EKS-CAJ-00215

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00215

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.2	2.5E-139	4	288	285

Status

Unreviewed

Ensembl Protein

ENSCJAP00000010763

UniProt Accession

F7IAS7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000005834	ENSCJAP00000010763	ENSCJAT00000011369
ENSCJAG00000005834	ENSCJAP00000010773	ENSCJAT00000011379

Organism

Callithrix jacchus

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

MNKFEILGVV GEGAYGVVLK CRHKETHEIV AIKKFKDSEE NEEVKETTLR ELKMLRTLKQ 60

ENIVELKEAF RRRGKLYLVF EYVEKNMLEL LEEMPNGVPP EKVKSYIYQL IKAIHWCHKN 120

DIVHRDIKPE NLLISHNDVL KLCDFGFARN LSEGNNANYT EYVATRWYRS PELLLGAPYG 180

KSVDMWSVGC ILGELSDGQP LFPGESEIDQ LFTIQKVLGP LPSEQMKLFY SNPRFHGLRF 240

PAVNHPQSLE RRYLGILNSV LLDLMKNLLK LDPADRYLTE QCLNHPTFQT QRLLDRSPSR 300

SAKRKPYHVE SSTLSNRNQA GKSTALQSHH RSNSKDIQNL SVGLPRADEG LPANESFLNG 360

NLAGASLSPM HTKTYQASSQ PGSTSKDLTN NNIPHLLSPK EAKSKTEFDF NIDPKPSEGP 420

GTKYLKSNSR SQQNRHSFME SSQSKAGTLQ PNEKQSRHSY IDTIPQSSRS PSYRTKAKSH 480

GALSDSKSVS NLSEARAQIT EPSSSRYFPS SCLDLNSPTS PTPTRHSDTR TLLSPSGRNN 540

RNEGTLDSRR TTTRHSKTME ELKLPEHMDS SHSHSLSAPH ESFSYGLGYT SPFSSQQRPH 600

RHSMYVTRDK VRAKGLDGSL SIGQGMAARA NSLQLLSPQP GEQLPPEMTV ARSSVKETSR 660

EGTSSFHTRQ KSEGGVYHDP HSDDGTAPKE NRHLYNDPMP RRVGSFYRGK PTPSIHQVPL 720

SSLSCFMPAA FSPTPLPSIY QPIFDPWKSP ENISHSEQLK EKEKQGFFRS MKKKKKKSQT 780

VPNSDSPDLL TLQKSIHSTS TPSSRPKEWR PEKISDLQTQ SQPLKSLRKL LHLSSTSNHP 840

ASSDPRFQPL TAQQTKNSFS EIRIHPLSQA SGGSSNIRQE PAPKGRPALQ LP 892

Nucleotide Sequence
(FASTA)

ATGAATAAAT TTGAGATCCT TGGGGTTGTA GGTGAAGGAG CCTATGGAGT TGTACTTAAA 60

TGCAGACACA AGGAAACACA TGAAATTGTG GCAATCAAGA AATTCAAGGA CAGTGAAGAA 120

AATGAAGAAG TCAAGGAAAC GACTTTACGA GAGCTTAAAA TGCTTCGGAC TCTCAAGCAG 180

GAAAACATTG TGGAGCTGAA GGAAGCATTT CGTCGGAGGG GAAAGTTGTA CTTGGTGTTT 240

GAGTATGTTG AAAAAAATAT GCTCGAATTG CTGGAAGAAA TGCCCAATGG AGTTCCACCT 300

GAGAAAGTGA AAAGCTATAT CTATCAGCTA ATCAAGGCTA TTCACTGGTG CCATAAGAAT 360

GATATTGTCC ATAGAGATAT AAAACCAGAA AATCTCTTAA TCAGCCACAA TGATGTCCTA 420

AAACTGTGTG ACTTTGGTTT TGCTCGTAAT CTGTCAGAAG GCAATAATGC TAATTACACA 480

GAGTACGTTG CCACCAGATG GTATCGATCC CCAGAACTCT TACTTGGCGC TCCCTATGGA 540

AAGTCCGTAG ACATGTGGTC GGTGGGCTGT ATTCTTGGGG AGCTTAGCGA TGGACAGCCT 600

TTATTTCCTG GAGAAAGTGA AATTGACCAA CTTTTTACTA TTCAGAAGGT GCTAGGACCA 660

CTTCCATCTG AGCAGATGAA GCTCTTCTAC AGTAATCCTC GCTTTCATGG GCTCCGGTTT 720

CCAGCTGTTA ACCATCCTCA GTCCTTGGAA AGAAGATACC TTGGAATTTT GAATAGTGTT 780

CTACTTGACC TAATGAAGAA TTTACTGAAG TTGGACCCAG CTGACAGATA CTTGACAGAA 840

CAGTGTTTGA ATCACCCTAC ATTTCAAACC CAGAGACTTC TGGATCGTTC TCCTTCAAGG 900

TCAGCAAAAA GAAAACCTTA CCATGTGGAA AGCAGCACAT TGTCTAATAG AAACCAAGCC 960

GGCAAAAGTA CTGCTTTGCA ATCTCACCAC AGATCTAACA GCAAAGACAT CCAGAATCTG 1020

AGTGTAGGCC TGCCCCGGGC TGATGAAGGT CTCCCTGCCA ATGAAAGCTT CCTAAATGGA 1080

AACCTTGCCG GAGCTAGTCT TAGCCCAATG CACACCAAAA CCTACCAAGC AAGCAGCCAG 1140

CCTGGGTCTA CCAGCAAAGA TCTCACCAAC AACAACATAC CACACCTTCT TAGCCCAAAA 1200

GAAGCCAAGT CAAAAACGGA GTTTGATTTT AATATTGACC CAAAGCCTTC AGAAGGCCCG 1260

GGGACAAAGT ACCTCAAGTC GAACAGCAGA TCTCAGCAGA ACCGCCACTC ATTCATGGAA 1320

AGCTCTCAGA GCAAAGCTGG GACACTGCAG CCCAATGAAA AGCAGAGTCG GCATAGCTAT 1380

ATCGACACCA TTCCCCAGTC CTCTAGGAGT CCCTCCTACA GGACCAAGGC CAAAAGCCAT 1440

GGGGCACTGA GTGACTCCAA GTCTGTTAGC AACCTTTCTG AAGCCAGGGC CCAAATTACG 1500

GAGCCCAGTA GCAGTAGGTA CTTCCCATCT AGCTGCTTAG ACTTGAATTC TCCCACCAGC 1560

CCAACCCCCA CCAGACACAG CGACACAAGA ACTTTGCTCA GCCCTTCAGG GAGAAATAAC 1620

CGAAATGAAG GAACGCTGGA CTCACGTCGA ACCACAACCA GACATTCTAA GACAATGGAG 1680

GAATTGAAGC TGCCCGAGCA CATGGACAGT AGCCATTCCC ATTCGCTGTC TGCACCTCAC 1740

GAATCTTTTT CTTATGGACT GGGCTATACG AGCCCCTTTT CTTCCCAGCA GCGTCCTCAT 1800

AGGCATTCTA TGTATGTGAC CCGTGACAAA GTGAGAGCCA AAGGCTTGGA TGGAAGCTTG 1860

AGCATAGGGC AAGGGATGGC AGCTAGAGCC AACAGCCTGC AACTCTTGTC ACCCCAGCCT 1920

GGAGAACAGC TCCCTCCAGA GATGACTGTA GCAAGATCAT CAGTCAAAGA GACCTCCAGA 1980

GAAGGCACCT CTTCCTTCCA TACACGCCAG AAGTCTGAGG GTGGAGTATA TCATGACCCA 2040

CACTCTGATG ATGGCACAGC CCCCAAAGAA AATAGACATC TGTATAATGA TCCCATGCCA 2100

AGGAGAGTCG GTAGCTTTTA CAGAGGTAAG CCCACCCCCA GCATTCACCA GGTTCCCCTC 2160

TCCTCCCTCT CTTGCTTTAT GCCAGCAGCC TTCTCACCTA CACCGTTGCC TTCTATCTAT 2220

CAACCTATAT TCGATCCATG GAAAAGTCCT GAAAATATTA GTCATTCAGA GCAACTCAAG 2280

GAAAAAGAGA AGCAAGGATT TTTCAGGTCA ATGAAAAAGA AAAAGAAGAA ATCTCAAACA 2340

GTACCCAATT CCGACAGCCC TGATCTTCTA ACGTTGCAGA AATCCATTCA TTCTACTAGC 2400

ACTCCAAGCA GCAGACCAAA GGAGTGGCGC CCTGAGAAAA TCTCAGATCT ACAGACCCAA 2460

AGCCAGCCAT TAAAATCACT GCGCAAGTTG TTACATCTCT CTTCCACCTC GAATCACCCG 2520

GCTTCCTCAG ATCCCCGCTT CCAGCCCTTA ACAGCTCAAC AAACCAAAAA TTCCTTCTCA 2580

GAAATTCGGA TTCACCCCTT GAGCCAGGCC TCTGGTGGGA GCAGCAACAT CCGGCAGGAG 2640

CCAGCACCGA AGGGCAGGCC AGCCCTCCAG CTGCCA 2676

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 4     FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  63

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 64    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 124   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  182

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 183   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  242

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 243   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  288

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013