAAA TGCCTGGACT 1560

AATATAAAAG TCAAAAAGAG CTCTGATGCT TCTGATAATG CACATTCTGT AAATCAGCCA 1620

AATACCATGA AATACATGAT GGCACTTCAC AGTAAACCTG GGATAATCCA ACAAGAATGT 1680

GTTTTTGGCT TAGATCCTCT TTCTGAACAG AGCAAGACTA GGGATGTGGA GCCACCATTG 1740

GGTTATCAGA ATCGTACATT AAGAAGCATT ACATCTCCAT TGATTGCTCA CAGGTTAAAA 1800

CCAATCAGAC AGAAAACCAA AAAGGCCGTG GTGAGCATAC TTGATTCAGA GGAGGTGTGT 1860

GTGGAGCTTC TAAAGGAGTA TGCATCTCAA GAATATGTGA AAGAAGTTCT TCAGATATCT 1920

AGTGATGGAA ATACGATCAC TATTTATTAT CCAAATGATG GAAGAGGTTT ACCTCTTGCT 1980

GATAGACCTC CCTCACCTAC TGACAACATC AGTAGGTACA GCTTTGACAA TTTACCAGAA 2040

AAATACTGGC GAAAATATCA ATATGCTTCC AGGTTTGTAC AGCTTGTAAG ATCTAAATCT 2100

CCCAAAATCA CTTATTTTAC AAGATATGCT AAATGCATTT TGATGGAGAA TTCTCCTGGT 2160

GCTGATTTCG AGGTTTGGTT TTATGATGGG GCAAAAATAC ACAAAACAAA AGATTTCATT 2220

CAGGTGATTG AAAAGACAGG GAAGTCTTAT ACTTTAAAAA GTGAAAGTGA AGTTAATAGC 2280

TTGAAAGAAG AGATGAAAAT GTATATGGAT CATGCTAATG AGGGTCATCA TATTTGTTTA 2340

GCACTGGAAT CCATAATTTC AGAAGAGGAA AGGAAAACTA GGAGTGCTCC CTTTTTTCCA 2400

ATAATCATAG GAAGAAAACC TAGTAGTACT AGTTCACCTA AGGCCTTATC ACCTCCTCCT 2460

TCTGTGGATT CAAATTACCC ATCGAGAGAT AGAGCATCTT TCAATAGAAT GGTCATGAAT 2520

AGTGCTGCTT CTCCATCACA GGCACCAATG CTTAATTCCT CTATGATTAC AAATGAAGGA 2580

CTTGGTCTTA CAGCTACAGC TTCTGGAACA GACATCTCTT CTAATAGTCT AAAAGATTGT 2640

CTACCTAAAT CAGCACAACT TTTGAAATCT GTTTTTGTGA AAAATGTTGG TTGGGCTACA 2700

CAGTTAACTA GCGGAGCTGT GTGGGTTCAG TTTAATGATG GGTCCCAGTT GGTTGTGCAG 2760

GCAGGAGTGT CTTCTATCAG TTATACCTCA CCAAATGGTC AAACAACTAG GTATGGAGAA 2820

AATGAAAAAT TACCAGAATA CATCAAACAG AAATTGCAGT GTTTGTCTTC CATCCTTTTG 2880

ATGTTTTCTA ATTCAACTCC TAATTTTCAT TGA 2913

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRvKPFSENEARHFMHQIITGMLYLHSHG  131

         *********************************9**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSIEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEM CHNGEMNRYL KNRVKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSIEAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013