EKS-CAJ-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	394.9	4.3E-118	245	538	294

Status

Unreviewed

Ensembl Protein

ENSCJAP00000007949

UniProt Accession

F6Z930;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000004363	ENSCJAP00000007949	ENSCJAT00000008400
ENSCJAG00000004363	ENSCJAP00000007959	ENSCJAT00000008410
ENSCJAG00000004363	ENSCJAP00000007928	ENSCJAT00000008379

Organism

Callithrix jacchus

Functional Description

Protein Length

568

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPQVPK SVNNDIMVTD NNGAVKLPQL CKFCDVRFST 60

CDNQKSCMSN CSITAICEKP QEVCVAVWRK NDENITLETV CHDPRLPYHD FILEDAASPK 120

CIMKEKKKPG ETFFMCSCSS EECNDNIIFS EDYNTSNPDL LLVIFQVTGV SLLPPLAIAI 180

SVIIIFYCYR VNRQQKLSSS WETAKPRKLM EFSSEHCAII LEDDRSDISS TCANNINHNT 240

ELLPIELDTL VGKGRFAEVY KAKLKQNTSE QFETVAVKIF PYEEYASWKT EKDIFSDVNL 300

KHENILQFLT AEERKTELGK QYWLITAFHA KGNLQEYLTR HIISWEDLSK LGSSLARGIA 360

HLHSDHTPCG RPKVPIVHRD LKSSNILVKN DLTCCLCDFG LSLRLDPALS VDDLANSGQV 420

GTARYMAPEV LESRMNLENV ESFKQTDVYS MALVLWEMTS RCNAVGEVKD YEPPFGSKVR 480

EHPCVESMKD NVLRDRGRPE IPSFWLNHQG IQMVCETLTE CWDHDPEARL TAQCVAERFS 540

ELEHLDRLSG RSCSEEKIPE DGSLNTTK 568

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGCATC 60

GCCAGCACGA TCCCACCGCA AGTTCCGAAG TCGGTTAATA ACGACATCAT GGTCACCGAC 120

AACAATGGTG CAGTCAAGCT TCCACAACTG TGTAAATTTT GTGATGTGAG ATTTTCCACC 180

TGTGACAACC AGAAGTCCTG CATGAGCAAC TGTAGTATCA CCGCCATCTG TGAGAAGCCA 240

CAGGAAGTCT GTGTGGCTGT ATGGAGAAAG AATGACGAGA ACATAACACT AGAGACTGTT 300

TGCCATGACC CCAGGCTCCC CTACCATGAC TTTATTCTGG AAGATGCTGC TTCTCCAAAG 360

TGCATTATGA AGGAAAAAAA AAAGCCTGGC GAGACTTTCT TCATGTGTTC CTGTAGCTCT 420

GAAGAGTGCA ATGACAACAT CATCTTCTCA GAAGACTATA ACACCAGCAA TCCTGACTTG 480

CTGCTAGTCA TATTTCAAGT GACAGGCGTC AGCCTCCTGC CACCACTAGC AATCGCCATA 540

TCTGTCATCA TCATCTTCTA CTGCTATCGC GTGAACCGGC AGCAGAAGCT GAGTTCATCC 600

TGGGAAACCG CCAAGCCACG GAAGCTCATG GAGTTCAGCA GCGAGCACTG TGCCATCATC 660

CTGGAAGATG ACCGCTCCGA CATCAGCTCC ACGTGCGCCA ACAACATCAA CCACAACACG 720

GAGCTGCTGC CCATTGAGCT GGACACGCTG GTGGGGAAAG GTCGCTTTGC TGAGGTCTAT 780

AAGGCCAAGC TGAAGCAGAA CACTTCAGAG CAGTTTGAGA CAGTGGCAGT CAAGATCTTT 840

CCCTATGAGG AGTATGCCTC TTGGAAGACG GAGAAGGACA TCTTCTCAGA TGTCAACCTG 900

AAGCATGAGA ACATACTCCA GTTCCTGACG GCCGAGGAGC GGAAGACGGA GTTGGGGAAA 960

CAGTACTGGC TGATCACCGC CTTCCACGCC AAGGGCAACC TACAGGAGTA CCTGACACGG 1020

CATATCATCA GCTGGGAGGA CCTGAGCAAG CTGGGCAGCT CCCTCGCCCG GGGCATTGCT 1080

CACCTCCACA GTGATCACAC CCCTTGCGGG AGGCCCAAGG TGCCCATCGT GCACAGGGAC 1140

CTCAAGAGCT CCAATATCCT TGTGAAGAAC GACCTGACTT GCTGCCTGTG TGACTTTGGG 1200

CTTTCCCTGC GACTGGACCC TGCTCTGTCT GTGGATGACC TGGCTAACAG CGGGCAGGTG 1260

GGAACTGCAA GATACATGGC TCCAGAAGTC CTAGAATCCA GGATGAATTT GGAGAACGTT 1320

GAGTCCTTCA AGCAGACCGA TGTCTACTCC ATGGCTCTGG TGCTCTGGGA AATGACATCT 1380

CGCTGCAATG CAGTGGGAGA AGTAAAAGAT TATGAGCCTC CATTTGGTTC CAAAGTGCGG 1440

GAGCACCCCT GTGTCGAGAG CATGAAGGAC AACGTGTTGA GAGATCGAGG ACGACCAGAA 1500

ATTCCCAGCT TCTGGCTCAA CCACCAGGGC ATCCAGATGG TGTGTGAGAC GTTGACTGAG 1560

TGCTGGGACC ACGACCCGGA GGCCCGTCTC ACAGCCCAGT GTGTGGCGGA ACGCTTCAGT 1620

GAGCTGGAGC ACCTGGACAG GCTCTCGGGG AGGAGCTGCT CTGAGGAGAA GATTCCTGAA 1680

GACGGCTCCC TAAACACTAC CAAATAG 1707

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ v+l+hen

Q: 245   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDVNLKHEN  304

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 305   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHIISWEDLSKLGSSLARGIAHLHS  364

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 365   D-HTPCGRPKVPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPALSVDDLANSGQVGTA  423

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 424   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  482

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 483   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  538

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDVNLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHIIS WEDLSKLGSS LARGIAHLHS 120

DHTPCGRPKV PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPALSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013