EKS-CAJ-00052

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00052

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	405.0	3.4E-121	313	570	258

Status

Unreviewed

Ensembl Protein

ENSCJAP00000022880

UniProt Accession

F7IPQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

ARAF

Gene Synonyms/Alias

ARAF;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000012431	ENSCJAP00000022829	ENSCJAT00000024152
ENSCJAG00000012431	ENSCJAP00000022880	ENSCJAT00000024207

Organism

Callithrix jacchus

Functional Description

Protein Length

609

Protein Sequence
(FASTA)

MEPPRGPPAN GAEPCRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 60

VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 120

HGFRCQTCGY KFHQHCSSKV PTVCVDMSTT CQQPSRFYHS VQDLSRGSKQ HEAPSNRPLN 180

ESLTPQGPSP CNQHCDPEHF PFPTPANAPL QRIRSTSTPN VHMVSSTAPM DSNLIQLTGQ 240

SFSTDAASSR GGGDGAPRGS PSPVSVSSGR KSPHSKSPAE QRERKSLADD KKKVKNLGYR 300

DSGYYWEVPP SEVQLLKRIG TGSFGTVFRG RWHGDVAVKV LKVSQPTAEQ AQAFKNEMQV 360

LRKTRHVNIL LFMGFMTRPG FAIITQWCEG SSLYHHLHVA DTRFDMVQLI DVARQTAQGM 420

DYLHAKNIIH RDLKSNNIFL HEGLTVKIGD FGLATVKTRW SGAQPLEQPS GSVLWMAAEV 480

IRMQDPNPYS FQSDVYAYGV VLYELMTGSL PYSHIGCRDQ IIFMVGRGYL SPDLSKISSN 540

CPKAMRRLLS DCLKFQREER PLFPQILATI ELLQRSLPKI ERSASEPSLH RTQADELPAC 600

LLSAARLVP 609

Nucleotide Sequence
(FASTA)

ATGGAGCCAC CACGGGGCCC CCCTGCCAAT GGGGCCGAGC CGTGCCGGGC AGTGGGCACC 60

GTCAAAGTGT ACCTGCCCAA CAAGCAACGC ACAGTGGTAA CTGTCCGGGA TGGCATGAGT 120

GTCTACGACT CTCTAGACAA GGCCCTGAAG GTGCGGGGTC TAAATCAGGA CTGCTGTGTG 180

GTCTACCGAC TCATCAAGGG ACGAAAGACG GTTACTGCCT GGGACACAGC CATCGCTCCC 240

CTGGATGGCG AGGAGCTCAT TGTCGAGGTC CTTGAAGATG TTCCGCTGAC CATGCACAAT 300

TTTGTACGGA AGACCTTCTT CAGCCTGGCG TTCTGCGACT TCTGCCTTAA GTTTCTGTTC 360

CATGGCTTCC GTTGCCAAAC CTGTGGCTAC AAGTTCCACC AGCATTGTTC CTCCAAGGTC 420

CCCACAGTCT GTGTTGACAT GAGTACCACC TGCCAACAGC CCTCAAGGTT CTACCACAGT 480

GTCCAGGATT TGTCCAGAGG CTCCAAACAG CATGAGGCTC CCTCAAACCG CCCCCTGAAT 540

GAGTCGCTAA CCCCCCAGGG TCCCAGCCCC TGCAACCAGC ACTGTGACCC GGAGCACTTC 600

CCCTTCCCCA CCCCAGCCAA TGCTCCCCTG CAGCGCATCC GCTCCACGTC CACTCCCAAC 660

GTCCATATGG TCAGCTCCAC GGCTCCCATG GACTCCAACC TCATCCAGCT CACTGGCCAG 720

AGTTTCAGCA CTGATGCTGC CAGTAGTAGA GGAGGTGGAG ATGGAGCCCC CCGGGGGAGC 780

CCCAGCCCAG TCAGCGTGTC CTCGGGGAGG AAGTCCCCAC ATTCCAAGTC ACCAGCAGAG 840

CAGCGTGAGC GGAAGTCCTT GGCTGATGAC AAGAAAAAAG TGAAGAACCT GGGGTACCGG 900

GACTCAGGCT ATTACTGGGA GGTACCACCC AGTGAGGTGC AGCTGCTGAA GAGGATTGGG 960

ACAGGCTCGT TTGGCACCGT GTTTCGAGGG CGGTGGCATG GCGATGTGGC TGTGAAGGTG 1020

CTCAAGGTGT CCCAGCCCAC AGCTGAGCAG GCCCAAGCCT TCAAGAACGA GATGCAGGTG 1080

CTCAGGAAGA CGCGACATGT CAACATCTTG CTGTTTATGG GCTTCATGAC CCGGCCGGGA 1140

TTTGCCATCA TCACACAGTG GTGTGAGGGC TCCAGCCTCT ACCACCACCT GCATGTGGCC 1200

GACACACGCT TCGACATGGT CCAGCTCATC GATGTGGCCC GGCAGACTGC CCAGGGCATG 1260

GACTACCTCC ATGCCAAGAA CATCATCCAC CGAGATCTCA AGTCTAACAA CATCTTCCTA 1320

CACGAGGGGC TCACAGTGAA GATTGGTGAC TTTGGCTTGG CCACGGTGAA GACTCGATGG 1380

AGCGGGGCCC AGCCCTTGGA GCAGCCCTCA GGCTCTGTGC TGTGGATGGC AGCTGAGGTG 1440

ATCCGTATGC AGGACCCGAA CCCCTACAGC TTCCAGTCAG ATGTCTATGC CTATGGGGTT 1500

GTGCTCTACG AGCTCATGAC TGGCTCACTG CCTTACAGCC ACATTGGCTG CCGTGACCAG 1560

ATTATCTTTA TGGTGGGCCG TGGCTATCTG TCCCCGGACC TCAGCAAAAT CTCCAGCAAC 1620

TGCCCCAAGG CCATGCGGCG CCTGCTGTCT GACTGCCTCA AGTTCCAGCG GGAGGAGCGG 1680

CCCCTCTTCC CCCAGATTTT GGCCACAATT GAGCTGCTGC AACGGTCACT CCCCAAGATT 1740

GAGCGGAGTG CCTCGGAACC CTCCTTGCAC CGCACCCAGG CTGATGAGTT GCCTGCCTGC 1800

CTACTCAGCG CAGCCCGCCT TGTGCCTTAG 1830

Domain Profile

S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60

         v+l ++iG+G+fGtv+rg+whGdvavk+l+v+++++eq++aFk+e+++++ktRh+ni+LF

Q: 313   VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLF  372

         67899*******************************************************

S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         mG++++p +ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmdYLhak+i+h+D

Q: 373   MGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRD  432

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180

         lks+ni+l+egl+v+i+DFgl++vk+++sg  ++ le+p+g++l++a+evir+      q

Q: 433   LKSNNIFLHEGLTVKIGDFGLATVKTRWSG--AQPLEQPSGSVLWMAAEVIRM------Q  484

         ******************************..9********************......*

S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238

         d +p+s++sDvya+G+vlyel++++lpy++  ++dqi+f+vgrG l+pdlsk++s++pk+

Q: 485   DPNPYSFQSDVYAYGVVLYELMTGSLPYSHiGCRDQIIFMVGRGyLSPDLSKISSNCPKA  544

         ************************************************************

S: 239   lkellleClkfekeeRPlftqilkkl  264

         +++ll++Clkf++eeRPlf+qil+++

Q: 545   MRRLLSDCLKFQREERPLFPQILATI  570

         **********************9875

Domain Sequence
(FASTA)

VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VSQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60

MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDY LHAKNIIHRD 120

LKSNNIFLHE GLTVKIGDFG LATVKTRWSG AQPLEQPSGS VLWMAAEVIR MQDPNPYSFQ 180

SDVYAYGVVL YELMTGSLPY SHIGCRDQII FMVGRGYLSP DLSKISSNCP KAMRRLLSDC 240

LKFQREERPL FPQILATI 258

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005057	; F:receptor signaling protein activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR003116	; Raf-like_ras-bd.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF07714	; Pkinase_Tyr; 1.
PF02196	; RBD; 1.

SMARTs

SM00109	; C1; 1.
SM00455	; RBD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50898	; RBD; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013