EKS-CAJ-00378

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00378

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	385.0	3.0E-115	188	436	249

Status

Unreviewed

Ensembl Protein

ENSCJAP00000018910

UniProt Accession

F7H0I3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000010253	ENSCJAP00000018915	ENSCJAT00000019977
ENSCJAG00000010253	ENSCJAP00000018910	ENSCJAT00000019972

Organism

Callithrix jacchus

Functional Description

Protein Length

442

Protein Sequence
(FASTA)

PQPPCAAAPQ LFRALHDFRA RRGGELSVRH GDDLCALGED EGGCTLARRL SGQPSAGLVP 60

ITCVAEASPE LLSDQPWYFS GVSRTQAQEL LLSPPNEPGA FLVRPSESSL GGYSLSVRAQ 120

ASVCHYRVSM AADGSLYLQK GQLFPGLEEL LIYYKANWKL IQNPLLRPCV PQKPIQQDTW 180

ERPHSEFALR RKLGEGYFGE VWEGLWLGSL PVAIKIIKSA DMKLTDLAKE IQTLKGLRHK 240

RLIRLHAVCS AGEPVYIVTE LMGKGNLRAY LGSPEGRALC LSPLLGFACQ VAEGMSYLEE 300

RRIVHRDLAA RNVLVDDGLA CKVADFGLAR LLKDDIYSPS SGSKIPVKWT APEAANYHVF 360

SQKSDVWSFG VLLYEVFTYG QCPYEGMTNH ETLQQITRGY RLPRPATCPA EVYVLMLECW 420

RGSPEERPTF AMLWEKLHAI HR 442

Nucleotide Sequence
(FASTA)

CCGCAGCCCC CATGCGCCGC CGCGCCTCAG CTCTTCCGCG CGCTCCACGA CTTCAGGGCG 60

CGGCGCGGGG GGGAGCTGAG TGTCCGCCAC GGGGACGATC TCTGCGCCCT CGGGGAGGAT 120

GAGGGCGGCT GCACCCTTGC GCGCAGGCTC TCGGGCCAGC CCAGCGCGGG GCTCGTGCCC 180

ATCACCTGCG TTGCCGAGGC CTCTCCGGAG CTGCTCTCAG ACCAACCCTG GTACTTCAGT 240

GGGGTCAGCC GGACCCAGGC CCAGGAGCTG CTCCTCTCCC CACCCAACGA ACCAGGGGCT 300

TTCCTTGTCC GACCCAGCGA GAGCAGCCTC GGGGGCTACT CACTGTCAGT CCGGGCCCAG 360

GCCAGCGTCT GCCACTACCG GGTCTCCATG GCAGCTGACG GCAGCCTCTA TCTGCAGAAG 420

GGCCAGCTCT TTCCTGGCCT GGAGGAGCTG CTCATCTACT ACAAGGCCAA CTGGAAGCTG 480

ATCCAGAACC CGCTGCTGCG GCCCTGTGTG CCCCAGAAGC CCATACAGCA GGATACGTGG 540

GAGCGGCCAC ACTCTGAATT TGCCCTTCGG AGGAAGCTGG GTGAAGGCTA CTTCGGGGAG 600

GTGTGGGAAG GCCTGTGGCT GGGCTCCCTG CCCGTGGCGA TCAAGATCAT CAAGTCAGCC 660

GACATGAAGC TCACAGACCT CGCCAAGGAG ATCCAGACAC TGAAGGGTCT GCGGCACAAG 720

CGGCTCATCC GGCTGCATGC GGTGTGCTCG GCTGGGGAGC CAGTGTACAT TGTCACGGAG 780

CTCATGGGCA AGGGAAACCT GCGGGCCTAC CTGGGCAGCC CTGAAGGCCG GGCCCTGTGT 840

CTGTCGCCTC TGCTGGGCTT TGCCTGCCAG GTGGCGGAGG GCATGAGCTA CCTGGAGGAA 900

CGACGCATTG TGCACCGGGA CCTGGCTGCC AGGAACGTGC TTGTGGATGA TGGCCTGGCC 960

TGCAAGGTGG CTGACTTTGG CCTGGCCCGG CTGCTCAAGG ACGACATCTA CTCCCCAAGC 1020

AGCGGCTCCA AGATCCCGGT CAAGTGGACA GCGCCCGAGG CGGCCAATTA TCATGTCTTC 1080

TCCCAGAAGT CGGATGTCTG GTCCTTCGGT GTCCTGCTGT ACGAGGTTTT CACCTACGGC 1140

CAGTGTCCCT ATGAAGGAAT GACCAACCAC GAGACGCTGC AGCAGATCAC GCGAGGGTAC 1200

CGGCTGCCGC GCCCAGCCAC CTGCCCGGCG GAGGTCTACG TTCTCATGCT GGAGTGCTGG 1260

AGGGGCAGCC CTGAGGAGCG GCCCACCTTT GCCATGTTGT GGGAGAAGCT GCACGCCATC 1320

CACAGA 1326

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w gs++va+k +k+++++ +++ +e+q+lk lrh++l++l+a

Q: 188   ALRRKLGEGYFGEVWEGLWLGSLPVAIKIIKSADMKLTDLAKEIQTLKGLRHKRLIRLHA  247

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s++eP+yivtelm kG+l ++l + eg++l l+ l+ +a+qvaeGm+ylee++++hrd

Q: 248   VCSAGEPVYIVTELMGKGNLRAYLGSPEGRALCLSPLLGFACQVAEGMSYLEERRIVHRD  307

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlv++ l++kvadfGlarl++dd+y++++g+k+P+kWtaPea+++++f++ksdvW

Q: 308   LAARNVLVDDGLACKVADFGLARLLKDDIYSPSSGSKIPVKWTAPEAANYHVFSQKSDVW  367

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+Gmtn+e+l+q++rgyrlprp++cp+e+y l+lecw+ +peer

Q: 368   SFGVLLYEVFTYGQCPYEGMTNHETLQQITRGYRLPRPATCPAEVYVLMLECWRGSPEER  427

         ************************************************************

S: 242   Ptfetlqev  250

         Ptf +l e+

Q: 428   PTFAMLWEK  436

         ****99876

Domain Sequence
(FASTA)

ALRRKLGEGY FGEVWEGLWL GSLPVAIKII KSADMKLTDL AKEIQTLKGL RHKRLIRLHA 60

VCSAGEPVYI VTELMGKGNL RAYLGSPEGR ALCLSPLLGF ACQVAEGMSY LEERRIVHRD 120

LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSGSKIPV KWTAPEAANY HVFSQKSDVW 180

SFGVLLYEVF TYGQCPYEGM TNHETLQQIT RGYRLPRPAT CPAEVYVLML ECWRGSPEER 240

PTFAMLWEK 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013