EKS-CAJ-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	413.9	6.4E-124	26	321	296

Status

Unreviewed

Ensembl Protein

ENSCJAP00000025008

UniProt Accession

F7AK86;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK8

Gene Synonyms/Alias

MAPK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000013551	ENSCJAP00000024996	ENSCJAT00000026423
ENSCJAG00000013551	ENSCJAP00000025013	ENSCJAT00000026441
ENSCJAG00000013551	ENSCJAP00000025008	ENSCJAT00000026436

Organism

Callithrix jacchus

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300

MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360

MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDMS SMSTDPTLAS DTDSSLEASA 420

GPLGCCR 427

Nucleotide Sequence
(FASTA)

ATGAGCAGAA GCAAGCGTGA CAACAATTTT TATAGTGTAG AGATTGGAGA TTCTACATTT 60

ACAGTCCTGA AACGATATCA GAATTTAAAA CCTATAGGCT CAGGAGCTCA AGGAATAGTA 120

TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TCAAGAAGCT AAGCCGACCA 180

TTTCAGAATC AAACTCATGC CAAGCGGGCC TACAGAGAGC TAGTTCTTAT GAAATGTGTT 240

AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTCACAC CACAGAAATC CCTAGAAGAA 300

TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCAA ATCTTTGCCA AGTAATTCAG 360

ATGGAGCTAG ATCATGAAAG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420

CACCTTCACT CCGCTGGAAT TATTCATCGG GACTTAAAGC CTAGTAATAT AGTAGTAAAA 480

TCTGACTGCA CTTTGAAGAT TCTTGACTTT GGTCTGGCCA GGACTGCAGG AACAAGTTTT 540

ATGATGACGC CTTACGTAGT GACTCGCTAC TACAGAGCAC CTGAGGTCAT CCTTGGCATG 600

GGCTACAAGG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660

GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAAT GGAATAAAGT TATTGAGCAG 720

CTTGGAACAC CATGTCCTGA ATTCATGAAG AAACTGCAAC CAACAGTCAG GACTTACGTT 780

GAAAACAGAC CTAAATATGC TGGATATAGC TTCGAGAAAC TCTTCCCCGA TGTACTTTTC 840

CCAGCTGACT CAGAACACAA CAAACTTAAA GCCAGTCAGG CAAGGGATTT GTTATCCAAA 900

ATGCTGGTAA TAGATGCATC TAAAAGGATC TCTGTAGATG AGGCTCTCCA GCACCCGTAC 960

ATCAATGTCT GGTATGATCC TTCTGAAGCA GAAGCTCCAC CACCAAAGAT ACCTGACAAG 1020

CAATTAGATG AAAGGGAACA CACAATAGAA GAGTGGAAAG AATTGATATA TAAGGAAGTT 1080

ATGGACTTGG AGGAGAGAAC CAAGAATGGA GTTATACGGG GGCAGCCCTC TCCTTTAGGT 1140

GCAGCAGTGA TCAATGGCTC TCAGCATCCA TCGTCATCAT CGTCTGTCAA TGATATGTCT 1200

TCAATGTCAA CAGATCCGAC TTTGGCCTCG GATACAGACA GCAGTCTAGA AGCATCAGCG 1260

GGGCCTCTGG GCTGCTGTAG ATGA 1284

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013