EKS-CAJ-00179

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00179

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	433.8	5.4E-130	349	603	255

Status

Unreviewed

Ensembl Protein

ENSCJAP00000013396

UniProt Accession

F6ZHC0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000007197	ENSCJAP00000013396	ENSCJAT00000014113
ENSCJAG00000007197	ENSCJAP00000013474	ENSCJAT00000014194
ENSCJAG00000007197	ENSCJAP00000013477	ENSCJAT00000014197

Organism

Callithrix jacchus

Functional Description

Protein Length

676

Protein Sequence
(FASTA)

MPPFLRISFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60

AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120

FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240

PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVSQRASR 300

RSDSASSEPV GIYQGFEKKT GVSGEDSLDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF 360

GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK 420

DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIICG LQFLHSKGII YRDLKLDNVL 480

LDRDGHIKIA DFGMCKENIF GENRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE 540

MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFERDPPKR LGVTGNIKIH 600

PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF 660

AGFSFVNPKF EHLLED 676

Nucleotide Sequence
(FASTA)

ATGCCGCCAT TCCTGCGCAT CTCCTTCAAC TCCTACGAGC TGGGCTCCCT GCAGGCCGAG 60

GATGAGGCGA ACCAGCCCTT CTGTGCCGTG AAGATGAAGG AGGCACTCAG CACAGAGCGT 120

GGGAAAACAC TGGTGCAGAA GAAGCCGACC ATGTATCCTG AGTGGAAGTC AACATTTGAC 180

GCCCACATTT ACGAGGGCCG CGTCATCCAG ATTGTGCTAA TGCGGGCAGC CGAGGAGCCT 240

GTGTCTGAGG TGACCGTGGG TGTGTCGGTG CTGGCCGAGC GCTGCAAGAA GAACAACGGG 300

AAGGCCGAGT TCTGGCTGGA CCTGCAGCCC CAGGCCAAGG TGTTGATGTC TGTGCAGTAT 360

TTCCTGGAGG ACGTGGATTG CAAACAGTCT ATGCGTAGTG AGGACGAGGC CAAGTTCCCA 420

ACGATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCATGAG 480

TTTATCGCCA CCTTCTTTGG GCAACCCACC TTCTGTTCTG TGTGCAAAGA CTTTGTCTGG 540

GGCCTCAACA AGCAAGGCTA CAAATGCAGG CAATGTAACG CTGCCATCCA CAAGAAATGC 600

ATCGACAAGA TCATCGGCAG ATGCACTGGC ACTGCGGCCA ACAGCCGGGA CACCATATTC 660

CAGAAAGAAC GCTTCAACAT CGACATGCCT CACCGCTTCA AGGTTTACAA CTACATGAGC 720

CCCACCTTCT GCGACCACTG TGGCAGCCTG CTCTGGGGAT TGGTGAAGCA GGGATTAAAG 780

TGTGAAGACT GCGGCATGAA TGTGCACCAT AAGTGCCGGG AGAAGGTGGC CAACCTCTGC 840

GGCATCAACC AGAAGCTCTT GGCCGAGGCC TTGAACCAAG TCTCCCAGAG AGCCTCCCGG 900

AGATCAGACT CAGCCTCCTC AGAGCCTGTT GGGATATACC AGGGTTTCGA GAAGAAGACT 960

GGAGTCTCTG GGGAGGACTC ACTAGACAAC AGTGGGACCT ACGGCAAGAT CTGGGAGGGC 1020

AGCAGCAAGT GCAACATCAA CAACTTCATC TTCCACAAGG TCCTGGGCAA AGGCAGCTTC 1080

GGGAAGGTGC TGCTTGGAGA GCTGAAGGGC AGGGGAGAGT ACTTTGCCAT CAAGGCCCTC 1140

AAGAAGGATG TGGTGCTGAT CGATGACGAT GTGGAATGCA CCATGGTAGA GAAGCGGGTG 1200

CTGACGCTCG CCGCGGAGAA CCCCTTTCTC ACGCACCTCA TCTGTACCTT CCAGACCAAG 1260

GACCACCTGT TCTTTGTGAT GGAGTTCCTC AATGGGGGGG ACCTGATGTA CCACATCCAG 1320

GACAAAGGCC GCTTTGAACT CTACCGTGCC ACGTTTTATG CAGCGGAGAT CATCTGTGGA 1380

CTGCAGTTTC TACACAGCAA GGGCATCATT TATAGGGACC TCAAACTGGA CAATGTGCTG 1440

CTGGACCGGG ATGGCCACAT CAAGATTGCT GACTTTGGGA TGTGCAAAGA GAACATATTC 1500

GGGGAGAACC GGGCCAGCAC CTTCTGTGGC ACCCCTGACT ACATTGCCCC TGAGATCCTA 1560

CAGGGCCTGA AGTACACATT CTCTGTGGAC TGGTGGTCTT TTGGGGTCCT TCTCTACGAG 1620

ATGCTCATTG GCCAGTCCCC CTTCCATGGT GACGATGAGG ATGAACTCTT TGAGTCCATC 1680

CGTGTGGACA CGCCGCATTA TCCCCGCTGG ATCACCAAGG AGTCCAAGGA CATCCTGGAG 1740

AAGCTCTTTG AAAGGGACCC ACCCAAGAGG CTCGGAGTGA CCGGAAATAT CAAAATCCAT 1800

CCCTTCTTCA AGACCATAAA CTGGACTCTG CTGGAAAAGC GGAGGTTGGA GCCGCCCTTC 1860

AGGCCCAAAG TGAAGTCCCC CAGAGACTAC AGCAACTTCG ACCAAGAGTT CCTGAACGAG 1920

AAGGCACGCC TCTCCTACAG CGACAAGAAC CTCATTGACT CCATGGACCA GTCGGCCTTT 1980

GCCGGCTTCT CCTTTGTGAA CCCCAAATTT GAGCACCTCC TGGAAGATTG A 2031

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkvll elk++ e++aik lkkdvvl dddve+t+vekrvl+la+++p

Q: 349   FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP  408

         889*********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaeii++l+flh+kg

Q: 409   FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIICGLQFLHSKG  468

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld++Ghik+adfG+cke+i+ ++++stfcGtPdyiaPeil++ +y++s

Q: 469   IIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYTFS  528

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++l+++dp

Q: 529   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERDPP  588

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  +ik h+ff

Q: 589   KRLGV--TG--NIKIHPFF  603

         *****..56..79999998

Domain Sequence
(FASTA)

FIFHKVLGKG SFGKVLLGEL KGRGEYFAIK ALKKDVVLID DDVECTMVEK RVLTLAAENP 60

FLTHLICTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEII CGLQFLHSKG 120

IIYRDLKLDN VLLDRDGHIK IADFGMCKEN IFGENRASTF CGTPDYIAPE ILQGLKYTFS 180

VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLFERDPP 240

KRLGVTGNIK IHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013