EKS-CAJ-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	507.8	1.8E-152	703	1008	306

Status

Unreviewed

Ensembl Protein

ENSCJAP00000016865

UniProt Accession

F6WQH6;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000009197	ENSCJAP00000049986	ENSCJAT00000063441
ENSCJAG00000009197	ENSCJAP00000016865	ENSCJAT00000017833

Organism

Callithrix jacchus

Functional Description

Protein Length

1128

Protein Sequence
(FASTA)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LKEIRESLRN LSKPSDATKA EHNMSKMSTE 60

DPRQVRNPPK FGTHHKVLQE IRNSLLPFAN ETNSRSTSEV NPQMLQDLQA AGFDEDMVIQ 120

ALQKTNNRSI EAAIEFISKM SYQDPRREQM AAAAARPVNA SMKPGNVQQS VNRKQSWKGS 180

KESLVPQRHG PPLGESVAYH SESPSSQADV GRPLSGSGIT AFAQAHPSNG QRVNPLPPPQ 240

VRSVTPPPPP RGQTPPPRGT TPPPPSWEPN SQTKRYSGNM EYVISRISPV PPGTWQEGYP 300

PPPLNTSPMN PPNQGQRGIS SVPVGRQPII MQSSSKFNFP SGRPGMQNGT GQTDFMIHQN 360

VPAGTVNRQP PPPYPLTAAN GQSPSALQTG GSAAPSSYIN GNIPQSMMVP NRNSHNMELY 420

NINVPGLQTN WPQSSSAPAQ SSPSSGHEIP TWQPNIPVRS NSFNNPLGNR ASHSANSQPS 480

ATTVTAITPA PIQQPVKSMR VLKPELQTAL APTHPSWIPQ PIQTVQPSPF SEGTTSNVTV 540

MPPVAEAPNY QGPPPPYPKH LLHQNPSVPP YESISKPSKE DQPSLPKEDE SEKSYENVDS 600

GDKEKKQITT SPITVRKNKK DEERRESRIQ SYSPQAFKFF MEQHVENVLK SHQQRLHRKK 660

QLENEMMRVG LSQDAQDQMR KMLCQKESNY IRLKRAKMDK SMFVKIKTLG VGAFGEVCLA 720

RKVDTKALYA TKTLRKKDVL LRNQVAHVKA ERDILAEADN EWVVRLYYSF QDKDNLYFVM 780

DYIPGGDMMS LLIRMGIFPE NLARFYIAEL TCAVESVHKM GFIHRDIKPD NILIDRDGHI 840

KLTDFGLCTG FRWTHDSKYY QSGDHPRQDS MDFSNEWGDP SSCRCGDRLK PLERRAARQH 900

QRCLAHSLVG TPNYIAPEVL LRTGYTQLCD WWSVGVILFE MLVGQPPFLA QTPLETQMKV 960

INWQTSLHIP PQAKLSPEAS DLIIKLCRGP EDRLGKNGAD EIKAHPFFKT IDFSSDLRQQ 1020

SASYIPKITH PTDTSNFDPV DPDKLWSDDT EEENVNDTLN GWYKNGKHPE HAFYEFTFRR 1080

FFDDNGYPYN YPKPIEYEYI NSQGSEQQSD EDDQHTGSEI KNRDLVYV 1128

Nucleotide Sequence
(FASTA)

ATGAAGAGGA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60

AGTAACTATA CTGGCAGTAG CCGACAAATG TTAAAAGAAA TTCGGGAATC CCTTAGGAAT 120

TTATCTAAAC CATCAGATGC TACTAAGGCT GAGCATAACA TGAGTAAAAT GTCAACTGAA 180

GATCCTCGAC AAGTCAGAAA TCCACCCAAA TTTGGGACAC ATCATAAAGT CTTGCAGGAA 240

ATTCGAAATT CTCTGCTTCC ATTTGCAAAT GAAACAAATT CTCGTAGTAC TTCAGAAGTT 300

AATCCACAAA TGCTTCAAGA CTTACAAGCT GCTGGATTTG ATGAGGATAT GGTTATACAA 360

GCTCTTCAGA AAACAAACAA CAGAAGTATA GAAGCAGCAA TTGAATTCAT TAGTAAAATG 420

AGTTACCAAG ATCCACGACG AGAGCAGATG GCTGCGGCAG CTGCCAGACC TGTTAATGCC 480

AGCATGAAAC CAGGGAATGT GCAACAATCA GTTAACCGCA AACAGAGCTG GAAAGGTTCT 540

AAAGAATCCT TAGTTCCTCA GAGACATGGC CCACCACTAG GAGAAAGTGT GGCCTATCAT 600

TCTGAGAGTC CCAGCTCACA GGCAGATGTA GGAAGACCTT TGTCTGGATC TGGTATAACA 660

GCATTTGCTC AAGCTCACCC TAGCAATGGA CAGAGAGTGA ACCCCCTACC ACCACCTCAA 720

GTAAGGAGTG TCACTCCTCC ACCACCTCCA AGAGGCCAGA CTCCCCCTCC AAGAGGTACA 780

ACTCCACCTC CTCCTTCATG GGAACCAAAC TCTCAAACAA AGCGCTATTC TGGGAACATG 840

GAATACGTAA TCTCCCGAAT CTCTCCTGTC CCACCTGGGA CATGGCAAGA GGGCTATCCA 900

CCACCACCTC TCAACACTTC CCCCATGAAT CCTCCTAATC AGGGACAGAG AGGCATTAGT 960

TCTGTTCCTG TTGGCAGACA ACCAATCATC ATGCAGAGTT CTAGCAAATT TAACTTTCCA 1020

TCAGGGAGAC CTGGAATGCA GAATGGTACT GGACAGACTG ATTTCATGAT ACACCAAAAT 1080

GTCCCTGCTG GCACTGTGAA TCGGCAGCCG CCACCTCCAT ATCCTCTGAC CGCAGCTAAT 1140

GGACAAAGCC CTTCTGCTTT ACAGACAGGG GGATCTGCTG CTCCTTCATC ATATATAAAT 1200

GGAAATATTC CTCAGTCTAT GATGGTGCCA AACAGAAATA GTCATAACAT GGAACTGTAT 1260

AACATTAATG TGCCGGGACT GCAAACAAAT TGGCCTCAGT CATCCTCTGC TCCAGCCCAG 1320

TCGTCCCCAA GCAGTGGGCA TGAAATCCCT ACCTGGCAAC CTAACATACC AGTGAGGTCA 1380

AATTCTTTTA ACAACCCATT GGGAAATAGA GCAAGTCACT CTGCTAATTC TCAGCCTTCT 1440

GCTACAACAG TCACTGCAAT TACACCAGCT CCTATTCAAC AGCCTGTGAA AAGCATGCGT 1500

GTATTAAAAC CAGAGCTACA GACTGCTTTA GCACCTACAC ACCCTTCTTG GATACCACAG 1560

CCAATTCAAA CTGTTCAACC CAGTCCTTTT TCTGAGGGAA CCACGTCAAA TGTGACTGTG 1620

ATGCCACCTG TTGCTGAAGC TCCAAATTAT CAAGGACCAC CACCACCCTA CCCAAAACAT 1680

CTGCTGCACC AAAACCCATC TGTTCCTCCA TATGAATCAA TCAGTAAGCC TAGCAAAGAG 1740

GATCAGCCAA GCTTGCCCAA GGAGGATGAG AGTGAAAAGA GTTATGAAAA TGTTGATAGT 1800

GGGGATAAAG AAAAGAAACA AATTACAACT TCACCCATCA CTGTTAGGAA AAACAAGAAA 1860

GATGAAGAGC GAAGGGAATC TCGTATTCAA AGTTACTCTC CTCAAGCATT TAAATTCTTT 1920

ATGGAGCAAC ATGTGGAAAA TGTACTGAAA TCTCATCAGC AGCGTCTACA TCGTAAAAAA 1980

CAATTAGAGA ATGAAATGAT GCGGGTTGGA TTATCTCAGG ATGCCCAGGA TCAAATGAGA 2040

AAGATGCTTT GCCAAAAAGA ATCTAATTAC ATTCGTCTTA AAAGGGCTAA AATGGACAAG 2100

TCTATGTTTG TGAAGATAAA GACACTAGGA GTAGGAGCAT TTGGTGAAGT CTGTCTAGCA 2160

AGAAAAGTAG ATACTAAGGC TTTGTATGCA ACAAAAACTC TTCGAAAGAA AGATGTTCTG 2220

CTTCGAAATC AAGTCGCTCA TGTTAAAGCT GAGAGAGATA TCCTGGCTGA AGCTGACAAT 2280

GAATGGGTGG TTCGCCTATA TTATTCATTC CAAGATAAAG ACAATTTATA TTTTGTAATG 2340

GACTACATTC CTGGGGGTGA TATGATGAGC CTATTAATTA GAATGGGCAT CTTTCCAGAA 2400

AACCTGGCAC GATTCTACAT AGCAGAACTT ACCTGTGCAG TTGAAAGTGT TCATAAAATG 2460

GGTTTTATTC ATAGAGATAT TAAACCCGAT AATATTTTGA TTGATCGTGA TGGTCATATT 2520

AAATTGACTG ACTTTGGCCT CTGCACTGGC TTCAGATGGA CACACGATTC TAAGTACTAT 2580

CAGAGTGGTG ACCATCCAAG GCAAGATAGC ATGGATTTCA GTAATGAGTG GGGGGATCCC 2640

TCAAGCTGTC GATGTGGAGA CAGACTGAAG CCGTTAGAGC GGAGAGCTGC ACGCCAGCAC 2700

CAGCGATGTC TAGCACATTC TTTGGTTGGG ACTCCCAATT ATATTGCACC TGAAGTGTTG 2760

CTACGAACAG GATACACACA GTTATGTGAT TGGTGGAGTG TTGGTGTTAT TCTTTTTGAA 2820

ATGTTGGTGG GACAACCTCC TTTCTTGGCA CAAACACCAT TAGAAACACA AATGAAGGTT 2880

ATCAACTGGC AAACATCTCT TCACATCCCA CCACAAGCTA AACTCAGTCC TGAAGCTTCT 2940

GACCTTATTA TTAAACTTTG CCGAGGACCT GAAGATCGCT TAGGCAAGAA TGGTGCTGAT 3000

GAAATAAAAG CTCATCCATT TTTTAAAACA ATTGATTTCT CCAGTGACCT GAGACAGCAG 3060

TCTGCTTCAT ACATTCCTAA AATCACACAC CCAACAGATA CATCAAATTT TGATCCTGTT 3120

GATCCTGATA AGTTATGGAG TGATGATACC GAGGAAGAAA ATGTAAATGA CACTCTCAAT 3180

GGATGGTATA AAAATGGAAA GCATCCTGAA CATGCATTCT ATGAATTTAC CTTCCGGAGA 3240

TTTTTTGATG ACAATGGCTA CCCATATAAT TATCCGAAGC CTATTGAATA TGAATACATT 3300

AATTCACAAG GCTCAGAGCA GCAGTCAGAT GAAGATGATC AACACACAGG CTCAGAGATT 3360

AAAAATCGAG ATCTAGTGTA TGTTTAA 3387

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 703   FVKIKTLGVGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  762

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 763   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  822

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+

Q: 823   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpss  882

         ***************************************************999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 883   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  942

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 943   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1002

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1003  KAHPFF  1008

         *****9

Domain Sequence
(FASTA)

FVKIKTLGVG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPSS 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013