EKS-CAJ-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.9	9.7E-145	1049	1309	261

Status

Reviewed

Ensembl Protein

ENSCJAP00000045170

UniProt Accession

Q2QLG5;

Protein Name

Hepatocyte growth factor receptor

Protein Synonyms/Alias

HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000005145	ENSCJAP00000009431	ENSCJAT00000009968
ENSCJAG00000005145	ENSCJAP00000009442	ENSCJAT00000009981
ENSCJAG00000005145	ENSCJAP00000045170	ENSCJAT00000057450
ENSCJAG00000005145	ENSCJAP00000048702	ENSCJAT00000056402
ENSCJAG00000005145	ENSCJAP00000046193	ENSCJAT00000060824

Organism

Callithrix jacchus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).

Protein Length

1352

Protein Sequence
(FASTA)

LTMKAPAVLA PGILVLLFTL VQRSNGECKE ALTKSEMNVN MKYQLPNFTA ETPIQNVILH 60

EHHIFLGATN YIYVLNEEDL QKVAEYRTGP VLEHPDCFPC QDCSSKANLS GGVWKDNINM 120

ALVVDTYYDD QLISCGSVNR GTCQRHVFPH NHTADIQSEV HCIFSAQTEE PSQCPDCMVS 180

ALGTKVLLSV KDRFLNFFVG NTINSSYFPD HSLHSISVRR LKETKDGFMF LTDQSYVDVL 240

PEFRDSYPIK YVHAFESNNF IYFLTVQRET LNAQTFHTRI IRFCSINSAL HSYMEMPLEC 300

ILTEKRKKRS TKKEVFNILQ AAYVSKPGAQ LARQIGASLN DDILFGVFAQ SKPDSAEPMD 360

RSAVCAFPIN HHRVIGVVSS ENLLYFCEYS TSEKLFSHGI DLLNESKHCP EYLGAGKSLP 420

QSHPKCHIQE LCVKSSLQRI DLFAGQFNKV LLTSISTFIK GDLTIANLGT SEGRFIQIKV 480

ARNRKHLYFY SQVALGSSGL KLFYWYLLWH SNSLADSGNE ITKIPLNGLG CRHFQSCSQC 540

LSAPSFVQCG WCHDKCVRSE ECSSGTWTQE TCLPTIYKVF PTSAPLEGGT RLTICGWDFG 600

FRRNNKFDLK KTRVLLGNES CTLTLSESTM NTAVNVKYIF SRLKCTVGPA MNERFNMSII 660

ISNAHGTTQY STFSYVDPII TSISPRYGPM SGGTLLTLTG NYLNSGNSRH ISIGGKTCTL 720

KSVSNSILEC YTPAQSISTE FPVKLKIDLA NRETSIFSYR EDPIVYEIYP TKSFVSLATI 780

VLGGKNLSIL SIFLFRFASG GSTITGIGKN LNSVSVPRMV INLHEAKRNF TVVWLVWESP 840

YEAKGFETNP HTWPQTKYIM SQKPVVHCIV LKFLVSVGIS NCFISNYTCQ RKACQHRSNS 900

EIICCTTPSL QQLNLQLPLK TKAFFIINIL TMTVHSSMSN LMQKILLISL SVVSISIALL 960

LLLGLFLWLK KKKLVSARSV SPTTEMVSNE SVDYRATFPE DMSPILTSGD SDISSPLLQN 1020

TVHIDLSALN PELVQAVQHV VIGPSSLIVH FNEVIGRGHF GCVYHGTLLD NDGKKIHCAV 1080

KSLNRITDIG EVSQFLTEGI IMKDFSHPNV LSLLGICLRS EGSPLVVLPY MKHGDLRNFI 1140

RNETHNPTVK DLIGFGLQVA KGMKYLASKK FVHRDLAARN CMLDEKFTVK VADFGLARDM 1200

YDKEYYSVHN KTGAKLPVKW MALESLQTQK FTTKSDVWSF GVLLWELMTR GAPPYPDVNT 1260

FDITVYLLQG RRLLQPEYCP DPLYEVMLKC WHPKAEMRPS FSELVSRISA IFSTFIGEHY 1320

VHVNATYVNV KCVAPYPSLL SSQDNTDGEV DT 1352

Nucleotide Sequence
(FASTA)

CTCACAATGA AGGCCCCCGC TGTGCTTGCA CCTGGCATCC TCGTGCTCCT GTTTACCTTG 60

GTGCAGAGGA GCAATGGGGA GTGTAAAGAG GCACTAACGA AGTCTGAGAT GAATGTGAAT 120

ATGAAATATC AGCTTCCCAA CTTCACTGCA GAAACACCCA TCCAGAATGT CATTCTACAT 180

GAGCATCACA TTTTCCTTGG TGCCACTAAC TACATTTATG TTTTAAATGA GGAAGACCTT 240

CAGAAGGTTG CTGAGTACAG GACGGGGCCT GTGCTAGAAC ACCCAGATTG TTTCCCATGT 300

CAGGACTGCA GCAGCAAAGC CAATTTATCA GGAGGAGTTT GGAAAGATAA CATCAACATG 360

GCTCTGGTTG TCGACACCTA CTATGATGAC CAACTCATTA GCTGTGGCAG CGTCAACAGA 420

GGAACCTGCC AGCGACACGT CTTTCCCCAC AATCATACTG CTGACATTCA GTCGGAGGTT 480

CACTGCATAT TCTCCGCGCA GACAGAAGAG CCCAGCCAGT GTCCTGACTG CATGGTGAGC 540

GCCCTGGGAA CCAAAGTCCT TTTATCTGTA AAGGACCGGT TCCTCAACTT CTTTGTAGGC 600

AATACCATAA ATTCTTCTTA CTTCCCAGAT CATTCATTGC ATTCGATATC AGTGAGAAGG 660

CTAAAGGAAA CAAAAGATGG TTTTATGTTT TTGACGGACC AGTCCTACGT TGATGTTTTA 720

CCTGAGTTCA GAGATTCTTA CCCCATTAAG TACGTCCATG CCTTTGAAAG CAACAATTTT 780

ATTTACTTCT TGACGGTCCA AAGGGAAACT CTAAATGCTC AGACTTTTCA CACAAGAATA 840

ATCAGGTTCT GTTCCATAAA CTCTGCATTG CATTCCTACA TGGAAATGCC TCTGGAGTGT 900

ATTCTCACAG AAAAGCGAAA AAAGAGATCC ACAAAAAAGG AAGTGTTTAA TATCCTTCAG 960

GCTGCATATG TCAGCAAGCC TGGGGCCCAA CTTGCGAGGC AAATAGGAGC CAGCCTGAAT 1020

GATGACATTC TCTTCGGGGT GTTTGCACAA AGCAAGCCAG ATTCTGCCGA ACCAATGGAT 1080

CGATCGGCCG TGTGTGCATT CCCTATCAAT CATCACAGGG TAATTGGTGT TGTGTCTTCT 1140

GAAAATCTCT TATACTTCTG TGAATACTCA ACAAGTGAAA AATTATTTTC CCATGGTATA 1200

GATCTTCTAA ATGAATCAAA ACATTGCCCA GAATATCTGG GTGCAGGAAA AAGTTTGCCC 1260

CAATCCCACC CTAAATGCCA CATCCAGGAA CTGTGTGTGA AATCTTCTTT GCAGCGCATT 1320

GACTTATTCG CAGGTCAATT CAACAAAGTC CTCTTAACGT CTATATCCAC CTTCATTAAA 1380

GGAGACCTCA CCATTGCTAA TCTTGGGACA TCAGAGGGCC GCTTCATCCA GATTAAGGTA 1440

GCAAGGAATA GAAAACATTT GTACTTTTAC TCACAAGTGG CTCTTGGGAG CTCAGGGTTG 1500

AAGCTTTTTT ATTGGTATTT ACTCTGGCAC TCCAACAGTC TAGCAGATTC AGGAAATGAG 1560

ATCACCAAGA TCCCATTGAA TGGTTTGGGC TGCAGACATT TCCAGTCCTG CAGTCAGTGC 1620

CTCTCTGCTC CTTCCTTTGT GCAGTGTGGC TGGTGCCACG ATAAATGTGT GCGATCAGAG 1680

GAATGCTCCA GCGGGACATG GACTCAAGAG ACCTGTCTGC CTACAATCTA CAAGGTTTTC 1740

CCAACTAGTG CACCCCTTGA AGGAGGGACA AGGCTGACCA TATGTGGCTG GGACTTTGGA 1800

TTTCGGAGGA ATAATAAATT CGATTTAAAG AAAACTAGAG TTCTCCTTGG AAATGAGAGC 1860

TGCACCTTGA CCTTAAGTGA GAGCACAATG AATACTGCAG TTAATGTAAA GTATATTTTT 1920

TCCAGATTGA AATGCACAGT TGGTCCTGCC ATGAATGAGC GTTTCAATAT GTCCATAATT 1980

ATTTCAAACG CCCACGGGAC AACACAATAC AGTACATTTT CCTATGTGGA CCCTATAATA 2040

ACAAGTATTT CCCCGAGATA CGGTCCTATG TCTGGTGGCA CTTTACTTAC TTTAACCGGA 2100

AATTACCTAA ACAGTGGGAA TTCTAGACAC ATTTCAATTG GTGGAAAAAC ATGTACTTTA 2160

AAAAGTGTGT CAAACAGTAT TCTTGAATGT TATACCCCAG CCCAAAGCAT TTCAACTGAG 2220

TTTCCTGTTA AATTGAAAAT TGACTTAGCC AACCGAGAGA CAAGCATCTT CAGTTACCGG 2280

GAAGACCCTA TTGTCTATGA AATTTATCCA ACCAAATCTT TTGTTAGTCT AGCAACAATA 2340

GTACTTGGTG GAAAAAACCT CTCAATATTG TCAATTTTTC TATTTCGATT TGCCAGTGGT 2400

GGGAGCACAA TAACAGGTAT TGGGAAAAAC CTGAATTCAG TTAGTGTTCC GAGGATGGTC 2460

ATAAATCTGC ATGAAGCAAA AAGGAACTTT ACTGTGGTTT GGTTGGTTTG GGAGTCACCA 2520

TATGAAGCAA AGGGTTTTGA AACCAATCCC CACACATGGC CACAAACAAA GTACATTATG 2580

TCCCAGAAGC CTGTAGTTCA TTGCATAGTT CTCAAATTTC TTGTTAGTGT GGGCATAAGT 2640

AATTGTTTTA TCTCCAACTA TACTTGCCAA AGAAAAGCAT GTCAGCATCG CTCTAATTCA 2700

GAGATAATCT GCTGTACCAC TCCTTCCCTG CAACAGCTGA ATCTGCAACT CCCCCTGAAA 2760

ACCAAAGCCT TTTTCATTAT TAATATATTA ACAATGACTG TGCATTCGTC AATGTCCAAT 2820

TTGATGCAAA AGATATTGTT AATTTCTTTG AGTGTTGTCT CAATCTCAAT AGCACTCTTA 2880

TTACTACTTG GGCTTTTCCT GTGGCTGAAA AAGAAAAAGC TTGTAAGTGC CCGAAGTGTA 2940

AGCCCAACTA CAGAAATGGT TTCAAATGAA TCTGTAGACT ACCGAGCTAC TTTTCCAGAA 3000

GACATGTCCC CTATCCTGAC TAGTGGGGAC TCTGATATAT CCAGTCCATT ACTGCAAAAT 3060

ACTGTCCACA TTGACCTCAG TGCTCTAAAT CCAGAGCTGG TCCAGGCAGT GCAGCATGTA 3120

GTGATTGGGC CCAGTAGCCT GATTGTGCAT TTCAATGAAG TCATAGGAAG AGGGCATTTT 3180

GGTTGTGTGT ATCATGGGAC TTTGCTGGAC AATGATGGCA AGAAAATTCA CTGTGCTGTG 3240

AAATCCTTGA ACAGAATCAC GGACATTGGA GAAGTTTCCC AGTTTCTGAC CGAGGGAATC 3300

ATCATGAAAG ATTTTAGTCA TCCCAATGTC CTTTCGCTCC TGGGAATCTG CCTGCGAAGT 3360

GAAGGGTCTC CACTGGTGGT CCTACCATAC ATGAAACATG GAGATCTTCG AAATTTCATT 3420

CGAAATGAGA CTCATAATCC AACTGTAAAA GATCTTATTG GCTTTGGTCT TCAAGTAGCC 3480

AAAGGCATGA AATATCTTGC AAGCAAAAAG TTTGTCCACA GAGACTTGGC TGCAAGAAAC 3540

TGTATGCTGG ATGAAAAATT CACTGTCAAG GTTGCTGATT TTGGCCTTGC CAGAGATATG 3600

TATGATAAAG AATACTATAG TGTACACAAC AAAACAGGTG CAAAGCTGCC GGTGAAGTGG 3660

ATGGCTCTGG AAAGTCTACA AACTCAAAAG TTTACCACCA AGTCAGACGT GTGGTCCTTT 3720

GGCGTACTCC TCTGGGAGCT GATGACAAGA GGAGCCCCAC CTTATCCTGA TGTGAACACT 3780

TTCGATATAA CTGTTTACCT GTTGCAAGGG AGAAGGCTCC TGCAACCCGA ATACTGCCCA 3840

GACCCCTTAT ATGAAGTCAT GCTAAAATGC TGGCACCCTA AAGCTGAAAT GCGCCCATCC 3900

TTTTCCGAAC TCGTGTCCCG GATATCAGCG ATCTTCTCTA CTTTCATCGG GGAGCACTAT 3960

GTCCATGTGA ACGCTACTTA TGTGAACGTA AAATGTGTCG CTCCATATCC TTCTCTGTTG 4020

TCATCACAAG ATAACACTGA TGGCGAGGTG GACACATGA 4059

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1049  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1108

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1109  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1168

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1169  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1228

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1229  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1287

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1288  LKCWHPKAEMRPSFSELVSRIS  1309

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013