EKS-CAJ-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CASK	542.1	4.3E-163	12	276	265

Status

Unreviewed

Ensembl Protein

ENSCJAP00000016537

UniProt Accession

F7BPU5;

Protein Name

Protein Synonyms/Alias

Gene Name

CASK

Gene Synonyms/Alias

CASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000008892	ENSCJAP00000016470	ENSCJAT00000017416
ENSCJAG00000008892	ENSCJAP00000016537	ENSCJAT00000017486

Organism

Callithrix jacchus

Functional Description

Protein Length

897

Protein Sequence
(FASTA)

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60

REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120

YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180

GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240

QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300

RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE IHALTDCSEK 360

DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP QIRNPPSDAV QRAKEVLEEI SCYPENNDAK 420

ELKRILTQPH FMALLQTHDV VAHEVYSDEA LRVTPPPTSP YLNGDSPESA NGDMDMENVT 480

RVRLVQFQKN TDEPMGITLK MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN 540

QTVEQLQKML REMRGSITFK IVPSYRTQSS SCEDLPSTTQ PKGRQIYVRA QFEYDPAKDD 600

LIPCKEAGIR FRVGDIIQII SKDDHNWWQG KLENSKNGTA GLIPSPELQE WRVACIAMEK 660

TKQEQQASCT WFGKKKKQYK DKYLAKHNAV FDQLDLVTYE EVVKLPAFKR KTLVLLGAHG 720

VGRRHIKNTL ITKHPDRFAY PIPHTTRPPK KDEENGKNYY FVSHDQMMQD ISNNEYLEYG 780

SHEDAMYGTK LETIRKIHEQ GLIAILDVEP QALKVLRTAE FAPFVVFIAA PTITPGLNED 840

ESLQRLQKES DILQRTYAHY FDLTIINNEI DETIRHLEEA VELVCTAPQW VPVSWVY 897

Nucleotide Sequence
(FASTA)

ATGGCCGACG ACGACGTGCT GTTCGAGGAT GTGTACGAGC TGTGCGAGGT GATCGGCAAG 60

GGTCCCTTCA GTGTTGTACG ACGATGTATC AACAGAGAAA CTGGACAACA ATTTGCTGTA 120

AAAATTGTTG ATGTAGCCAA GTTCACATCA AGTCCAGGGT TAAGTACAGA AGATCTAAAG 180

CGGGAAGCCA GTATCTGTCA TATGCTGAAA CATCCACACA TTGTAGAGTT ATTGGAGACA 240

TATAGCTCAG ATGGAATGCT TTACATGGTT TTCGAATTTA TGGATGGAGC AGATCTGTGT 300

TTTGAAATCG TAAAGCGAGC TGATGCTGGT TTTGTGTACA GTGAAGCTGT AGCCAGCCAT 360

TACATGAGAC AGATACTGGA AGCTCTACGC TACTGTCATG ACAATAACAT AATTCACAGG 420

GATGTGAAGC CCCACTGTGT TCTCCTCGCC TCAAAAGAAA ACTCGGCACC TGTTAAACTT 480

GGGGGCTTTG GGGTAGCTAT TCAATTAGGG GAGTCTGGAC TTGTAGCTGG AGGACGTGTT 540

GGAACACCTC ATTTTATGGC ACCAGAAGTG GTCAAAAGAG AGCCTTACGG AAAGCCTGTA 600

GACGTCTGGG GGTGCGGTGT GATCCTTTTT ATCCTGCTCA GTGGTTGTTT GCCTTTTTAC 660

GGAACCAAGG AAAGATTGTT TGAAGGAATT ATTAAAGGAA AATATAAGAT GAATCCAAGG 720

CAGTGGAGCC ATATCTCTGA AAGTGCCAAA GACCTAGTAC GTCGCATGCT GATGCTGGAT 780

CCAGCTGAAA GGATCACCGT TTATGAAGCA CTGAATCACC CATGGCTTAA GGAGCGGGAT 840

CGTTATGCCT ACAAGATTCA TCTTCCAGAA ACAGTAGAGC AGCTGAGGAA GTTCAATGCA 900

AGGAGGAAAC TAAAGGGCGC AGTACTAGCC GCTGTGTCAA GTCACAAATT CAACTCATTC 960

TACGGGGATC CCCCTGAAGA GTTACCAGAT TTCTCTGAAG ACCCTACCTC CTCAGGAGCA 1020

GTCTCACAGG TGCTGGACAG CCTGGAAGAG ATTCACGCAC TTACAGACTG CAGTGAAAAA 1080

GACCTAGATT TTCTACACAG TGTTTTCCAG GATCAGCATC TTCACACACT ACTAGATCTG 1140

TATGACAAAA TTAACACAAA GTCTTCACCA CAAATCAGGA ATCCACCAAG CGATGCAGTA 1200

CAGAGAGCCA AAGAGGTTTT GGAAGAAATT TCATGTTACC CTGAGAATAA TGATGCAAAG 1260

GAACTAAAGC GTATTTTAAC ACAACCTCAT TTCATGGCCT TACTTCAGAC TCACGACGTA 1320

GTGGCACATG AAGTTTACAG TGATGAAGCA TTGAGGGTCA CACCTCCTCC CACCTCTCCC 1380

TATTTAAACG GCGATTCTCC AGAAAGTGCT AACGGAGACA TGGATATGGA GAATGTGACC 1440

AGAGTTCGGC TGGTACAGTT CCAAAAGAAC ACAGATGAAC CAATGGGAAT CACTTTAAAA 1500

ATGAATGAAC TAAATCATTG TATTGTTGCA AGAATTATGC ATGGGGGCAT GATTCACAGG 1560

CAAGGTACAC TTCATGTTGG TGATGAAATT CGAGAAATCA ATGGCATCAG TGTGGCTAAC 1620

CAAACAGTGG AACAGCTGCA AAAAATGCTT AGGGAAATGC GGGGGAGTAT TACCTTCAAG 1680

ATTGTGCCAA GTTACCGCAC TCAGTCTTCG TCCTGTGAGG ACTTGCCATC AACTACCCAA 1740

CCAAAAGGAC GACAGATCTA TGTAAGAGCT CAATTTGAAT ATGATCCAGC CAAGGATGAC 1800

CTCATCCCCT GCAAAGAAGC TGGCATTCGA TTCAGAGTTG GTGACATCAT CCAGATTATT 1860

AGTAAGGATG ATCATAATTG GTGGCAGGGT AAACTGGAAA ACTCCAAAAA CGGAACTGCA 1920

GGTCTCATTC CTTCTCCTGA ACTTCAGGAA TGGCGAGTAG CTTGCATTGC CATGGAGAAG 1980

ACCAAACAGG AGCAGCAGGC CAGCTGTACT TGGTTTGGCA AGAAAAAGAA GCAGTACAAA 2040

GATAAATATT TGGCAAAGCA CAATGCAGTG TTTGATCAAT TAGATCTTGT CACATATGAA 2100

GAAGTAGTAA AACTGCCAGC ATTCAAAAGG AAAACATTAG TCTTATTAGG CGCACATGGT 2160

GTTGGGAGAA GACACATAAA AAACACTCTC ATCACAAAGC ACCCAGACCG GTTTGCGTAC 2220

CCTATTCCAC ATACAACCAG ACCTCCAAAG AAAGATGAAG AAAATGGAAA GAATTATTAC 2280

TTTGTATCTC ATGACCAAAT GATGCAAGAC ATCTCTAATA ACGAGTACTT GGAATATGGC 2340

AGCCACGAGG ATGCGATGTA TGGGACAAAA CTGGAGACCA TCCGGAAGAT CCATGAGCAG 2400

GGGCTGATTG CAATACTGGA TGTGGAGCCT CAGGCACTGA AGGTCCTGAG AACTGCAGAG 2460

TTCGCTCCTT TTGTTGTTTT CATTGCTGCC CCAACTATTA CTCCAGGTTT AAATGAGGAT 2520

GAATCTCTTC AGCGTCTGCA GAAGGAGTCT GACATCTTAC AGAGAACATA TGCACACTAC 2580

TTCGATCTCA CAATTATCAA CAATGAAATT GATGAGACAA TCAGACATCT GGAGGAAGCT 2640

GTTGAGCTCG TGTGCACAGC CCCACAGTGG GTCCCTGTCT CCTGGGTCTA TTAG 2694

Domain Profile

S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60

         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh

Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71

         89**********************************************************

S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120

         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry

Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131

         ************************************************************

S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180

         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev

Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190

         ****************************************.*******************

S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240

         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak

Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250

         ************************************************************

S: 241   dlvrrmlaadpakrisvkealnhewl  266

         dlvrrml++dpa+ri+v+ealnh+wl

Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276

         *************************7

Domain Sequence
(FASTA)

YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60

PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120

CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180

KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240

LVRRMLMLDP AERITVYEAL NHPWL 265

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008144	; Guanylate_kin.
IPR008145	; Guanylate_kin/L-typ_Ca_channel.
IPR020590	; Guanylate_kinase_CS.
IPR011009	; Kinase-like_dom.
IPR004172	; L27.
IPR014775	; L27_C.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.

Pfam

PF00625	; Guanylate_kin; 1.
PF02828	; L27; 2.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00072	; GuKc; 1.
SM00569	; L27; 2.
SM00228	; PDZ; 1.
SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00856	; GUANYLATE_KINASE_1; 1.
PS50052	; GUANYLATE_KINASE_2; 1.
PS51022	; L27; 2.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013