EKS-CAJ-00377

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00377

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	416.3	8.8E-125	163	407	245

Status

Unreviewed

Ensembl Protein

ENSCJAP00000007430

UniProt Accession

F6PHC1;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000004076	ENSCJAP00000051061	ENSCJAT00000053832
ENSCJAG00000004076	ENSCJAP00000007430	ENSCJAT00000007851

Organism

Callithrix jacchus

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

MLKGEKLQVL KGTGAWWLAK SLVTGREGYV PSNFVARVES LEVERWFFRS LNRKEAERQL 60

LAPVNKAGSF LIRESETNKG AFSLSVKDVT AQGELIKHYK IRSLDEGGYY ISPRITFPSL 120

QALVQHYSKK GDGLCQRLTL PCVGLAPQNP WAQDEWEIPR QSLKLVRKLG SGQFGDVWMG 180

YYKKNIKVAI KTLKEGAMSP EAFLGEANVM KTLQHKRLVR LYAVVTKEPI YIVTEYMARG 240

CLLDFLKTDE GSRLSLPRLI DMSAQIAEGM AYIERMNSIH RDLRAANILV SETLCCKIAD 300

FGLARIIDSE YMAQEGAKFP IKWTAPEAIH FGVFTIKADV WSFGVLLMEV VTYGRVPYPG 360

MSNPEVIRNL ERGYRMPRPD TCPPELYRGV IAQCWRSRPE ERPTFDCAPR VTRPLCAAPF 420

V 421

Nucleotide Sequence
(FASTA)

ATGCTGAAGG GGGAGAAGCT ACAGGTCCTG AAGGGAACTG GAGCCTGGTG GCTGGCCAAG 60

TCACTCGTCA CAGGAAGAGA AGGCTATGTG CCCAGCAACT TTGTGGCCCG AGTGGAGAGC 120

CTGGAAGTGG AGAGGTGGTT CTTTAGATCG CTGAACCGGA AGGAGGCTGA GAGGCAGCTT 180

CTGGCTCCAG TCAACAAGGC CGGCTCCTTT CTCATCAGAG AGAGTGAAAC CAACAAAGGT 240

GCCTTCTCCC TGTCTGTGAA GGACGTCACT GCCCAGGGGG AGCTGATCAA GCACTATAAG 300

ATCCGCTCCT TGGATGAGGG GGGCTACTAC ATCTCCCCCC GGATCACCTT CCCCTCACTG 360

CAGGCCCTGG TGCAGCACTA TTCTAAGAAG GGGGATGGTC TCTGCCAGAG GCTGACCCTG 420

CCCTGTGTGG GCCTGGCCCC ACAAAACCCC TGGGCCCAGG ATGAATGGGA AATCCCCCGG 480

CAGTCTCTCA AGCTGGTCAG GAAACTCGGG TCTGGACAAT TTGGCGACGT CTGGATGGGT 540

TACTACAAAA AGAACATAAA GGTGGCCATC AAGACGCTGA AGGAGGGAGC CATGAGTCCG 600

GAAGCCTTCC TGGGCGAGGC CAACGTGATG AAGACCCTGC AGCACAAGCG GCTGGTCCGG 660

CTCTATGCCG TGGTCACCAA GGAGCCCATC TACATTGTCA CCGAGTACAT GGCCAGAGGG 720

TGCCTGCTGG ATTTCTTGAA GACGGATGAA GGGAGCAGAT TGTCACTCCC AAGGCTGATC 780

GACATGTCGG CCCAGATTGC TGAAGGGATG GCGTACATCG AGCGCATGAA TTCCATCCAC 840

CGCGACCTGC GGGCGGCTAA CATCCTGGTG TCTGAGACCT TGTGCTGCAA GATTGCTGAT 900

TTTGGCTTGG CTCGGATCAT CGACAGTGAA TACATGGCCC AGGAGGGGGC CAAGTTCCCC 960

ATCAAGTGGA CTGCCCCAGA AGCCATCCAC TTCGGGGTCT TCACCATCAA AGCTGATGTG 1020

TGGTCATTTG GAGTCCTCCT GATGGAAGTC GTCACTTACG GGCGGGTGCC ATACCCAGGG 1080

ATGAGCAACC CCGAGGTCAT CCGCAACCTG GAGCGCGGTT ACCGCATGCC GCGTCCCGAC 1140

ACCTGCCCGC CCGAGCTGTA CCGCGGCGTC ATCGCCCAGT GCTGGCGCAG CCGGCCGGAG 1200

GAGCGGCCCA CCTTCGACTG TGCGCCCCGA GTTACGCGGC CTCTCTGTGC TGCCCCATTT 1260

GTA 1263

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfG+vw+g++k+++kva+ktlkeg +speafl ea+++k+l+h++lv+ly

Q: 163   LKLVRKLGSGQFGDVWMGYYKKNIKVAIKTLKEGAMSPEAFLGEANVMKTLQHKRLVRLY  222

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+aeGmay+e++n ihr

Q: 223   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHR  281

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+ey+a+egak+PikWtaPeai++g+ftik+dv

Q: 282   DLRAANILVSETLCCKIADFGLARII-DSEYMAQEGAKFPIKWTAPEAIHFGVFTIKADV  340

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfG+ll+e+vt+G+vPypGm+n ev++++ergyr+prp++cp ely+ ++++cw+++pe

Q: 341   WSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRgVIAQCWRSRPE  400

         ************************************************9***********

S: 240   erPtfet  246

         erPtf+

Q: 401   ERPTFDC  407

         *****96

Domain Sequence
(FASTA)

LKLVRKLGSG QFGDVWMGYY KKNIKVAIKT LKEGAMSPEA FLGEANVMKT LQHKRLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDSEYM AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA QCWRSRPEER 240

PTFDC 245

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013