EKS-CAJ-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	508.1	1.4E-152	563	849	287

Status

Unreviewed

Ensembl Protein

ENSCJAP00000007701

UniProt Accession

F6Y8M9;

Protein Name

Protein Synonyms/Alias

Gene Name

DDR2

Gene Synonyms/Alias

DDR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000004221	ENSCJAP00000007701	ENSCJAT00000008142
ENSCJAG00000004221	ENSCJAP00000007708	ENSCJAT00000008150
ENSCJAG00000004221	ENSCJAP00000051615	ENSCJAT00000059294

Organism

Callithrix jacchus

Functional Description

Protein Length

855

Protein Sequence
(FASTA)

MILIPRMLLV LFLLLPVLSS AKAQVNPAVC RYPLGMSGGQ IPDEDITASS QWSESTAAKY 60

GRLDSEEGDG AWCPEIPVEP DDLKEFLQID LHTLHFITLV GTQGRHAGGH GIEFAPMYKI 120

NYSRDGTRWI SWRNRHGKQV LDGNSNPYDI FLKDLEPPIV ARFVRFIPVT DHSMNVCMRV 180

ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 240

DFTQTHEYHV WPGYDYVGWR NESATNGYIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 300

EVQCYFRSDA SEWEPNAISF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 360

EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 420

WRQFWQKMLE KASRRMLDDE MTVSLSLPSD SSMFNNNRSS SPSEQESNST YDRIFPLRPD 480

YQEPSRLIRK LPEFAPGEEE SGCSGVVKPV QPSGPEGVPH YAEADIVNLQ GVTGGNTYSV 540

PAVTMDLLSG KDVAVEEFPR KLLTFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSVN 600

QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIHL LAVCITDDPL CMITEYMENG 660

DLNQFLSRHE PPNSSSSNVP TVSYTNLKFM ATQIASGMKY LSSLNFVHRD LATRNCLVGK 720

NYTIKIADFG MSRNLYSGDY YRIQGRAVLP IRWMSWESIL LGKFTTASDV WAFGVTLWET 780

FTFCQEQPYS QLSDEQVIEN TGEFFRDQGR QTYLPQPAIC PDSVYKLMLS CWRRDTKHRP 840

SFQEIHLLLL QQGDE 855

Nucleotide Sequence
(FASTA)

ATGATCCTGA TTCCCAGAAT GCTCTTGGTG CTGTTCCTGC TGCTGCCTGT CTTGAGTTCT 60

GCAAAAGCTC AGGTTAATCC AGCTGTATGC CGTTATCCTC TGGGCATGTC AGGAGGCCAG 120

ATTCCAGACG AGGACATCAC AGCTTCCAGT CAGTGGTCAG AGTCCACAGC TGCCAAATAT 180

GGAAGGCTGG ACTCAGAAGA AGGGGATGGA GCCTGGTGCC CTGAGATTCC AGTGGAACCT 240

GATGACCTGA AGGAGTTTCT ACAGATTGAC TTACATACCC TCCATTTTAT CACTCTTGTG 300

GGGACCCAGG GGCGCCATGC AGGGGGTCAC GGCATTGAGT TTGCCCCCAT GTACAAGATC 360

AACTACAGTC GAGATGGCAC TCGCTGGATC TCTTGGCGGA ATCGTCACGG GAAACAGGTG 420

CTGGATGGAA ATAGTAACCC CTATGACATT TTCCTAAAGG ACTTGGAGCC ACCTATTGTG 480

GCCAGATTTG TCCGGTTCAT TCCAGTCACT GACCACTCCA TGAATGTGTG CATGAGGGTG 540

GAGCTTTATG GCTGTGTGTG GCTAGATGGC TTGGTGTCAT ACAATGCTCC AGCTGGGCAG 600

CAGTTTGTAC TCCCTGGGGG CTCCATCATT TATCTGAATG ATTCTGTCTA TGATGGAGCT 660

GTTGGGTACA GCATGACAGA AGGGCTAGGC CAGTTGACAG ATGGTGTGTC TGGCTTGGAT 720

GATTTCACCC AGACCCATGA ATACCACGTG TGGCCTGGCT ATGACTATGT GGGCTGGCGG 780

AACGAGAGTG CCACCAATGG CTACATTGAG ATCATGTTTG AATTTGACCG CATCAGGAAT 840

TTCACTACCA TGAAGGTCCA CTGCAACAAC ATGTTTGCTA AAGGTGTGAA GATCTTTAAG 900

GAGGTACAGT GCTACTTCCG CTCTGATGCC AGTGAGTGGG AACCTAATGC CATTTCCTTC 960

CCCCTTGTCC TGGATGACGT CAACCCCAGC GCTCGGTTTG TCACAGTGCC TCTCCACCAC 1020

CGAATGGCCA GTGCCATCAA GTGCCAATAC CATTTTGCTG ATACCTGGAT GATGTTCAGT 1080

GAGATCACCT TCCAATCAGA TGCTGCAATG TACAACAACT CTGGAGCCCT ACCCACCTCT 1140

CCTATGGCAC CCACAACCTA TGATCCAATG CTTAAAGTTG ATGACAGCAA CACTAGGATC 1200

CTGATTGGCT GCTTGGTGGC CATCATCTTC ATCCTCCTGG CCATCATTGT CATCATACTC 1260

TGGAGGCAGT TCTGGCAGAA AATGCTGGAG AAGGCTTCTC GGAGGATGCT GGATGATGAA 1320

ATGACAGTGA GCCTTTCCTT GCCAAGTGAT TCCAGCATGT TCAACAATAA CCGCTCCTCA 1380

TCACCTAGTG AACAAGAGTC CAACTCGACT TATGATCGCA TCTTTCCCCT TCGTCCTGAC 1440

TACCAGGAGC CATCCAGGCT GATACGAAAG CTCCCAGAAT TTGCTCCAGG GGAGGAGGAG 1500

TCAGGCTGCA GCGGCGTTGT GAAGCCAGTC CAGCCCAGTG GCCCTGAGGG GGTGCCCCAC 1560

TACGCAGAGG CTGACATAGT GAACCTCCAG GGAGTGACAG GAGGCAACAC ATACTCAGTG 1620

CCTGCCGTCA CCATGGACCT GCTCTCAGGA AAAGATGTGG CTGTGGAGGA GTTCCCCAGG 1680

AAACTCTTAA CTTTCAAAGA GAAGCTGGGA GAAGGCCAGT TTGGGGAGGT TCATCTCTGT 1740

GAAGTGGAGG GAATGGAAAA GTTCAAAGAC AAAGATTTTG CCCTAGATGT CAGTGTCAAC 1800

CAGCCTGTCC TGGTGGCCGT GAAAATGCTC CGAGCAGATG CCAACAAGAA CGCCAGGAAT 1860

GATTTTCTTA AGGAGATAAA GATCATGTCC CGACTCAAGG ACCCCAACAT CATCCATCTC 1920

TTAGCTGTGT GTATCACTGA TGATCCTCTC TGCATGATCA CTGAATACAT GGAGAATGGA 1980

GATCTCAATC AGTTTCTATC CCGCCACGAG CCCCCTAATT CTTCCTCCAG CAATGTACCC 2040

ACTGTCAGTT ACACCAACCT GAAGTTCATG GCTACCCAAA TTGCTTCTGG CATGAAGTAC 2100

CTTTCCTCTC TTAATTTTGT TCACCGAGAT CTGGCCACAC GAAACTGCTT AGTGGGTAAG 2160

AACTACACAA TCAAGATAGC TGACTTTGGA ATGAGCAGGA ACCTGTACAG TGGTGACTAT 2220

TACCGGATCC AGGGCCGGGC AGTGCTCCCT ATCCGTTGGA TGTCTTGGGA GAGTATCTTA 2280

CTGGGCAAGT TCACAACGGC AAGTGACGTG TGGGCCTTTG GGGTTACTTT GTGGGAGACT 2340

TTCACCTTTT GCCAGGAACA GCCCTATTCC CAGCTGTCAG ATGAACAGGT TATTGAGAAT 2400

ACTGGAGAGT TCTTCCGAGA CCAAGGGAGG CAGACTTACC TCCCTCAGCC AGCCATTTGC 2460

CCTGACTCTG TGTATAAGCT GATGCTCAGC TGCTGGAGAA GAGATACCAA GCACCGTCCC 2520

TCATTCCAAG AAATCCACCT TCTGCTCCTT CAACAAGGTG ACGAGTGA 2568

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55

         L++keklGeG+fgev+lCeveg+e++k+kd     s ++++lvavk+lr+danknar+df

Q: 563   LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDfaldvSVNQPVLVAVKMLRADANKNARNDF  622

         789*******************************99************************

S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaedselakektl  115

         lkeiki+srlkdPni++ll+vc++d+plc+i+ey+enGdlnqfls+he+ +s++++ +t+

Q: 623   LKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSNVPTV  682

         ************************************************************

S: 116   syellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdyyr  175

         sy++l+++atqiasg+kyL+slnfvhrdlatrnclvg+++t+kiadfg+sr+ly+gdyyr

Q: 683   SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYR  742

         ************************************************************

S: 176   vqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvienag  235

         +qGravlPiRwm+wesillgkfttasDvWafgvtlwe++t+c+eqPy++l+deqvien+g

Q: 743   IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTG  802

         ************************************************************

S: 236   elfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

         e+frdq+r+++l++Pa+cp+++y+l+l+Cwrrd+++RPsf+e+h+ll

Q: 803   EFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKHRPSFQEIHLLL  849

         ********************************************986

Domain Sequence
(FASTA)

LTFKEKLGEG QFGEVHLCEV EGMEKFKDKD FALDVSVNQP VLVAVKMLRA DANKNARNDF 60

LKEIKIMSRL KDPNIIHLLA VCITDDPLCM ITEYMENGDL NQFLSRHEPP NSSSSNVPTV 120

SYTNLKFMAT QIASGMKYLS SLNFVHRDLA TRNCLVGKNY TIKIADFGMS RNLYSGDYYR 180

IQGRAVLPIR WMSWESILLG KFTTASDVWA FGVTLWETFT FCQEQPYSQL SDEQVIENTG 240

EFFRDQGRQT YLPQPAICPD SVYKLMLSCW RRDTKHRPSF QEIHLLL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013