EKS-CAJ-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.2	4.1E-140	205	492	288

Status

Unreviewed

Ensembl Protein

ENSCJAP00000020730

UniProt Accession

F7H653;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000011244	ENSCJAP00000020730	ENSCJAT00000021911
ENSCJAG00000011244	ENSCJAP00000020739	ENSCJAT00000021921

Organism

Callithrix jacchus

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MEAAAAAPRP RLLLLVLAAA AAAAALLLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE 60

TTDKVIHNTM CIAETDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKPSPG 120

LGPVELAAVI AGPVCFVCVS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 180

IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 240

SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300

GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 360

ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 420

HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 480

ARLTALRIKK TLSQLSQQEG IKM 503

Nucleotide Sequence
(FASTA)

ATGGAGGCGG CGGCCGCTGC TCCGCGTCCC CGACTGCTCC TCCTTGTGCT GGCGGCGGCA 60

GCGGCGGCGG CGGCGCTGCT GCTCCCGGGG GCGACGGCAT TACAGTGTTT CTGCCACCTC 120

TGTACAAAAG ACAATTTTAC TTGTGTGACA GATGGGCTCT GCTTTGTCTC TGTCACGGAG 180

ACCACAGACA AAGTTATACA CAACACCATG TGTATAGCTG AAACTGACTT AATTCCTCGA 240

GATAGGCCAT TTGTATGTGC ACCCTCTTCA AAAACTGGGT CTGTGACTAC AACATATTGC 300

TGCAATCAGG ACCATTGCAA TAAAATAGAA CTTCCAACTA CTGTGAAGCC ATCACCTGGC 360

CTTGGTCCCG TGGAACTGGC AGCTGTCATT GCTGGACCGG TGTGCTTCGT CTGCGTCTCA 420

CTCATGTTGA TGGTCTATAT CTGCCACAAC CGCACAGTCA TTCACCATCG AGTGCCTAAT 480

GAAGAGGATC CTTCATTAGA TCGCCCTTTT ATTTCAGAGG GTACTACATT GAAAGACTTA 540

ATTTATGATA TGACAACGTC AGGTTCTGGC TCAGGTTTAC CATTGCTTGT TCAGAGAACA 600

ATTGCGAGAA CTATTGTGTT ACAAGAAAGC ATTGGCAAAG GTCGATTTGG AGAAGTTTGG 660

AGAGGAAAGT GGAGGGGAGA AGAAGTTGCT GTTAAGATAT TCTCCTCTAG AGAAGAACGT 720

TCATGGTTCC GTGAGGCAGA GATTTATCAA ACTGTAATGT TACGTCATGA AAATATCCTG 780

GGATTTATAG CAGCAGACAA TAAAGACAAT GGTACTTGGA CTCAGCTCTG GTTGGTGTCA 840

GATTATCATG AGCATGGATC CCTTTTTGAT TACTTAAACA GATACACAGT TACTGTGGAA 900

GGAATGATAA AACTTGCTCT GTCCACAGCA AGTGGTCTTG CCCATCTTCA CATGGAGATT 960

GTTGGTACCC AAGGAAAGCC AGCCATTGCT CATAGGGACT TGAAATCGAA GAATATCTTG 1020

GTAAAGAAGA ATGGAACTTG CTGTATTGCA GACTTAGGAC TGGCAGTAAG ACATGATTCA 1080

GCCACAGATA CAATTGATAT TGCTCCAAAC CACAGAGTGG GAACAAAAAG GTACATGGCC 1140

CCTGAAGTTC TCGATGATTC CATAAATATG AAACATTTTG AATCCTTCAA ACGTGCCGAC 1200

ATCTATGCAA TGGGCTTAGT ATTCTGGGAA ATTGCTCGAC GATGTTCCAT TGGTGGTATT 1260

CATGAAGATT ACCAGCTGCC TTATTATGAT CTTGTACCTT CTGACCCATC AGTTGAAGAA 1320

ATGAGAAAAG TCGTTTGTGA ACAGAAGTTA AGGCCAAATA TCCCAAACAG ATGGCAGAGC 1380

TGTGAAGCCC TGAGAGTAAT GGCTAAAATT ATGAGAGAAT GTTGGTATGC CAATGGAGCA 1440

GCTAGGCTTA CCGCATTGCG GATTAAGAAA ACATTATCAC AACTCAGTCA GCAGGAAGGC 1500

ATCAAAATGT AA 1512

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 205   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  264

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 265   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 383   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  441

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013