EKS-CAJ-00499

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00499

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	397.9	4.3E-119	22	284	263

Status

Unreviewed

Ensembl Protein

ENSCJAP00000020755

UniProt Accession

F7GQS9;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK4

Gene Synonyms/Alias

RIPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000011251	ENSCJAP00000020755	ENSCJAT00000021938
ENSCJAG00000011251	ENSCJAP00000020764	ENSCJAT00000021947

Organism

Callithrix jacchus

Functional Description

Protein Length

782

Protein Sequence
(FASTA)

MEGDSGTPWA LGLLRTFDAG EFTGWEKVGS GGFGQVYKVR HVHWKTWLAI KCSPSLHVDN 60

RWERLELLEE AKKMEMAKFR YILPVYGICH EPVGLVMEYM ETGSLEKLLA AEPLPWDLRF 120

RVIHETAVGM NFLHCMSPPL LHLDLKPANI LLDAHYHVKI SDFGLAKCNG LSHSHDLSMD 180

GLFGTIAYLP PERIREKSRL FDTKHDVYSF AIVIWSVLTQ KKPFADEKNI LHIMVKVVKG 240

HRPELPPVCR ARPRACSHLI RLMQRCWQGD PRVRPTFQEI TSETEDLCEK PDGEVKETAH 300

DDVKSPLEPR SEVVPVSSRL KRASAPTFDN DHSLSELLSQ LDSGVSQAVE GPEELSRSSS 360

ESKLPSTGSG KRLSGVSSVD SAFSSRGSLS LSFEREPSTS DLGTTDIQKK KLVDAIVSGD 420

TSKLMKILQP QDVDLVLDGG ASLLHLAVEA GQEECVKWLL LNNANPNLTN RRGSTPLHTA 480

VERRGRGVVE LLLARKISVN AKDEDQWTAL HFAAQSGDES SMRLLLEKNA SVNEVDFEGR 540

TPMHVACQHG QENIVRILLR RGVDVSLPGK DAWLPLHYAA WQGHLPIVKL LAKQPGVSVN 600

AQTLDGRTPL HLAAQRGHYR VARILIDLCS DVNVCSLLAQ TPLHVAAETG HTSTARLLLH 660

RGAGKEAVTS DGYTALHLAA RNGHLATVKL LVEEKANVLA RGPLNQTALH LAAAHGHSEV 720

VEELVSADVI DLFDEQGLSA LHLAAQGRHA QTVETLLRHG AYINLQSLKF QGGHGPAATL 780

LR 782

Nucleotide Sequence
(FASTA)

ATGGAGGGCG ACAGCGGGAC CCCGTGGGCC CTGGGGCTGC TGCGCACCTT CGACGCGGGC 60

GAGTTTACCG GCTGGGAGAA GGTGGGCTCG GGCGGCTTCG GGCAGGTGTA CAAGGTGCGC 120

CACGTCCACT GGAAGACCTG GCTCGCCATC AAGTGCTCGC CCAGCCTGCA CGTCGACAAC 180

AGGTGGGAGC GCCTGGAGCT TTTGGAAGAA GCCAAGAAGA TGGAGATGGC CAAGTTTCGT 240

TACATCCTCC CTGTGTACGG TATCTGCCAT GAACCCGTCG GCCTGGTCAT GGAGTACATG 300

GAGACGGGCT CCCTGGAGAA GCTGCTGGCC GCAGAGCCGC TGCCATGGGA TCTGCGGTTC 360

CGCGTCATCC ACGAGACTGC GGTGGGCATG AACTTCCTGC ACTGCATGTC CCCGCCGCTC 420

CTGCACCTGG ACCTCAAGCC CGCCAACATC CTGCTGGATG CCCACTACCA CGTCAAGATC 480

TCTGATTTTG GGCTGGCCAA GTGCAACGGG TTGTCCCACT CACACGACCT CAGCATGGAC 540

GGCCTGTTCG GCACCATCGC CTACCTCCCT CCAGAGCGCA TCAGGGAGAA GAGCCGGCTC 600

TTCGACACCA AGCATGACGT ATACAGCTTC GCCATCGTCA TCTGGAGCGT GCTCACGCAG 660

AAGAAGCCGT TTGCAGATGA GAAGAACATC CTGCACATCA TGGTGAAGGT GGTGAAGGGC 720

CACCGCCCCG AGCTGCCGCC TGTGTGCAGA GCCCGGCCGC GCGCCTGCAG CCACCTGATA 780

CGCCTCATGC AGCGGTGCTG GCAGGGGGAC CCGCGAGTCC GGCCCACCTT CCAAGAAATT 840

ACTTCTGAAA CCGAGGACCT GTGTGAAAAG CCTGATGGTG AAGTGAAAGA AACTGCTCAT 900

GACGACGTGA AAAGCCCCCT GGAGCCCAGG AGTGAGGTGG TACCTGTGTC TTCGAGGCTC 960

AAGCGGGCCT CCGCCCCCAC CTTCGATAAT GACCACAGCC TCTCTGAGCT GCTCTCGCAG 1020

CTGGACTCCG GAGTTTCCCA GGCCGTCGAG GGCCCGGAGG AGCTCAGCCG CAGCTCCTCT 1080

GAGTCCAAGC TGCCATCGAC CGGCAGTGGC AAGAGGCTCT CGGGGGTGTC CTCGGTGGAC 1140

TCTGCCTTCT CTTCCAGAGG ATCACTGTCG CTGTCCTTTG AGCGGGAGCC TTCGACTAGC 1200

GATCTGGGCA CCACAGACAT CCAGAAGAAG AAGCTCGTGG ATGCCATCGT GTCCGGGGAC 1260

ACCAGCAAGC TGATGAAGAT CCTGCAGCCA CAGGACGTGG ACCTGGTGCT GGACGGCGGC 1320

GCCAGCCTGC TGCACCTGGC GGTGGAGGCC GGGCAGGAGG AGTGCGTCAA GTGGCTGCTG 1380

CTCAACAATG CCAACCCCAA CCTGACCAAC CGCAGGGGCT CCACCCCGCT GCACACGGCC 1440

GTGGAGAGGC GGGGGCGGGG CGTTGTGGAG CTCCTGCTGG CACGGAAGAT CAGCGTCAAC 1500

GCCAAGGACG AGGACCAGTG GACGGCCCTC CACTTTGCTG CCCAGAGCGG GGACGAGTCT 1560

AGCATGCGGC TGCTGCTGGA GAAGAACGCC TCGGTCAACG AGGTGGACTT CGAGGGCCGG 1620

ACGCCCATGC ACGTGGCCTG CCAGCATGGG CAGGAGAACA TCGTGCGCAT CCTGCTGCGC 1680

CGAGGCGTGG ACGTGAGCCT GCCGGGCAAG GACGCCTGGC TGCCTCTGCA CTACGCGGCC 1740

TGGCAGGGCC ACCTGCCTAT CGTCAAGCTG CTGGCCAAGC AGCCGGGGGT GAGCGTGAAC 1800

GCGCAGACGC TGGACGGGAG GACGCCCCTG CACCTGGCCG CACAGCGCGG GCACTACCGC 1860

GTGGCCCGCA TCCTCATCGA CCTGTGCTCT GACGTCAATG TCTGCAGCCT GCTGGCACAG 1920

ACGCCCCTGC ACGTGGCCGC CGAGACGGGG CACACCAGCA CCGCCAGGCT GCTCCTGCAT 1980

CGGGGCGCCG GCAAGGAGGC TGTGACCTCG GACGGCTACA CTGCCCTGCA CCTGGCTGCC 2040

CGCAACGGAC ACCTGGCCAC CGTCAAGCTC CTCGTTGAGG AGAAGGCCAA TGTGCTGGCC 2100

CGGGGACCCC TGAACCAGAC GGCGCTGCAC CTGGCTGCCG CCCATGGGCA CTCAGAGGTG 2160

GTGGAGGAGT TGGTCAGCGC CGACGTCATC GACCTGTTCG ACGAGCAGGG GCTCAGTGCA 2220

CTGCACCTGG CCGCCCAGGG CCGGCACGCA CAGACGGTGG AGACCCTGCT CAGGCACGGG 2280

GCCTACATCA ACCTGCAGAG CCTCAAGTTC CAGGGTGGCC ACGGCCCCGC TGCCACGCTC 2340

CTGCGGTGA 2349

Domain Profile

S: 1     leelelvgsGgfgkvfkarhrkwrvevavk.slvlktdaldserkelleeakkmeklrfs  59

         ++ +e+vgsGgfg+v+k+rh++w++++a+k s++l++d+   er elleeakkme+++f+

Q: 22    FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKcSPSLHVDN-RWERLELLEEAKKMEMAKFR  80

         5789**********************************6.568899**************

S: 60    yvlkllGvikeeeklglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhslk  119

         y+l+++G+++e+  +glvmeyme+GsLeklL++e +lpw+l+fR+++e+++gmn+Lh+++

Q: 81    YILPVYGICHEP--VGLVMEYMETGSLEKLLAAE-PLPWDLRFRVIHETAVGMNFLHCMS  137

         ************..********************.*************************

S: 120   PpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPellee  179

         Ppllh+DLkp+niLlD+++hvki+DfGl+k+ ++ s+s+++s+++++Gt+aYl+Pe+++e

Q: 138   PPLLHLDLKPANILLDAHYHVKISDFGLAKC-NGLSHSHDLSMDGLFGTIAYLPPERIRE  196

         *******************************.****************************

S: 180   vnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelPrev  239

         +++ +++k+DvYsfaiviW vl++k+p+++ekn+l+i+++v kg+RPel +v++++Pr++

Q: 197   KSRLFDTKHDVYSFAIVIWSVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRAC  256

         ************************************************************

S: 240   pqlieLmkrcWeadpeeRPsFleieekt  267

         ++li+Lm+rcW+ dp+ RP+F+ei+++t

Q: 257   SHLIRLMQRCWQGDPRVRPTFQEITSET  284

         ************************9986

Domain Sequence
(FASTA)

FTGWEKVGSG GFGQVYKVRH VHWKTWLAIK CSPSLHVDNR WERLELLEEA KKMEMAKFRY 60

ILPVYGICHE PVGLVMEYME TGSLEKLLAA EPLPWDLRFR VIHETAVGMN FLHCMSPPLL 120

HLDLKPANIL LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG LFGTIAYLPP ERIREKSRLF 180

DTKHDVYSFA IVIWSVLTQK KPFADEKNIL HIMVKVVKGH RPELPPVCRA RPRACSHLIR 240

LMQRCWQGDP RVRPTFQEIT SET 263

Keyword

ANK repeat; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12796	; Ank_2; 3.
PF00069	; Pkinase; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 9.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013