EKS-CAJ-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.9	1.6E-110	89	373	285

Status

Reviewed

Ensembl Protein

ENSCJAP00000026123

UniProt Accession

B0VXE8;

Protein Name

Cyclin-dependent kinase 14

Protein Synonyms/Alias

Cell division protein kinase 14;

Gene Name

CDK14

Gene Synonyms/Alias

CDK14; PFTK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000014175	ENSCJAP00000026131	ENSCJAT00000027614
ENSCJAG00000014175	ENSCJAP00000043575	ENSCJAT00000060883
ENSCJAG00000014175	ENSCJAP00000026123	ENSCJAT00000027606
ENSCJAG00000014175	ENSCJAP00000042112	ENSCJAT00000062340

Organism

Callithrix jacchus

Functional Description

Serine/threonine-protein kinase involved in the controlof the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).

Protein Length

423

Protein Sequence
(FASTA)

MSTRNCQGMD SVIKPLDTIP EDKKVRVQRT QSTFDPFEKP TNQVKRVHSE NNACINFKTS 60

STGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI 120

RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG 180

GLHPDNVKLF LFQLLRGLSY IHQRYILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH 240

TYSNEVVTLW YRPPDVLLGS TEYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300

LVLGTPNEDT WPGVHSLPHF KPERFTLYSS KNLRQAWNKL SYVNHAEDLA SKLLQCSPKN 360

RLSAQAALSH EYFSDLPPRL WELTDMSSIF TVPNVRLQPE AGESMRAFGK NNSYGKSLSN 420

SKH 423

Nucleotide Sequence
(FASTA)

ATGTCTACAC GGAATTGCCA GGGAATGGAC TCAGTGATCA AACCCCTGGA CACAATTCCT 60

GAGGATAAAA AAGTCAGAGT TCAGAGGACA CAGAGCACTT TTGACCCATT TGAGAAACCA 120

ACTAATCAAG TAAAGAGGGT GCATTCTGAG AACAATGCTT GCATTAACTT TAAGACCTCC 180

TCCACTGGCA AAGAGTCACC TAAAGTTAGG CGGCACTCCA GCCCCAGCTC GCCAACAAGT 240

CCCAAATTTG GAAAAGCTGA CTCATATGAA AAACTGGAAA AATTAGGGGA AGGATCTTAT 300

GCTACAGTAT ACAAAGGGAA AAGCAAGGTA AATGGGAAGT TGGTAGCTCT GAAGGTGATC 360

AGGCTGCAAG AAGAAGAAGG GACACCTTTC ACAGCTATCA GGGAAGCTTC TCTATTAAAA 420

GGACTGAAAC ATGCTAACAT AGTGCTACTT CATGACATCA TCCATACCAA GGAGACGCTG 480

ACACTTGTGT TTGAATATGT GCACACTGAT TTATGTCAGT ACATGGACAA GCACCCTGGG 540

GGGCTGCATC CAGATAATGT GAAGTTGTTT TTATTTCAGT TGCTGCGGGG TCTGTCTTAC 600

ATCCACCAGC GTTATATTTT GCACAGAGAC CTGAAACCAC AGAACCTTCT GATCAGTGAC 660

ACGGGGGAGT TGAAGCTAGC AGATTTCGGT CTTGCAAGAG CAAAATCCGT CCCTAGCCAC 720

ACATACTCCA ACGAAGTGGT TACCCTGTGG TACAGACCTC CAGATGTCCT TCTAGGCTCA 780

ACAGAATATT CCACCTGCCT TGACATGTGG GGAGTAGGTT GCATCTTTGT TGAAATGATC 840

CAAGGAGTTG CTGCTTTTCC AGGAATGAAA GACATTCAGG ATCAACTTGA ACGAATATTT 900

CTGGTTCTTG GAACGCCAAA TGAGGACACA TGGCCTGGAG TTCATTCTTT ACCACATTTT 960

AAGCCAGAAC GCTTTACCCT GTACAGCTCT AAAAACCTTA GACAAGCGTG GAATAAGCTC 1020

AGCTATGTGA ACCATGCAGA GGATCTGGCC TCCAAGCTCC TACAATGTTC CCCAAAGAAC 1080

AGACTATCGG CACAGGCTGC CTTGAGCCAC GAGTACTTTA GTGACCTGCC CCCACGGCTA 1140

TGGGAACTCA CCGATATGTC TTCTATTTTT ACTGTCCCAA ATGTGAGATT GCAACCAGAA 1200

GCTGGAGAAA GCATGCGGGC CTTTGGGAAA AACAATAGTT ACGGCAAAAG TCTATCAAAC 1260

AGCAAACACT GA 1272

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 89    YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  147

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++++vk +l+qll+gl+y+H++

Q: 148   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY  205

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 206   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  265

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f

Q: 266   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpERF  325

         ************************99679***************************9999

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         + +++k+l++ ++kl+  ++a dl +kll+++pk+R+sa++al+h+yf

Q: 326   TLYSSKNLRQAWNKLSyvNHAEDLASKLLQCSPKNRLSAQAALSHEYF  373

         99**********99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPERFTLY 240

SSKNLRQAWN KLSYVNHAED LASKLLQCSP KNRLSAQAAL SHEYF 285

Keyword

ATP-binding; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0051301	; P:cell division
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013