EKS-CAJ-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	422.1	1.5E-126	92	345	254

Status

Unreviewed

Ensembl Protein

ENSCJAP00000008347

UniProt Accession

F7HTM9;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000004595	ENSCJAP00000008357	ENSCJAT00000008836
ENSCJAG00000004595	ENSCJAP00000008347	ENSCJAT00000008825

Organism

Callithrix jacchus

Functional Description

Protein Length

363

Protein Sequence
(FASTA)

MDTTLLLPNP WIRVLDGGVV KHYRIRRLDE GGFFLTRRRT FSTLNEFVSH YTKTSDGLCV 60

KLGKPCLKIQ VPAPFDLSYK TVDQWEIDRN SIQLLKRLGS GQFGEVWEGL WNNTTPVAVK 120

TLKPGSMDPN DFLREAQIMK NLRHPKLIQL YAVCTLEDPI YIITELMRHG SLQEYLQNDA 180

GSKIHLTQQV DIAAQVASGM AYLESQNYIH RDLAARNVLV GEHNIYKVAD FGLARVFKVD 240

NEDIYESKHE IKLPVKWTAP EAIRTNKFSI KSDVWSFGIL LYEIITYGKM PYSGMTGAQV 300

IQVLAQNYRL PQPSNCPQKF YNIMLECWNA EPKERPTFET LHWKLEDYFE TESSYSDANN 360

FIR 363

Nucleotide Sequence
(FASTA)

ATGGATACAA CTTTATTACT ACCTAATCCA TGGATAAGAG TTTTAGATGG AGGAGTTGTA 60

AAACACTACA GAATCAGAAG ACTGGATGAA GGGGGCTTTT TTCTCACCCG GAGAAGAACC 120

TTTTCAACAC TGAACGAGTT TGTGAGCCAC TACACCAAGA CAAGTGACGG CCTGTGTGTC 180

AAGCTGGGGA AACCATGCTT AAAGATCCAG GTCCCAGCTC CGTTTGATTT GTCATACAAA 240

ACTGTGGACC AGTGGGAGAT AGACCGCAAC TCCATACAGC TTCTGAAGCG ATTGGGATCT 300

GGTCAGTTTG GCGAAGTATG GGAAGGTCTG TGGAACAATA CCACTCCAGT AGCAGTGAAA 360

ACATTAAAAC CAGGTTCAAT GGATCCAAAT GACTTCCTGA GGGAGGCACA GATAATGAAG 420

AACCTAAGAC ATCCAAAGCT TATCCAGCTT TACGCTGTTT GCACTTTAGA AGATCCAATT 480

TATATTATCA CAGAGTTGAT GAGACATGGA AGTCTGCAAG AATATCTCCA AAATGATGCT 540

GGGTCAAAAA TCCATCTGAC TCAACAGGTA GATATAGCGG CACAGGTTGC CTCTGGAATG 600

GCCTATCTGG AGTCTCAGAA CTACATTCAC AGAGATCTGG CTGCCAGAAA TGTCCTCGTT 660

GGTGAACATA ATATCTACAA AGTAGCAGAT TTTGGACTTG CCAGAGTTTT TAAGGTAGAC 720

AATGAAGACA TCTATGAATC TAAACACGAA ATAAAGCTGC CGGTGAAGTG GACTGCACCC 780

GAAGCCATTC GTACTAATAA ATTCAGCATT AAGTCCGATG TGTGGTCATT TGGAATCCTT 840

CTTTATGAAA TCATTACTTA TGGCAAAATG CCTTATAGTG GTATGACAGG TGCCCAGGTA 900

ATTCAGGTGC TGGCTCAAAA CTATAGACTT CCGCAACCAT CCAACTGTCC ACAGAAGTTT 960

TACAACATCA TGTTGGAGTG TTGGAATGCA GAGCCTAAGG AACGACCTAC ATTTGAGACA 1020

CTGCACTGGA AACTTGAGGA CTATTTTGAA ACGGAATCTT CATATTCAGA TGCAAATAAC 1080

TTTATAAGAT GA 1092

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 92    IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  151

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 152   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLTQQVDIAAQVASGMAYLESQNYIHR  211

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 212   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  271

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++ + ++yrlp+p++cp+++y+++lecw+++

Q: 272   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQVLAQNYRLPQPSNCPQKFYNIMLECWNAE  331

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 332   PKERPTFETLHWKL  345

         **********9986

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLTQQVD IAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QVLAQNYRLP QPSNCPQKFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013