EKS-CAJ-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAJ-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR513.22.6E-1549841251268
StatusUnreviewed
Ensembl ProteinENSCJAP00000011677
UniProt AccessionF7H833;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSRR
Gene Synonyms/Alias INSRR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCJAG00000006311ENSCJAP00000011677ENSCJAT00000012319
OrganismCallithrix jacchus
Functional Description
Protein Length1269
Protein Sequence
(FASTA)
MAVPGLWPWG ACLPAIVLSL GLGLDALEVC PSLDIRSEAA ELRRLENCSM VEGHLQILLM 60
FTATGDDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF LGYALVIFEM 120
PHLRDVGLPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP VPGANHIVGN KLGEECADVC 180
PGVLGAAGEP CAKTTFSGHT DYRCWTSSHC QRVCPCPHGL ACTARGECCH TECLGGCSRP 240
EDPRACVACR HLYFQGACLW ACPPGTYQYE SWRCVTAEHC ASLRSVPGRA STFGIHQGSC 300
LAQCPSGFTR NSSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLVDCTHV EGSLILNLRQ 360
GYNLEPQLQH SLGLVETITG FLKIKHSFAL VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ 420
NLQQLGSWVA AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 480
ACQTRTLRFV SNVTEADRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 540
QSWNLLDVEL PLSRTQEPGV TLGPLKPWTQ YAVFVRAITL TIAEDSPHQG AQSPIVYLRT 600
LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNLTYYLV LWQRLAEDSD LYLNDYCHRG 660
RQPVLLVSSR PRCQACGCPP ATTTRASTAK TGILRTRWSP DDALANTHLL VRFYPLWRNR 720
RPRSTRGLNT FLPMRSPSPS ANSARTVQQD PETEMESDFG IQEDKVPRER AVLSGLRHFT 780
EYRIDIHACN HAAQTVGCSA ATFVFARTMP HREADAIPGK VAWEASSKSS VLLRWFEPPD 840
PNGLILKYEI KYRRSGEEAT VLCVSRLRYA KFGGVHLALL PPGNYSARVR ATSLAGNGSW 900
TDSIAFYIPG PEEEDAGGLH VLLTATPVGL MLLIVLAALG FFYGKKSQRE VDKNRTLYAS 960
VNPEYFSASN MYIPDEWEVP REQISIIREL GQGSFGMVYE GLAQGLEAGE EPTPVALKTV 1020
NELASPRERI EFLKEASVMK AFKCHHVVRL LGVVSQGQPT LVIMELMTRG DLKSHLRSLR 1080
PEAENNPGLP QPALREMIQM AGEIADGMAY LAANKFVHRD LAARNCMVSQ DFTVKIGDFG 1140
MTRDVYETDY YRKGGKGLLP VRWMAPESLK DGIFTTHSDV WSFGVVLWEI VTLAEQPYQG 1200
LSNEQVLKFV MDGGVLEELE GCPLQLQELM SRCWQPNPRL RPAFTHILDS IQEELQPSFR 1260
HLSFYYSPE 1269
Nucleotide Sequence
(FASTA)
ATGGCAGTAC CTGGTCTGTG GCCCTGGGGA GCATGCCTGC CTGCGATCGT CCTCTCCTTG 60
GGACTTGGCC TGGATGCACT AGAGGTTTGC CCCAGCCTGG ACATTCGCTC AGAGGCAGCA 120
GAGCTTCGTC GGCTGGAGAA CTGCAGCATG GTGGAGGGCC ACCTGCAGAT CCTGCTCATG 180
TTCACAGCCA CCGGGGACGA CTTCCGCGGC CTCAGCTTCC CTCGCCTCAC CCAGGTCACC 240
GACTACCTGC TGCTCTTCCG TGTCTACGGA CTGGAGAGCC TGCGCGACCT CTTCCCCAAC 300
CTAGCCGTCA TCCGCGGGAC GCGCCTCTTC CTGGGCTATG CCCTGGTCAT CTTTGAGATG 360
CCGCATCTGC GTGACGTGGG ACTGCCTGCG CTTGGGGCCG TGCTGCGTGG GGCTGTGCGT 420
GTGGAGAAGA ACCAGGAGCT CTGCCACCTC TCCACCATTG ACTGGGGATT GCTGCAGCCG 480
GTACCTGGCG CCAACCACAT CGTGGGCAAC AAGCTGGGCG AGGAGTGTGC TGACGTGTGC 540
CCTGGTGTGC TGGGTGCTGC TGGCGAGCCC TGCGCCAAGA CCACCTTCAG TGGGCACACT 600
GACTACAGAT GCTGGACCTC CAGCCACTGC CAGAGAGTGT GCCCCTGCCC CCATGGGCTG 660
GCTTGCACAG CAAGGGGTGA GTGCTGCCAC ACCGAATGCC TGGGGGGCTG CAGCCGGCCA 720
GAAGACCCTC GTGCCTGTGT AGCTTGCCGT CACCTCTACT TTCAGGGTGC CTGCCTGTGG 780
GCCTGCCCTC CAGGCACCTA CCAGTATGAG TCCTGGCGCT GTGTCACAGC TGAGCACTGT 840
GCCAGCCTGC GCTCTGTGCC CGGCCGCGCC TCCACCTTCG GCATACACCA GGGCAGTTGC 900
CTGGCCCAGT GCCCTTCTGG CTTCACCCGT AATAGCAGCA GCATATTCTG CCACAAATGC 960
GAGGGGCTGT GCCCTAAAGA GTGCAAGGTA GGCACCAAGA CCATCGACTC CATCCAGGCG 1020
GCACAGGATC TGGTGGACTG CACGCATGTG GAGGGAAGCC TCATCCTCAA CCTTCGCCAG 1080
GGCTACAACC TGGAGCCGCA GCTGCAGCAC AGCCTGGGGC TGGTAGAGAC CATTACTGGC 1140
TTCCTCAAAA TCAAGCACTC CTTTGCCCTC GTGTCCCTGG GCTTTTTCAA GAACCTCAAG 1200
CTAATCCGAG GAGACGCCAT GGTAGATGGG AACTACACTC TCTATGTGCT GGACAACCAG 1260
AACCTACAGC AGCTAGGGTC CTGGGTGGCC GCGGGCCTCA CCATCCCCGT GGGCAAGATC 1320
TACTTCGCCT TCAACCCGCG CCTCTGCTTG GAGCACATCT ACCGACTGGA GGAGGTGACG 1380
GGCACGCGAG GTCGGCAGAA CAAGGCTGAG ATCAACCCCC GCACCAACGG AGACCGCGCC 1440
GCCTGCCAGA CTCGCACCCT GCGCTTCGTG TCCAACGTGA CGGAGGCAGA CCGCATCCTG 1500
CTACGCTGGG AGCGCTACGA GCCACTGGAG GCCCGCGACC TGCTCAGCTT CATAGTGTAC 1560
TACAAGGAGT CCCCATTCCA GAATGCCACA GAGCATGTGG GTCCAGATGC CTGTGGAACC 1620
CAGAGCTGGA ACCTGCTGGA TGTGGAGCTG CCCCTAAGCC GCACCCAGGA GCCAGGGGTG 1680
ACCCTAGGCC CCCTCAAGCC CTGGACACAG TACGCAGTGT TTGTGAGGGC CATCACGCTG 1740
ACCATTGCTG AGGACAGCCC CCATCAAGGA GCCCAGAGTC CCATCGTCTA TCTCAGAACG 1800
CTGCCTGCAG CTCCCACGGT GCCCCAAGAC GTCATCTCCA CATCTAACTC CTCCTCCCAC 1860
CTCCTGGTGC GCTGGAAGCC ACCGACCCAG CGCAATGGAA ACCTCACCTA CTACCTGGTG 1920
CTGTGGCAGC GGCTGGCAGA GGACAGCGAC CTCTACCTCA ATGACTACTG CCACCGCGGT 1980
AGACAGCCTG TCTTACTCGT GTCTTCCCGC CCGCGGTGCC AGGCTTGCGG CTGCCCACCA 2040
GCAACAACGA CCCGCGCTTC GACCGCGAAG ACGGGGATCC TGAGGACGAG ATGGAGTCCG 2100
GATGATGCCC TTGCCAACAC CCACCTCCTG GTCAGGTTCT ACCCTCTCTG GAGGAACAGG 2160
AGGCCTCGTT CAACAAGAGG TTTGAACACT TTTCTGCCGA TGCGATCACC ATCCCCAAGT 2220
GCTAATAGCG CGAGGACTGT GCAGCAGGAT CCTGAGACCG AGATGGAGTC CGATTTCGGG 2280
ATCCAAGAGG ACAAGGTGCC CCGTGAGCGA GCGGTGCTGA GCGGCCTGCG CCACTTCACG 2340
GAATACCGAA TAGACATCCA TGCCTGCAAC CACGCGGCGC AGACCGTGGG CTGCAGCGCC 2400
GCCACCTTCG TCTTCGCGCG CACCATGCCC CACAGAGAGG CTGATGCTAT TCCAGGAAAG 2460
GTGGCCTGGG AGGCCTCCAG CAAGAGCAGT GTCCTCCTGC GCTGGTTCGA GCCACCAGAC 2520
CCCAACGGAC TCATCCTCAA GTACGAAATC AAGTACCGCC GCTCGGGAGA GGAGGCCACA 2580
GTGCTGTGTG TGTCCCGTCT TCGATATGCA AAGTTTGGGG GAGTCCACCT GGCCCTGCTG 2640
CCCCCTGGAA ACTACTCTGC CAGGGTTCGG GCAACCTCAC TGGCTGGCAA TGGCTCTTGG 2700
ACAGACAGCA TTGCCTTCTA CATCCCTGGC CCAGAGGAGG AGGACGCTGG GGGGCTGCAC 2760
GTCCTCCTCA CTGCCACCCC CGTGGGGCTC ATGCTGCTCA TCGTTCTTGC TGCCCTTGGT 2820
TTCTTCTATG GCAAGAAGAG TCAAAGGGAG GTAGATAAAA ACAGAACCCT GTATGCTTCT 2880
GTGAATCCGG AGTACTTCAG CGCCTCCAAT ATGTACATCC CTGATGAGTG GGAAGTGCCT 2940
CGGGAGCAGA TCTCGATAAT CCGGGAACTG GGCCAGGGCT CTTTTGGGAT GGTATATGAG 3000
GGGCTGGCAC AAGGACTTGA GGCTGGAGAG GAGCCCACGC CCGTGGCCCT GAAGACGGTG 3060
AATGAGCTGG CCAGTCCACG GGAACGCATT GAGTTCCTCA AGGAAGCTTC TGTCATGAAG 3120
GCCTTCAAGT GTCACCATGT GGTGCGTCTC CTGGGTGTGG TGTCTCAGGG CCAGCCAACT 3180
CTGGTGATCA TGGAGTTGAT GACCCGTGGG GACCTCAAGA GCCATCTTCG ATCTTTGCGG 3240
CCTGAGGCAG AGAACAACCC TGGGCTCCCA CAGCCAGCAT TGAGGGAAAT GATCCAGATG 3300
GCTGGTGAGA TTGCAGATGG CATGGCCTAC CTTGCCGCCA ACAAGTTTGT GCACCGAGAC 3360
CTCGCAGCCC GCAACTGCAT GGTGTCCCAG GACTTCACCG TCAAGATCGG GGACTTCGGG 3420
ATGACTCGGG ACGTGTATGA GACAGACTAT TACCGCAAGG GTGGGAAGGG GCTGCTGCCC 3480
GTGCGCTGGA TGGCCCCGGA GTCCCTCAAA GATGGGATCT TCACCACCCA CTCGGATGTC 3540
TGGTCCTTCG GCGTGGTACT CTGGGAGATT GTGACCCTGG CTGAACAACC CTACCAGGGC 3600
CTGTCCAACG AGCAGGTGCT CAAGTTCGTC ATGGATGGTG GGGTCCTGGA GGAGCTGGAA 3660
GGCTGTCCCC TTCAGCTGCA GGAGCTGATG AGCCGCTGCT GGCAGCCAAA CCCGCGCCTG 3720
CGCCCAGCTT TCACGCACAT TCTGGACAGC ATACAGGAGG AGCTGCAGCC CTCCTTCCGC 3780
CACCTCTCTT TCTACTACAG CCCGGAG 3807
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+a+++++gee t+va+ktvne as rerieflkeasvmk+fk
Q: 984   ISIIRELGQGSFGMVYEGLAQGLEAGEEPTPVALKTVNELASPRERIEFLKEASVMKAFK  1043
         6799********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal ++iqma+e
Q: 1044  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALREMIQMAGE  1103
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw
Q: 1104  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1163
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e cp
Q: 1164  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCP  1223
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
          +l+elm++cwq np+lrp+f++i++++
Q: 1224  LQLQELMSRCWQPNPRLRPAFTHILDSI  1251
         ************************9976
Domain Sequence
(FASTA)
ISIIRELGQG SFGMVYEGLA QGLEAGEEPT PVALKTVNEL ASPRERIEFL KEASVMKAFK 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPQPA LREMIQMAGE 120
IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180
MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELEGCP 240
LQLQELMSRC WQPNPRLRPA FTHILDSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00014
EKS-ANC-00014
EKS-BOT-00016
EKS-CAF-00018
EKS-CAP-00017
EKS-EQC-00019
EKS-FEC-00017
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-LOA-00016
EKS-MAM-00017
EKS-MEG-00015
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-MYL-00019
EKS-NOL-00017
EKS-ORN-00025
EKS-ORC-00016
EKS-ORL-00021
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-POA-00017
EKS-RAN-00018
EKS-SAH-00015
EKS-SUS-00014
EKS-TAR-00024
EKS-XET-00017
EKS-XIM-00023
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013