EKS-CAJ-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	2.1E-95	169	406	238

Status

Unreviewed

Ensembl Protein

ENSCJAP00000027346

UniProt Accession

F7CVY6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000014818	ENSCJAP00000044507	ENSCJAT00000057747
ENSCJAG00000014818	ENSCJAP00000047269	ENSCJAT00000059392
ENSCJAG00000014818	ENSCJAP00000027346	ENSCJAT00000028908
ENSCJAG00000014818	ENSCJAP00000034671	ENSCJAT00000036615
ENSCJAG00000014818	ENSCJAP00000051303	ENSCJAT00000054049

Organism

Callithrix jacchus

Functional Description

Protein Length

965

Protein Sequence
(FASTA)

MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLEDQQEKGM ARTELVESMN 60

SPITTTVLTS VSEDSRDQFE NSVLQLREHD ESEMVVSQGN SNTVDGESTS GTEDIKIQFS 120

RSGSGSGGFL EGLFGCLRPV WNIIGKAYST DYKLQQQDTW EVPFEEISEL QWLGSGAQGA 180

VFLGKFRAEE VAIKKVREQN ETDIKHLRKL KHPNIIAFKG VCTQAPCYCI IMEYCAHGQL 240

YEVLRAGRKI TPRLLVDWST GIASGMNYLH LHKIIHRDLK SPNVLVTHTD AVKISDFGTS 300

KELSDKSTKM SFAGTVAWMA PEVIRNEPVS EKVDIWSFGV VLWELLTGEI PYKDVDSSAI 360

IWGVGSNSLH LPVPSTCPDG FKILMKQTWQ SKPRNRPSFR QTLMHLDIAS ADVLATPQET 420

YFKSQAEWRE EVKKHFEKIK SEGTCIHRLD EELIRRRREE LRHALDIREH YERKLERANN 480

LYMELSAIML QLEMREKELI KREQAVEKKY PGTYKRHPVR PIIHPNAMEK LMKRKGVPHK 540

SGMQTKRPDL LRSEGIPTTE VAPMASPLSG SPKTSTSSSK SRYRSKPRHR RGNSRGSHSD 600

FASILKSQPA QENSPHPSYL HQAQSQYPSI HHHDPLQQQY QQPPPAMSQS HHPRLNIHGQ 660

DIAACANNLR YFGPAAALRS PLSNHAQRQL PGSSPDLIST AMAADGWRSS EPDKGQTGPW 720

SCCQADPYDP CLQCRPEQYG SLNVPSAEPV GRSPDLSKSP AHNPLSENAQ SSEKMEEKEF 780

SSCRSESSLG TTQLITPPVL PRKTRPLPKS GDDSSEEEEG EVDSEVEFPR RQRPHRCISS 840

CQSCSTFSSE NFSVSDGEEG NTSDHSNSPD ELADKLEDRL AEKLDDLLSQ TPEIPIDISS 900

HSDGLSDKEC AVRRVKTQMS LGKLCVEERG YENPLQFEEL DCDSSDGECS DATVRTDKHY 960

SSATW 965

Nucleotide Sequence
(FASTA)

ATGGCCAACT TTCAGGAGCA CCTGAGCTGC TCCTCTTCTC CACACTTACC CTTCAGTGAA 60

AGCAAAACCT TCAATGGACT ACAAGATGAA CTCACAGCCA TGGGGAACCA CCCTTCTCCC 120

AAGCTCGAGG ACCAGCAGGA AAAGGGGATG GCACGAACAG AGCTAGTCGA GAGCATGAAC 180

AGCCCCATCA CCACAACAGT GTTGACAAGC GTAAGTGAGG ATTCCAGGGA CCAGTTTGAG 240

AACAGCGTTC TTCAGCTAAG GGAACACGAT GAATCAGAGA TGGTGGTGTC TCAGGGGAAC 300

AGCAACACAG TGGACGGAGA GAGCACAAGC GGAACTGAAG ACATCAAGAT TCAGTTCAGC 360

AGGTCAGGCA GTGGCAGCGG TGGGTTTCTT GAAGGACTCT TTGGATGTTT AAGGCCTGTA 420

TGGAATATCA TTGGGAAAGC ATATTCCACT GACTACAAAT TGCAGCAGCA AGATACTTGG 480

GAAGTGCCAT TTGAGGAGAT CTCAGAGCTA CAGTGGCTGG GTAGTGGAGC CCAAGGAGCT 540

GTCTTCTTGG GCAAGTTCCG AGCGGAAGAG GTGGCCATCA AGAAAGTGAG AGAACAGAAT 600

GAGACGGATA TCAAGCATTT GAGGAAGTTG AAGCACCCTA ACATCATCGC ATTCAAGGGT 660

GTGTGTACTC AGGCCCCATG TTACTGTATC ATCATGGAAT ACTGTGCCCA CGGACAACTC 720

TATGAGGTCT TGCGAGCCGG CAGGAAGATC ACGCCTCGAT TGCTGGTAGA CTGGTCCACA 780

GGAATTGCAA GTGGAATGAA TTATTTGCAC CTCCATAAAA TTATTCATCG TGATCTCAAA 840

TCACCTAATG TTTTAGTGAC CCACACAGAC GCAGTAAAAA TTTCAGATTT TGGTACGTCT 900

AAGGAACTCA GTGATAAAAG TACCAAGATG TCATTTGCTG GCACGGTGGC CTGGATGGCG 960

CCAGAGGTGA TACGAAATGA ACCTGTCTCT GAAAAGGTGG ATATATGGTC TTTCGGAGTG 1020

GTGCTTTGGG AGCTGCTGAC AGGAGAGATC CCTTACAAAG ATGTAGATTC TTCAGCAATT 1080

ATCTGGGGCG TTGGAAGCAA TAGCCTACAC CTCCCAGTTC CTTCCACTTG CCCTGATGGA 1140

TTCAAAATCC TTATGAAACA GACATGGCAG AGTAAACCTC GAAACCGACC TTCTTTTCGG 1200

CAGACGCTCA TGCATTTAGA TATTGCCTCT GCAGATGTAC TTGCCACCCC ACAAGAAACT 1260

TACTTCAAGT CTCAGGCTGA ATGGAGAGAA GAAGTGAAAA AACACTTTGA GAAGATCAAA 1320

AGTGAAGGAA CTTGTATACA CCGGTTAGAT GAAGAACTGA TTCGAAGGCG CAGAGAAGAG 1380

CTCAGGCATG CGCTGGATAT TCGTGAACAC TATGAGCGAA AGCTTGAGCG GGCGAATAAT 1440

TTATACATGG AATTGAGTGC CATCATGCTA CAGCTGGAAA TGCGGGAGAA GGAGCTTATT 1500

AAGCGTGAGC AAGCAGTGGA AAAGAAGTAT CCGGGGACCT ACAAACGACA CCCTGTTCGT 1560

CCAATAATCC ACCCCAATGC CATGGAGAAG CTCATGAAAA GGAAGGGAGT GCCTCACAAA 1620

TCTGGGATGC AGACCAAACG ACCAGACTTG TTGAGATCAG AAGGGATCCC CACTACAGAA 1680

GTGGCTCCCA TGGCATCCCC TTTGTCCGGA AGCCCCAAAA CGTCCACCTC TAGCAGCAAG 1740

AGCCGATATC GAAGCAAACC ACGCCACCGC CGAGGGAATA GCAGAGGCAG CCATAGTGAC 1800

TTTGCCTCAA TCTTGAAAAG CCAGCCAGCC CAGGAAAATT CACCCCATCC CTCTTACCTA 1860

CACCAAGCTC AATCCCAGTA CCCTTCTATC CATCACCATG ATCCTCTGCA GCAGCAATAC 1920

CAGCAGCCCC CTCCTGCCAT GTCCCAGAGT CACCATCCCA GACTCAACAT TCATGGACAG 1980

GACATTGCAG CCTGCGCCAA CAACCTGAGG TATTTTGGCC CAGCAGCAGC CCTGCGGAGC 2040

CCACTCAGCA ACCATGCCCA GAGACAGCTT CCTGGCTCGA GCCCTGACCT CATCTCCACA 2100

GCCATGGCTG CAGATGGCTG GAGAAGTTCT GAGCCTGACA AGGGCCAAAC TGGTCCCTGG 2160

AGCTGTTGCC AGGCTGACCC TTATGACCCC TGCCTTCAGT GCAGACCGGA ACAGTATGGA 2220

TCCTTAAACG TACCCTCTGC TGAGCCAGTG GGGAGGAGCC CTGACCTTTC CAAGTCACCA 2280

GCACACAATC CTCTCTCGGA AAATGCCCAG AGTTCTGAGA AAATGGAAGA AAAAGAATTC 2340

AGCAGCTGTA GGTCTGAGTC ATCCCTCGGC ACCACTCAGC TCATCACCCC TCCAGTGCTA 2400

CCTCGAAAAA CAAGGCCTCT GCCAAAGAGT GGAGATGACT CCTCAGAAGA GGAAGAAGGG 2460

GAAGTAGATA GTGAAGTTGA ATTTCCACGA AGACAGAGGC CCCATCGCTG TATCAGCAGC 2520

TGCCAGTCAT GTTCAACCTT TAGCTCTGAG AATTTCTCTG TGTCTGATGG AGAGGAGGGA 2580

AATACCAGTG ACCACTCAAA CAGTCCTGAT GAGTTAGCTG ATAAACTTGA AGACCGCTTG 2640

GCGGAGAAGC TAGACGACCT GCTGTCCCAG ACGCCGGAGA TTCCCATTGA CATATCCTCA 2700

CACTCAGATG GGCTCTCTGA CAAGGAGTGT GCTGTGCGCC GTGTGAAGAC TCAGATGTCT 2760

CTGGGCAAGC TGTGTGTGGA AGAACGTGGC TATGAGAATC CTTTGCAGTT TGAAGAACTG 2820

GACTGTGACT CTTCAGATGG GGAGTGTTCT GATGCCACAG TTAGGACCGA TAAACACTAC 2880

AGCTCTGCTA CCTGGTGA 2898

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 169   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  219

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 220   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  274

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 275   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  333

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 334   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  393

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 394   RNRPSFRQTLMHL  406

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013