EKS-CAJ-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	515.6	3.7E-155	546	805	260

Status

Unreviewed

Ensembl Protein

ENSCJAP00000010645

UniProt Accession

F7HWL9;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB2

Gene Synonyms/Alias

EPHB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000005696	ENSCJAP00000010639	ENSCJAT00000011239
ENSCJAG00000005696	ENSCJAP00000010653	ENSCJAT00000011253
ENSCJAG00000005696	ENSCJAP00000010658	ENSCJAT00000011258
ENSCJAG00000005696	ENSCJAP00000010645	ENSCJAT00000011245

Organism

Callithrix jacchus

Functional Description

Protein Length

911

Protein Sequence
(FASTA)

LPTETLMDST TATAELGWMV HPPSGWEEVS GYDENMNTIR TYQVCNVFES SQNNWLRTKF 60

IRRRGAHRIH VEMKFSVRDC SSIPSVPGSC KETFNLYYYE ADFDSATKTF PNWMENPWVK 120

VDTIAADESF SQVDLGGRVM KINTEVRSFG PVSRSGFYLA FQDYGGCMSL IAVRVFYRKC 180

PRIIQNGAIF QETLSGAEST SLVAARGSCI ANAEEVDVPI KLYCNGDGEW LVPIGRCMCK 240

AGFEAVENGT VCRGCPSGTF KANQGDEACT HCPINSRTTS EGATNCVCRN GYYRADLDPL 300

DMPCTTIPSA PQAVISSVNE TSLMLEWTPP RDSGGREDLV YNIICKSCGS GRGACTRCGD 360

NVQYAPRQLG LTEPRIYISD LLAHTQYTFE IQAVNGVTDQ SPFSPQFASV NITTNQAAPS 420

AVSIMHQVSR TVDSITLSWS QPDQPNGVIL DYELQYYEKE LSEYNATAIK SPTNTVTVQG 480

LKAGAIYVFQ VRARTVAGYG RYSGKMYFQT MTEVTPGMKI YIDPFTYEDP NEAVREFAKE 540

IDISCVKIEQ VIGAGEFGEV CSGHLKLPGK REIFVAIKTL KSGYTEKQRR DFLSEASIMG 600

QFDHPNVIHL EGVVTKSTPV MIITEFMENG SLDSFLRQND GQFTVIQLVG MLRGIAAGMK 660

YLADMNYVHR DLAARNILVN SNLVCKVSDF GLSRFLEDDT SDPTYTSALG GKIPIRWTAP 720

EAIQYRKFTS ASDVWSYGIV MWEVMSYGER PYWDMTNQDV INAIEQDYRL PPPMDCPSAL 780

HQLMLDCWQK DRNHRPKFGQ IVNTLDKMIR NPNSLKAMAP LSSGINLPLL DRTIPDYTSF 840

NTVDEWLEAI KMGQYKESFA NAGFTSFDVV SQMMMEDILR VGVTLAGHQK KILNSIQVMR 900

AQMNQIQSVE V 911

Nucleotide Sequence
(FASTA)

CTCCCCACAG AAACGCTAAT GGACTCCACT ACAGCGACGG CTGAGCTGGG CTGGATGGTG 60

CATCCTCCAT CAGGGTGGGA AGAGGTGAGT GGCTACGATG AGAACATGAA CACGATCCGC 120

ACGTACCAGG TATGCAACGT GTTTGAGTCA AGCCAGAACA ACTGGCTACG GACCAAGTTC 180

ATCCGGCGCC GTGGTGCCCA CCGCATCCAC GTGGAGATGA AGTTTTCGGT GCGTGACTGC 240

AGCAGCATCC CCAGCGTGCC TGGCTCCTGC AAGGAGACCT TCAACCTCTA TTACTATGAG 300

GCTGACTTTG ACTCGGCCAC CAAGACCTTC CCCAACTGGA TGGAGAATCC ATGGGTGAAG 360

GTGGATACTA TCGCAGCCGA TGAGAGCTTC TCGCAGGTGG ACCTGGGTGG CCGCGTCATG 420

AAAATCAACA CCGAGGTGCG CAGCTTCGGA CCTGTATCCC GCAGCGGCTT CTACCTGGCC 480

TTCCAGGACT ACGGTGGCTG CATGTCCCTC ATCGCTGTGC GTGTCTTCTA CCGCAAGTGC 540

CCCCGCATCA TTCAGAACGG CGCCATCTTC CAGGAAACCC TGTCGGGGGC TGAGAGCACA 600

TCACTGGTGG CTGCCCGGGG CAGCTGCATC GCCAATGCGG AAGAGGTGGA TGTGCCCATC 660

AAGCTCTACT GTAATGGGGA CGGCGAGTGG CTGGTGCCCA TTGGGCGCTG CATGTGCAAA 720

GCAGGCTTCG AGGCCGTGGA GAATGGCACC GTCTGCCGAG GTTGCCCATC TGGAACTTTC 780

AAGGCCAACC AAGGGGACGA GGCCTGTACC CACTGCCCCA TCAACAGCCG CACCACTTCC 840

GAAGGGGCCA CCAACTGTGT CTGCCGCAAT GGCTACTACA GAGCAGACCT GGACCCCCTG 900

GACATGCCCT GCACCACCAT CCCCTCGGCA CCCCAGGCTG TGATTTCCAG CGTGAATGAG 960

ACCTCCCTCA TGCTGGAGTG GACCCCTCCC CGTGACTCCG GAGGCCGAGA GGACCTCGTC 1020

TACAACATCA TCTGCAAGAG CTGCGGCTCA GGCAGGGGCG CCTGCACCCG CTGTGGGGAC 1080

AACGTGCAGT ATGCCCCGCG CCAGCTGGGC CTGACCGAGC CACGCATTTA CATCAGTGAC 1140

CTGCTGGCCC ACACCCAATA CACCTTCGAG ATCCAGGCCG TGAATGGCGT TACTGACCAG 1200

AGCCCCTTCT CGCCTCAGTT CGCCTCTGTG AACATCACCA CCAACCAGGC AGCTCCGTCC 1260

GCAGTGTCCA TCATGCATCA GGTGAGCCGC ACCGTGGACA GCATTACCCT GTCGTGGTCC 1320

CAGCCAGACC AGCCCAATGG CGTGATCCTG GACTATGAGC TGCAGTACTA TGAGAAGGAG 1380

CTCAGTGAGT ACAACGCCAC AGCCATAAAA AGCCCCACCA ACACGGTCAC CGTGCAGGGC 1440

CTCAAAGCCG GCGCCATCTA TGTCTTCCAG GTGCGGGCAC GCACCGTGGC AGGCTACGGG 1500

CGCTACAGTG GCAAGATGTA CTTCCAGACC ATGACAGAAG TGACCCCAGG CATGAAGATC 1560

TACATCGACC CTTTCACCTA CGAGGACCCC AACGAGGCAG TGAGGGAGTT TGCCAAGGAA 1620

ATTGACATCT CCTGTGTCAA AATTGAGCAG GTGATCGGAG CAGGGGAGTT TGGTGAGGTC 1680

TGCAGCGGCC ACCTGAAGCT TCCAGGCAAG AGAGAGATCT TTGTGGCCAT CAAGACACTC 1740

AAGTCAGGCT ATACGGAGAA GCAGCGCAGG GACTTCCTGA GTGAAGCCTC CATCATGGGC 1800

CAGTTTGACC ACCCCAATGT CATCCACCTG GAGGGTGTCG TGACCAAGAG CACACCTGTG 1860

ATGATCATCA CTGAGTTCAT GGAAAATGGC TCCCTGGACT CCTTTCTCCG GCAAAACGAT 1920

GGGCAGTTCA CGGTCATCCA GCTGGTGGGC ATGCTTCGGG GCATTGCAGC CGGCATGAAG 1980

TACCTGGCAG ACATGAACTA TGTGCACCGT GACCTAGCTG CCCGCAACAT CCTTGTTAAC 2040

AGCAACCTGG TCTGCAAGGT GTCAGACTTT GGGCTCTCAC GCTTTCTGGA GGACGATACC 2100

TCAGACCCCA CCTACACCAG TGCCCTGGGT GGGAAGATCC CCATCCGCTG GACAGCCCCG 2160

GAAGCTATCC AGTACCGGAA GTTCACCTCG GCCAGTGATG TGTGGAGCTA CGGCATTGTC 2220

ATGTGGGAGG TGATGTCCTA TGGGGAGCGG CCCTACTGGG ACATGACCAA CCAGGACGTA 2280

ATTAATGCTA TCGAGCAGGA CTATCGGCTG CCGCCACCCA TGGACTGCCC AAGCGCCCTG 2340

CACCAACTCA TGCTAGACTG TTGGCAGAAA GACCGCAACC ATCGGCCCAA GTTCGGCCAA 2400

ATTGTCAACA CACTAGACAA GATGATCCGA AATCCCAACA GCCTCAAAGC CATGGCGCCC 2460

CTCTCCTCCG GCATCAACCT GCCGCTGCTG GACCGCACGA TACCTGACTA CACCAGCTTT 2520

AACACGGTGG ATGAGTGGCT GGAGGCCATC AAGATGGGGC AGTACAAGGA GAGCTTTGCC 2580

AATGCCGGCT TCACCTCCTT TGATGTCGTG TCTCAGATGA TGATGGAGGA CATTCTCCGG 2640

GTTGGGGTCA CTTTGGCTGG CCACCAGAAA AAAATCCTGA ACAGTATCCA GGTGATGCGG 2700

GCGCAGATGA ACCAGATTCA GTCTGTGGAG GTTTGA 2736

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp

Q: 546   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  605

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm

Q: 606   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  665

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y

Q: 666   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  725

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml

Q: 726   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  785

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqkdr++rpkf qiv++l

Q: 786   DCWQKDRNHRPKFGQIVNTL  805

         *****************975

Domain Sequence
(FASTA)

VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60

NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240

DCWQKDRNHR PKFGQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Canis familiaris"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013