EKS-CAJ-00198

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00198

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	472.4	7.7E-142	310	579	270

Status

Unreviewed

Ensembl Protein

ENSCJAP00000020232

UniProt Accession

F7ESW1;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000010908	ENSCJAP00000020243	ENSCJAT00000021387
ENSCJAG00000010908	ENSCJAP00000036833	ENSCJAT00000038900
ENSCJAG00000010908	ENSCJAP00000036825	ENSCJAT00000038891
ENSCJAG00000010908	ENSCJAP00000020232	ENSCJAT00000021375

Organism

Callithrix jacchus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MGSYLSVPAY FTSRDPFRCS ECQDSLTNWY YEKDGKLYCR KDYWGKFGEF CHGCSLLMTG 60

PFMVAGEFKY HPECFACMSC KVIIEDGDAY ALVQHATLYC GKCHNEVVLA PMFERLSTES 120

VQNQLPYSVT LISMPATTEG RRGFSVSVES ACSNYATTVQ VKEVNRMHIS PNNRNAIHPG 180

DRILEINGIP VRTLRVEEVE DAVSQTSQTL QLLIEHDPVS QRLDQLRLEA RLSPHMQNAE 240

HPHTLSTLDT KENLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLFSRDISR SESLRCSSSY 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVTHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

ILDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRGMD PFPWQQKVRF AKGIASGMAY 420

LHSMCIIHRD LNSHNCLIKL DKTVVVADFG LSRLIVEERK RPSVEKATTK KRTLRKNDRK 480

KRYTVVGNPY WMAPEMLNGK SYDETVDIFS FGIVLCEIIG QVYADPDCLP RTLDFGLNVK 540

LFWEKFVPTD CPPAFFPLAA ICCRLEPESR PAFSKLEDSF EALSLYLGEL GIPLPAELEE 600

LDHTVSMQYG LTRDSPP 617

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ATTTGTCAGT CCCAGCCTAC TTCACCTCCA GAGACCCATT TCGGTGTTCA 60

GAGTGCCAGG ATTCCCTCAC CAACTGGTAC TACGAGAAGG ATGGGAAGCT CTACTGTCGC 120

AAGGACTACT GGGGGAAGTT TGGGGAGTTC TGTCATGGGT GCTCCCTGCT GATGACAGGG 180

CCTTTTATGG TTGCGGGGGA GTTCAAGTAC CACCCAGAGT GCTTTGCCTG TATGAGCTGC 240

AAGGTGATCA TTGAGGATGG GGATGCATAT GCACTGGTGC AGCATGCCAC CCTCTACTGT 300

GGGAAATGCC ACAATGAGGT GGTGCTGGCA CCCATGTTTG AGAGACTCTC CACAGAGTCT 360

GTTCAGAACC AGCTGCCCTA CTCTGTCACA CTCATCTCCA TGCCGGCCAC CACTGAGGGC 420

AGGCGGGGCT TCTCTGTGTC CGTGGAGAGT GCCTGTTCCA ACTACGCCAC CACCGTGCAA 480

GTGAAAGAGG TCAACCGGAT GCACATCAGT CCCAACAATC GCAATGCCAT CCATCCTGGG 540

GACCGTATTC TGGAGATCAA TGGGATCCCT GTCCGCACAC TTCGAGTGGA GGAGGTGGAG 600

GATGCAGTTA GCCAGACGAG CCAGACACTT CAGCTGCTGA TTGAACATGA CCCTGTCTCC 660

CAGCGCCTGG ATCAGCTGCG GCTGGAGGCC CGGCTCTCTC CTCACATGCA GAATGCTGAA 720

CACCCCCACA CCCTCAGCAC GCTGGACACC AAGGAGAATC TGGAGGGGAC ACTGAGGAGA 780

CGCTCCCTGA GGCGCAGTAA CAGCATCTCC AAGTCCCCTG GCCCCAGCTC CCCAAAGGAG 840

CCCCTGCTAT TCAGCCGTGA CATCAGCCGC TCAGAATCCC TTCGTTGTTC CAGCAGCTAT 900

TCACAGCAGA TCTTCCGGCC CTGTGACCTA ATCCACGGGG AGGTCCTGGG GAAGGGCTTC 960

TTTGGGCAAG CTATAAAGGT GACACACAAA GCCACAGGCA AAGTGATGGT CATGAAGGAG 1020

TTAATTCGAT GTGATGAGGA GACCCAGAAG ACTTTTCTGA CTGAGGTGAA AGTGATGCGC 1080

ATCCTGGACC ACCCCAATGT GCTCAAGTTC ATTGGTGTGC TGTACAAGGA TAAGAAGCTA 1140

AACCTGCTGA CAGAGTACAT TGAGGGGGGC ACACTGAAGG ATTTCCTGCG AGGAATGGAT 1200

CCGTTCCCCT GGCAGCAGAA GGTCAGATTT GCCAAAGGAA TCGCCTCGGG AATGGCCTAT 1260

TTGCACTCTA TGTGCATCAT CCACCGGGAT TTGAACTCAC ACAACTGCCT CATCAAGTTG 1320

GACAAGACCG TGGTGGTGGC AGACTTTGGG CTGTCACGGC TCATAGTGGA AGAGAGGAAA 1380

AGGCCCTCTG TGGAAAAGGC CACCACCAAG AAACGCACCT TGCGCAAGAA TGACCGCAAG 1440

AAGCGCTACA CAGTGGTGGG AAACCCCTAC TGGATGGCTC CTGAGATGCT GAATGGAAAG 1500

AGCTATGATG AGACGGTGGA TATCTTCTCC TTTGGGATCG TTCTCTGCGA GATTATTGGA 1560

CAGGTATATG CAGATCCTGA CTGCCTTCCC CGAACACTGG ACTTTGGCCT CAATGTGAAG 1620

CTTTTCTGGG AGAAGTTTGT TCCCACAGAT TGTCCCCCAG CCTTCTTCCC GCTGGCCGCC 1680

ATCTGCTGCA GACTAGAGCC TGAGAGCAGA CCAGCATTCT CGAAACTGGA GGACTCCTTT 1740

GAGGCCCTCT CCCTGTACCT GGGGGAGCTG GGCATCCCGC TGCCTGCAGA GCTGGAGGAG 1800

TTGGACCACA CTGTGAGCAT GCAGTACGGC CTGACCCGGG ACTCACCCCC CTAG 1854

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRILDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+ ++++pw+q+vr+ak+iasG++ylhs++iihr

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRGMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  429

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerk++      +k+r+l+k+drkkr+tvvG+P

Q: 430   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPsvekatTKKRTLRKNDRKKRYTVVGNP  489

         *******************************9999999999*******************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vd+fsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 490   YWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  549

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 550   DCPPAFFPLAAICCRLEPESRPAFSKLEDS  579

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RILDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRGM DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRPSVEKATT KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDIF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCRLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013