EKS-CAJ-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	404.3	4.0E-121	259	514	256

Status

Unreviewed

Ensembl Protein

ENSCJAP00000042068

UniProt Accession

F7HKA8;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK

Gene Synonyms/Alias

MYLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000007474	ENSCJAP00000014097	ENSCJAT00000014852
ENSCJAG00000007474	ENSCJAP00000050745	ENSCJAT00000061270
ENSCJAG00000007474	ENSCJAP00000014088	ENSCJAT00000014843
ENSCJAG00000007474	ENSCJAP00000013968	ENSCJAT00000014715
ENSCJAG00000007474	ENSCJAP00000045979	ENSCJAT00000057613
ENSCJAG00000007474	ENSCJAP00000014081	ENSCJAT00000014835
ENSCJAG00000007474	ENSCJAP00000014101	ENSCJAT00000014857
ENSCJAG00000007474	ENSCJAP00000014072	ENSCJAT00000014825
ENSCJAG00000007474	ENSCJAP00000014075	ENSCJAT00000014828
ENSCJAG00000007474	ENSCJAP00000042068	ENSCJAT00000062146

Organism

Callithrix jacchus

Functional Description

Protein Length

636

Protein Sequence
(FASTA)

PKEACDPWIY TKGDATVKKK PAPKTPPKAA MPPQIIQFPE DQKVRAGESV ELFGKVAGTQ 60

PITCTWMKFR KQIQESEHMK VENSENGSKL TILAARQEHC GCYTLLVENK LGSRQAQVNL 120

TVVDKPDPPA GTPCASDIRS SSLTLSWYGS SYDGGSAVQS YSIEIWDSAN KTWKELATCR 180

STSFNVQDLL PDHEYKFRVR AINVYGTSEP SQESELTRVG EKPEEPKDEV EVSDDDEKEP 240

EVDYRTVTVN TEQKVSDFYD IEERLGSGKF GQVFRLVEKK TRKVWAGKFF KAYSAKEKEN 300

IRQEISIMNC LHHPKLVQCV DAFEEKANIV MVLEIVSGGE LFERIIDEDF ELTERECIKY 360

MRQISEGVEY IHKQGIVHLD LKPENIMCVN KTGTRIKLID FGLARRLENA GSLKVLFGTP 420

EFVAPEVINY EPIGYATDMW SIGVICYILV SGLSPFMGDN DNETLANVTS ATWDFDDEAF 480

DEISDDAKDF ISSLLKKDMK NRLDCTQCLQ HPWLMKDTKN MEAKKLSKDR MKKYMARRKW 540

QKTGNAVRAI GRLSSMAMIS GLSGRKASTG SPTSPLNAEK LESEEDVSQA FLEAVAEEKP 600

HVKPYFSKTI RDLEVVEGSA ARFDCKIEGY PDPEVV 636

Nucleotide Sequence
(FASTA)

CCAAAGGAAG CTTGCGACCC TTGGATCTAC ACCAAAGGTG ATGCAACTGT GAAAAAGAAA 60

CCTGCCCCTA AGACGCCTCC GAAGGCAGCA ATGCCCCCTC AGATCATCCA GTTTCCTGAG 120

GACCAGAAGG TCCGTGCAGG AGAGTCAGTG GAGCTGTTTG GAAAAGTGGC TGGCACGCAG 180

CCCATCACCT GTACCTGGAT GAAGTTCCGA AAGCAGATCC AGGAGAGCGA GCACATGAAG 240

GTGGAGAACA GCGAGAATGG CAGCAAGCTC ACCATCCTGG CTGCGCGCCA GGAGCACTGC 300

GGCTGCTACA CACTGCTGGT GGAGAACAAG CTGGGCAGCA GGCAGGCCCA GGTCAACCTC 360

ACTGTCGTGG ATAAGCCAGA TCCCCCCGCT GGCACACCTT GTGCCTCTGA CATTCGGAGC 420

TCCTCGCTGA CCCTGTCCTG GTATGGCTCC TCGTATGATG GGGGCAGTGC CGTACAGTCC 480

TACAGCATCG AGATCTGGGA CTCAGCCAAC AAGACATGGA AGGAACTAGC CACATGCCGC 540

AGCACCTCTT TCAACGTCCA GGACCTACTG CCTGACCACG AGTACAAATT CCGTGTACGT 600

GCAATCAACG TGTATGGTAC CAGTGAGCCA AGCCAGGAGT CTGAACTCAC AAGAGTAGGA 660

GAGAAACCCG AAGAGCCGAA GGATGAAGTG GAAGTGTCAG ACGATGATGA GAAGGAGCCT 720

GAGGTTGATT ACCGGACGGT GACAGTCAAT ACCGAACAAA AAGTATCTGA CTTCTATGAC 780

ATTGAAGAGA GATTAGGATC TGGGAAATTT GGACAGGTCT TTCGACTTGT AGAAAAGAAA 840

ACTCGAAAAG TCTGGGCAGG GAAATTCTTC AAAGCATATT CAGCAAAAGA GAAAGAGAAT 900

ATCCGACAGG AGATCAGCAT TATGAACTGC CTCCACCACC CCAAGCTGGT CCAGTGTGTG 960

GATGCCTTCG AAGAAAAGGC CAACATAGTC ATGGTCCTGG AGATCGTGTC AGGGGGTGAG 1020

CTGTTTGAGC GCATCATTGA CGAGGACTTC GAGCTGACGG AGCGCGAGTG CATCAAGTAC 1080

ATGCGGCAGA TCTCGGAGGG GGTGGAGTAC ATCCACAAGC AGGGCATCGT GCACCTGGAC 1140

CTCAAGCCCG AGAATATCAT GTGTGTCAAC AAGACAGGCA CCAGGATCAA GCTCATTGAC 1200

TTTGGTCTGG CCAGGAGACT GGAGAATGCG GGGTCTCTGA AGGTCCTCTT TGGCACTCCG 1260

GAGTTTGTGG CTCCTGAAGT GATCAACTAT GAGCCCATTG GCTACGCCAC AGACATGTGG 1320

AGCATCGGGG TCATCTGCTA CATCCTGGTC AGTGGCCTTT CCCCCTTCAT GGGAGACAAC 1380

GATAATGAAA CCTTGGCCAA CGTTACCTCA GCCACCTGGG ACTTCGACGA CGAGGCATTC 1440

GATGAGATCT CCGATGATGC CAAGGATTTC ATCAGCAGTC TGCTGAAGAA AGATATGAAA 1500

AACCGCCTGG ACTGCACGCA GTGCCTTCAG CATCCATGGC TAATGAAAGA TACCAAGAAC 1560

ATGGAGGCCA AGAAACTCTC CAAGGACCGG ATGAAGAAGT ACATGGCAAG AAGGAAATGG 1620

CAGAAAACGG GCAATGCTGT GAGAGCCATT GGAAGGCTGT CCTCTATGGC AATGATCTCG 1680

GGGCTCAGTG GCAGGAAAGC CTCAACAGGG TCACCAACCA GCCCACTCAA CGCAGAAAAA 1740

CTAGAATCTG AAGAAGATGT GTCCCAAGCT TTCCTTGAGG CCGTTGCTGA GGAAAAGCCC 1800

CACGTAAAAC CCTATTTCTC TAAGACCATT CGTGATTTAG AAGTTGTGGA GGGAAGTGCT 1860

GCTAGATTTG ACTGCAAGAT TGAAGGCTAC CCGGACCCCG AGGTTGTC 1908

Domain Profile

S: 1     ysikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliq  60

         y+i+e+lg+Gkfg+v++ vek+t+k++a+k++k+ ++k+ke++++Ei+i+n+l+H+kl+q

Q: 259   YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQ  318

         899*********************************************************

S: 61    lydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivH  120

         ++dafe+k++iv+vlE+v+ggelferi++ed+eltE+e+++++rq++e++ey+Hk+givH

Q: 319   CVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVH  378

         ************************************************************

S: 121   ldlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatD  180

         ldlkpeni++++k++++iKlidFGlar+l+++ +lkvlfgtpefvaPEv+n+ep+++atD

Q: 379   LDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATD  438

         ************************************************************

S: 181   mWsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvke  240

         mWs+Gvi+y+L+sGlsPF+gdnd+etl+nv+sa++dfd+eaf+e+s++akdFis ll+k+

Q: 439   MWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISSLLKKD  498

         ************************************************************

S: 241   kkkRmsaeeaLkhkwl  256

         +k+R++++++L+h+wl

Q: 499   MKNRLDCTQCLQHPWL  514

         ***************8

Domain Sequence
(FASTA)

YDIEERLGSG KFGQVFRLVE KKTRKVWAGK FFKAYSAKEK ENIRQEISIM NCLHHPKLVQ 60

CVDAFEEKAN IVMVLEIVSG GELFERIIDE DFELTERECI KYMRQISEGV EYIHKQGIVH 120

LDLKPENIMC VNKTGTRIKL IDFGLARRLE NAGSLKVLFG TPEFVAPEVI NYEPIGYATD 180

MWSIGVICYI LVSGLSPFMG DNDNETLANV TSATWDFDDE AFDEISDDAK DFISSLLKKD 240

MKNRLDCTQC LQHPWL 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 9.
PF00069	; Pkinase; 1.

SMARTs

SM00060	; FN3; 1.
SM00409	; IG; 1.
SM00408	; IGc2; 8.
SM00220	; S_TKc; 1.

Prosites

PS50853	; FN3; 1.
PS50835	; IG_LIKE; 9.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013