EKS-CAJ-00303

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00303

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	501.5	9.7E-151	643	900	258

Status

Unreviewed

Ensembl Protein

ENSCJAP00000020916

UniProt Accession

F7H0K6;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100402965

Gene Synonyms/Alias

LOC100402965;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000011307	ENSCJAP00000042588	ENSCJAT00000057781
ENSCJAG00000011307	ENSCJAP00000020951	ENSCJAT00000022153
ENSCJAG00000011307	ENSCJAP00000020916	ENSCJAT00000022112

Organism

Callithrix jacchus

Functional Description

Protein Length

1217

Protein Sequence
(FASTA)

SFQSVREVTG YVLVALNQFR YLPLENLRII RGTKLYEDRY ALAIFLNYRK DGNFGLQELG 60

LKNLTEILNG GVYVDQNKFL CYADTIHWQD IVRNPWPSNL TLVSTNGSSG CGRCHKSCTG 120

RCWGPTENHC QTLTRTVCAE QCDGRCYGPY VSDCCHRECA GGCSGPKDTD CFACMNFNDS 180

GACVTQCPQT FVYNPTTFQL EHNFNAKYTY GAFCVKKCPH NFVVDSSSCV RACPSSKMEV 240

EENGIKMCKP CTDICPKACD GIGTGSLMSA QTVDSSNIDK FINCTKINGN LIFLVTGIHG 300

DPYNAIEAID PEKLNVFRTV REITGFLNIQ SWPPNMTDFS VFSNLVTIGG RVLYSGLSLL 360

ILKQQGITSL QFQSLKEISA GNIYITDNSN LCYYHTINWT TLFSTINQRI VIRDNRKAEN 420

CTAEGMVCNH LCSSDGCWGP GPDQCLSCRR FSRGRICIES CNLYDGEFRE FENGSICVEC 480

DPQCEKMEDG LLTCHGPGPD NCTKCSHFKD GPNCVEKCPD GLQGANSFIF KYADPDRECH 540

PCHPNCTQGC NGPTSHDCIY YPWTGHSTLP QHARTPLIAA GVIGGLFILV IVGLTFAVYV 600

RRKSIKKKRA LRRFLETELV EPLTPSGTAP NQAQLRILKE TELKRVKVLG SGAFGTVYKG 660

IWVPEGETVK IPVAIKILNE TTGPKANVEF MDEALIMASM DHPHLVRLLG VCLSPTIQLV 720

TQLMPHGCLL EYVHEHKDNI GSQLLLNWCV QIAKGMMYLE ERRLVHRDLA ARNVLVKSPN 780

HVKITDFGLA RLLEGDEKEY NADGGKMPIK WMALECIHYR KFTHQSDVWS YGVTIWELMT 840

FGGKPYDGIP TREIPDLLEK GERLPQPPIC TIDVYMVMVK CWMIDADSRP KFKELAAEFS 900

RMARDPQRYL VIQGDDRMKL PSPNDSKFFQ NLLDEEDLED MMDAEEYLVP QAFNIPPPIY 960

TSRARIDSNR NQFVYRDGGF AAEQGVSVPY RAPTSTIPEA PVAQGATAEI FDDSCCNGTL 1020

RKPVAPHVQE DSSTQRYSAD PTVFAPERSP RGELDEEGYM TPMRDKAKQE YLNPVEENPF 1080

VSRRKNGDLQ ALDNPEYHNA SNGPSKAEDE YVNEPLYLNT FANALGKAEY LKNNVLSVPE 1140

KAKKAFDNPD YWNHSLPPRS TLQHPDYLQE YSTKYFYKQN GRIRPIVAEN PEYLSEFSLK 1200

PGTVLPPPPY RHRNTVV 1217

Nucleotide Sequence
(FASTA)

TCTTTTCAGT CTGTTCGAGA AGTCACAGGC TACGTGTTAG TGGCTCTTAA TCAGTTTCGT 60

TACCTGCCTC TGGAGAATTT ACGCATTATT CGTGGGACAA AACTTTATGA GGACCGATAT 120

GCCTTGGCAA TATTTTTAAA CTACAGAAAA GATGGAAACT TTGGACTTCA AGAACTTGGA 180

TTAAAGAACT TGACAGAAAT CCTAAATGGT GGAGTCTATG TAGACCAGAA CAAATTCCTT 240

TGTTATGCAG ACACCATTCA TTGGCAAGAT ATTGTTCGGA ATCCATGGCC TTCCAACTTG 300

ACTCTTGTGT CAACAAATGG TAGTTCAGGA TGTGGACGTT GCCATAAGTC CTGTACTGGC 360

CGTTGCTGGG GACCCACAGA AAATCATTGC CAGACTTTGA CAAGGACGGT GTGTGCAGAA 420

CAATGTGACG GCAGATGCTA CGGACCCTAC GTCAGTGACT GCTGCCATCG AGAATGTGCT 480

GGAGGATGCT CAGGACCTAA GGACACAGAC TGTTTCGCCT GCATGAATTT CAATGACAGT 540

GGAGCATGTG TTACTCAGTG TCCCCAGACC TTTGTCTACA ATCCAACCAC CTTTCAACTG 600

GAGCACAATT TCAATGCAAA GTACACATAT GGAGCATTCT GTGTCAAGAA ATGTCCACAT 660

AACTTTGTGG TGGATTCCAG TTCTTGTGTG CGTGCCTGCC CTAGTTCCAA GATGGAAGTA 720

GAAGAAAATG GGATTAAAAT GTGTAAACCT TGCACTGATA TTTGCCCAAA AGCTTGTGAT 780

GGCATTGGCA CGGGATCACT GATGTCAGCT CAGACTGTGG ATTCCAGTAA CATTGACAAA 840

TTCATAAACT GTACCAAGAT CAATGGGAAT TTGATCTTTT TAGTCACTGG TATTCATGGG 900

GACCCTTACA ATGCAATTGA AGCCATAGAC CCAGAGAAAC TAAATGTCTT TCGGACAGTC 960

AGAGAGATAA CAGGTTTCTT GAACATACAG TCATGGCCCC CAAACATGAC TGATTTCAGT 1020

GTTTTTTCTA ACCTGGTGAC CATTGGTGGA AGAGTACTCT ATAGTGGCCT CTCCTTGCTT 1080

ATCCTCAAGC AACAGGGCAT CACGTCTCTG CAGTTCCAGT CCCTGAAGGA AATTAGCGCA 1140

GGAAACATCT ATATTACAGA CAACAGCAAT CTATGTTATT ATCATACCAT TAACTGGACA 1200

ACACTCTTCA GCACAATCAA CCAAAGGATA GTAATCCGGG ACAATAGAAA AGCTGAAAAC 1260

TGTACTGCCG AAGGAATGGT GTGCAACCAT CTGTGTTCAA GTGATGGCTG TTGGGGACCT 1320

GGGCCAGACC AATGCCTGTC GTGTCGTCGC TTCAGTAGAG GAAGGATATG CATAGAGTCT 1380

TGTAACCTCT ATGACGGTGA ATTTCGGGAG TTTGAGAATG GCTCCATCTG TGTGGAGTGT 1440

GACCCCCAGT GTGAGAAGAT GGAAGATGGC CTCCTCACAT GCCATGGACC GGGTCCTGAC 1500

AACTGTACAA AGTGCTCTCA TTTTAAAGAT GGCCCAAACT GTGTGGAAAA ATGTCCAGAT 1560

GGCTTACAGG GGGCAAACAG TTTCATTTTC AAGTATGCTG ATCCGGATCG GGAGTGCCAC 1620

CCATGCCATC CAAACTGTAC GCAAGGGTGT AACGGTCCCA CTAGTCATGA CTGCATTTAC 1680

TACCCATGGA CGGGCCATTC CACTTTACCA CAACATGCTA GAACTCCCCT GATTGCAGCT 1740

GGAGTAATTG GTGGGCTCTT CATTCTGGTC ATTGTGGGTC TGACATTTGC TGTTTATGTT 1800

AGAAGGAAGA GCATCAAAAA GAAAAGAGCC TTGAGAAGAT TCTTGGAAAC AGAGTTGGTA 1860

GAACCTTTAA CTCCCAGTGG CACAGCACCG AATCAAGCAC AACTTCGTAT TTTGAAAGAA 1920

ACTGAGCTGA AGAGGGTAAA AGTCCTTGGC TCAGGTGCTT TTGGAACAGT GTATAAAGGT 1980

ATTTGGGTAC CGGAAGGAGA AACTGTGAAG ATTCCTGTGG CTATTAAGAT TCTTAATGAG 2040

ACAACTGGTC CCAAGGCAAA TGTGGAGTTC ATGGATGAAG CTCTGATCAT GGCAAGTATG 2100

GATCATCCAC ACCTAGTTCG GTTGCTGGGT GTGTGTCTAA GCCCAACCAT CCAGCTGGTT 2160

ACTCAGCTTA TGCCCCATGG CTGCCTGTTG GAGTATGTCC ATGAGCACAA GGATAACATT 2220

GGATCACAAC TGCTGCTTAA CTGGTGTGTC CAGATAGCTA AGGGAATGAT GTACCTGGAA 2280

GAAAGACGGC TTGTTCATCG GGATTTGGCA GCCCGCAATG TCTTAGTGAA ATCTCCAAAC 2340

CATGTGAAAA TCACAGATTT TGGACTAGCC AGACTGTTAG AAGGAGATGA AAAAGAGTAT 2400

AATGCTGATG GAGGAAAGAT GCCAATTAAA TGGATGGCTC TGGAGTGTAT ACATTACAGG 2460

AAATTCACCC ATCAGAGTGA CGTTTGGAGC TATGGAGTTA CCATATGGGA ACTGATGACC 2520

TTTGGAGGAA AACCCTATGA TGGAATTCCA ACTCGAGAAA TCCCTGATTT ATTAGAGAAA 2580

GGAGAACGTT TGCCTCAACC TCCCATCTGC ACTATTGACG TTTACATGGT CATGGTCAAA 2640

TGTTGGATGA TTGATGCTGA CAGTAGACCC AAATTTAAGG AACTGGCTGC TGAGTTTTCA 2700

AGGATGGCTC GAGACCCTCA AAGATACCTA GTTATTCAGG GTGATGATCG AATGAAGCTT 2760

CCCAGTCCAA ATGACAGCAA GTTCTTTCAG AATCTCTTGG ATGAAGAAGA TTTGGAAGAT 2820

ATGATGGATG CTGAGGAGTA CTTGGTCCCT CAGGCTTTCA ACATCCCACC TCCCATTTAT 2880

ACTTCCAGAG CAAGAATTGA CTCAAATAGG AACCAGTTTG TATACCGAGA TGGAGGTTTT 2940

GCTGCAGAAC AAGGAGTGTC TGTGCCCTAC AGAGCCCCAA CTAGCACAAT TCCAGAAGCT 3000

CCTGTTGCAC AGGGTGCTAC AGCTGAGATT TTTGATGACT CCTGCTGTAA TGGCACCCTA 3060

CGCAAGCCAG TGGCACCCCA TGTCCAAGAG GACAGTAGCA CTCAGAGGTA CAGTGCTGAC 3120

CCCACCGTGT TTGCCCCAGA ACGGAGCCCA CGAGGAGAGC TGGATGAGGA AGGTTACATG 3180

ACTCCTATGC GAGACAAAGC CAAACAAGAA TACCTGAATC CAGTGGAGGA GAACCCTTTT 3240

GTTTCTCGAA GAAAAAATGG AGACCTTCAA GCATTGGATA ATCCCGAATA TCACAACGCA 3300

TCCAATGGTC CATCCAAGGC CGAGGATGAG TATGTGAATG AGCCGCTGTA CCTCAACACC 3360

TTTGCCAATG CCTTGGGAAA AGCTGAGTAC CTAAAGAACA ATGTACTGTC AGTGCCAGAG 3420

AAGGCCAAGA AAGCGTTTGA CAACCCTGAC TACTGGAACC ACAGCTTGCC ACCTCGGAGC 3480

ACCCTCCAGC ACCCAGACTA CCTGCAGGAG TACAGCACAA AATATTTTTA TAAACAGAAT 3540

GGGCGGATCC GGCCTATTGT GGCAGAGAAT CCTGAATACC TCTCTGAGTT CTCCCTGAAG 3600

CCAGGCACTG TGCTGCCACC TCCACCTTAC AGACACCGGA ATACTGTGGT GTAA 3654

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 643   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  702

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 703   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  762

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 763   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  822

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 823   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  882

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 883   MIDADSRPKFKELAAEFS  900

         ****************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013