EKS-CAJ-00343

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00343

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	244.7	2.3E-72	5	194	190

Status

Unreviewed

Ensembl Protein

ENSCJAP00000025287

UniProt Accession

F6VI25;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K1

Gene Synonyms/Alias

MAP4K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000013713	ENSCJAP00000025287	ENSCJAT00000026721

Organism

Callithrix jacchus

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

FSNHFRLQKL WICMEFCGAG SLQDIYQVTG SLSELQISYV CREVLQGLAY LHSQKKIHRD 60

IKGANILIND AGEVRLADFG ISAQIGATLA RRLSFIGTPY WRAPEVAAVP KGGYNELCDF 120

WSLGITAIEL AELQPPLFDV HPLRVLFLMT KSGYQPPRLK EKGKWSAAFH NFVKVTLTKS 180

PKKRPGATKM LSHQLVSQPG LNRGLILDLL DKLKNPGKGP SIGDIEDEEP ELPPAVPRRI 240

RSTHRSSSLG IPDADCCRSP TAHQRPQEQQ PQVRDPREGA PAPTFLLVIN PLILSSSQNQ 300

SPLSLLTSNP SPRPPAQNHT VFPESLLPRP PAIEPIFVFQ PHSCRGHTSS TAPQDAGILG 360

SPGQGVGETR IMATLASGSG IPQHQDEGPG GIGDDGQLSP GVLVRCASGP PINDLLPGSP 420

RPAQGCALLV KLFNGCPLRI HSTAAWTHPS TKDQHLLLGA EEGIFILNRN LPDHPLPPGG 480

QRKGSFIPEI GNDRKSPLEN GRKTPHLYSH SILGLLERKE TKAGNPIAHI SPHRLLARKN 540

MVSTKIQDTK GCRACCVAEG SSSGGPFLCG ALETSVVLLQ WYQPMNKFLL VRQVLFPLPT 600

PLSVFALLTG PGSELPSVCI GVSPGRSGKS VLFHTVRFGA LSCWLGEMST KTEHKGPVQV 660

TQVEEDMVMV LMDGSLKLVT PEGIPVRGLP TPEIPMTEAV EAVAMVGGQL QAFWKHGVQV 720

WALGSDQLLQ ELRDPTLTFR LLGLPRPVVV ETRPVDDPTA PSNLYI 766

Nucleotide Sequence
(FASTA)

TTCTCCAACC ACTTCAGGTT GCAGAAACTC TGGATCTGCA TGGAATTCTG CGGGGCTGGT 60

TCTCTCCAGG ACATCTACCA AGTGACAGGC TCCTTGTCAG AGCTCCAGAT TAGCTATGTC 120

TGCCGGGAAG TGCTCCAGGG ACTGGCCTAT CTGCACTCAC AGAAGAAGAT ACACCGGGAC 180

ATCAAGGGAG CTAACATCCT CATCAATGAT GCTGGGGAGG TCAGATTGGC TGACTTTGGC 240

ATCTCGGCCC AGATCGGGGC GACGCTGGCC AGACGCCTCT CTTTCATTGG CACACCCTAC 300

TGGAGGGCTC CAGAAGTGGC AGCCGTGCCC AAGGGAGGAT ACAATGAGCT GTGTGACTTT 360

TGGTCCCTGG GCATCACGGC CATCGAGCTG GCGGAGCTAC AGCCACCGCT CTTTGACGTG 420

CACCCTCTCA GAGTTCTCTT CCTCATGACC AAGAGTGGCT ACCAGCCTCC CCGACTGAAG 480

GAAAAAGGCA AATGGTCGGC TGCCTTCCAC AACTTCGTCA AAGTCACCCT GACTAAAAGC 540

CCCAAGAAAC GACCCGGCGC CACCAAGATG CTCAGTCATC AACTGGTATC CCAGCCTGGG 600

CTGAACCGAG GCCTCATCCT AGATCTTCTT GACAAACTGA AGAATCCCGG AAAAGGACCC 660

TCCATCGGGG ACATTGAGGA TGAGGAGCCC GAGCTACCCC CTGCTGTCCC CCGGCGGATC 720

AGATCCACAC ACCGCTCCAG CTCTCTGGGG ATCCCCGATG CAGACTGCTG TCGCTCGCCT 780

ACAGCCCACC AGAGACCTCA AGAGCAGCAG CCCCAGGTCA GGGACCCCAG GGAGGGCGCT 840

CCAGCTCCTA CCTTCCTTCT AGTTATTAAT CCTTTAATCC TCAGTTCCAG CCAGAATCAG 900

TCACCGTTAA GCCTCCTCAC CTCAAACCCC AGTCCCAGGC CTCCAGCCCA GAACCACACT 960

GTCTTCCCTG AGTCCTTGCT TCCCAGGCCC CCAGCGATTG AGCCCATCTT TGTGTTTCAG 1020

CCCCACTCTT GCAGAGGACA CACCTCCTCC ACTGCCCCCC AAGATGCCGG GATACTGGGC 1080

TCTCCAGGGC AGGGAGTCGG GGAGACCAGG ATCATGGCTA CATTGGCATC TGGAAGTGGC 1140

ATCCCTCAAC ATCAGGACGA GGGTCCTGGG GGTATAGGGG ATGATGGGCA GCTGAGCCCG 1200

GGGGTGCTTG TCCGGTGTGC CAGTGGACCT CCAATAAACG ATCTGCTGCC GGGGTCCCCG 1260

CGGCCTGCCC AGGGATGCGC CCTTCTGGTA AAGCTATTCA ATGGCTGTCC CCTCCGAATC 1320

CACAGCACAG CCGCCTGGAC ACACCCCTCC ACTAAGGACC AGCACCTGCT CCTGGGGGCA 1380

GAGGAAGGCA TCTTCATCCT GAATCGGAAT CTCCCAGATC ATCCCCTGCC TCCTGGGGGG 1440

CAGAGGAAAG GATCTTTCAT TCCTGAAATC GGGAATGACA GGAAGTCCCC TCTGGAGAAT 1500

GGAAGAAAGA CCCCCCACCT GTATTCTCAT AGCATCCTGG GCCTGCTAGA ACGGAAAGAG 1560

ACCAAAGCAG GAAATCCGAT CGCTCACATT AGCCCCCACC GGCTACTGGC AAGGAAGAAC 1620

ATGGTTTCCA CCAAGATCCA GGACACCAAA GGCTGCCGGG CTTGCTGTGT GGCGGAGGGT 1680

TCGAGCTCTG GGGGCCCATT CCTGTGCGGG GCATTGGAGA CGTCCGTTGT CCTGCTTCAG 1740

TGGTACCAGC CCATGAACAA ATTCCTGCTC GTCCGGCAGG TGCTGTTCCC ACTGCCGACG 1800

CCTCTGTCCG TGTTCGCGCT GCTGACCGGG CCAGGTTCTG AGCTGCCCTC TGTGTGCATC 1860

GGCGTGAGCC CCGGGCGGTC GGGGAAGTCG GTGCTCTTCC ACACTGTGCG TTTTGGCGCG 1920

CTCTCCTGCT GGCTGGGCGA GATGAGCACC AAAACAGAGC ACAAGGGACC AGTGCAGGTG 1980

ACCCAGGTAG AGGAGGATAT GGTGATGGTG TTGATGGACG GCTCTCTGAA GCTAGTGACC 2040

CCGGAAGGGA TACCAGTCCG GGGACTTCCC ACACCTGAGA TCCCCATGAC AGAAGCAGTG 2100

GAGGCCGTGG CTATGGTTGG AGGTCAGCTT CAGGCCTTCT GGAAGCATGG AGTGCAGGTG 2160

TGGGCTCTAG GCTCGGATCA GCTGCTACAG GAACTGAGAG ACCCTACCCT CACTTTTCGT 2220

CTGCTCGGCT TGCCCAGGCC TGTAGTGGTG GAGACACGCC CAGTGGATGA TCCTACTGCT 2280

CCCAGCAACC TCTACATC 2298

Domain Profile

S: 66    lkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdik  125

         ++ ++lw++me++ +Gsl+d+++  ++ +l+E qi+y++revl++L+ylHs+k+iHrdik

Q: 5     FRLQKLWICMEFCGAGSLQDIYQ--VTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIK  62

         56789******************..9**********************************

S: 126   akniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiws  185

         ++niL+++ geV+L+dfg++aq+ +t ++r +++gtpyw APEv a+ + gY+e +D ws

Q: 63    GANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWRAPEVAAVPKGGYNELCDFWS  122

         ************************************************************

S: 186   lGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpe  243

         lGItaielae +pP++d++pl++l++++k+   pp+lk+k k+s +f++fv+  l+k+p+

Q: 123   LGITAIELAELQPPLFDVHPLRVLFLMTKSGyqPPRLKEKGKWSAAFHNFVKVTLTKSPK  182

         ****************************998889**************************

S: 244   kRpsasellkhk  255

         kRp a+++l+h+

Q: 183   KRPGATKMLSHQ  194

         ***********8

Domain Sequence
(FASTA)

FRLQKLWICM EFCGAGSLQD IYQVTGSLSE LQISYVCREV LQGLAYLHSQ KKIHRDIKGA 60

NILINDAGEV RLADFGISAQ IGATLARRLS FIGTPYWRAP EVAAVPKGGY NELCDFWSLG 120

ITAIELAELQ PPLFDVHPLR VLFLMTKSGY QPPRLKEKGK WSAAFHNFVK VTLTKSPKKR 180

PGATKMLSHQ 190

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Cavia porcellus"; ?>Equus caballus"; ?>Ictidomys tridecemlineatus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013