EKS-CAJ-00065
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAJ-00065
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK351.95.2E-10513300288
StatusUnreviewed
Ensembl ProteinENSCJAP00000025546
UniProt AccessionF6YF92;
Protein Name
Protein Synonyms/Alias
Gene NameCDK6
Gene Synonyms/Alias CDK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCJAG00000013902ENSCJAP00000025547ENSCJAT00000027002
ENSCJAG00000013902ENSCJAP00000025546ENSCJAT00000027001
OrganismCallithrix jacchus
Functional Description
Protein Length326
Protein Sequence
(FASTA)
MEKDGLSRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 60
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSNGQIK LADFGLARIY SFQMALTSVV 180
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 240
EDWPRDVALP RQAFHAKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF 300
QDLERGRENL DSHLPPSQNT SEMNTA 326
Nucleotide Sequence
(FASTA)
ATGGAGAAGG ACGGCCTGAG CCGCGCGGAC CAGCAGTACG AATGCGTAGC GGAGATCGGG 60
GAGGGCGCCT ATGGGAAGGT GTTCAAGGCC CGAGACTTGA AGAACGGAGG CCGTTTCGTG 120
GCGTTGAAGC GCGTGCGGGT GCAGACCGGC GAGGAGGGCA TGCCGCTCTC CACCATCCGC 180
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTCGAACACC CCAACGTGGT CAGGTTGTTT 240
GATGTGTGCA CAGTGTCACG AACTGACAGA GAAACCAAAC TAACTTTAGT GTTTGAACAT 300
GTCGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AGCCTGGAGT GCCCACTGAA 360
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTTCTTCA TTCACACCGA 420
GTAGTGCATC GCGATCTAAA ACCACAAAAC ATTCTGGTGA CCAGCAATGG ACAAATAAAA 480
CTCGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTCCAGA TGGCTCTAAC TTCAGTGGTC 540
GTCACGCTGT GGTACAGAGC GCCCGAAGTC TTGCTCCAGT CCAGCTACGC CACCCCCGTG 600
GATCTCTGGA GTGTTGGCTG CATATTTGCA GAAATGTTTC GTAGAAAGCC TCTTTTTCGT 660
GGAAGTTCAG ATGTCGATCA ACTAGGAAAA ATCTTGGACG TAATTGGACT CCCAGGAGAA 720
GAAGACTGGC CTAGAGATGT TGCCCTTCCC AGGCAGGCTT TTCATGCAAA ATCTGCCCAA 780
CCAATTGAGA AGTTTGTGAC AGATATTGAT GAACTAGGCA AAGACCTACT TCTGAAGTGT 840
TTGACATTTA ACCCAGCCAA AAGAATATCT GCCTACAGCG CCCTGTCTCA CCCATACTTC 900
CAGGACCTGG AGAGGGGCAG AGAAAACCTG GATTCCCACC TGCCTCCCAG CCAGAACACC 960
TCCGAGATGA ATACAGCCTG A 981
Domain Profile
S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56
         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++rE+++l++l   +
Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLetfE  72
         899*****************888999*****************************98889
S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112
         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k +++qll+g
Q: 73    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG  132
         ************99855569****************************************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172
         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L
Q: 133   LDFLHSHRVVHRDLKPQNILVTSNGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191
         *****************************************99.****************
S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232
         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +i++++g p e++wp+   lp
Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP  250
         *88.5*******************************************************
S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         +   +f+ k+++ +++ v++++e + dll k+l+++p+kRisa +al+h+yf
Q: 251   RQ--AFHAKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF  300
         95..59999999***************************************9
Domain Sequence
(FASTA)
YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV AVLRHLETFE 60
HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMFQLLRG 120
LDFLHSHRVV HRDLKPQNIL VTSNGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180
QSSYATPVDL WSVGCIFAEM FRRKPLFRGS SDVDQLGKIL DVIGLPGEED WPRDVALPRQ 240
AFHAKSAQPI EKFVTDIDEL GKDLLLKCLT FNPAKRISAY SALSHPYF 288
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00064
EKS-ANC-00063
EKS-BOT-00069
EKS-CAF-00073
EKS-CAP-00067
EKS-CII-00028
EKS-CIS-00069
EKS-DAR-00082
EKS-DRM-00032
EKS-EQC-00067
EKS-FEC-00067
EKS-GAM-00030
EKS-GAG-00055
EKS-GAA-00084
EKS-GOG-00073
EKS-HOS-00071
EKS-LAC-00069
EKS-LOA-00067
EKS-MAM-00067
EKS-MEG-00052
EKS-MOD-00066
EKS-MUM-00071
EKS-MUP-00071
EKS-MYL-00072
EKS-NOL-00064
EKS-OCP-00043
EKS-ORN-00088
EKS-ORA-00061
EKS-ORC-00065
EKS-ORL-00078
EKS-OTG-00072
EKS-PAT-00061
EKS-PES-00062
EKS-PEM-00037
EKS-POA-00064
EKS-PRC-00041
EKS-RAN-00064
EKS-SOA-00030
EKS-TAG-00057
EKS-TAR-00088
EKS-TEN-00090
EKS-TUT-00063
EKS-XET-00063
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013