EKS-CAJ-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.8	4.1E-104	16	273	258

Status

Unreviewed

Ensembl Protein

ENSCJAP00000049392

UniProt Accession

F7GGD6;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000014920	ENSCJAP00000051050	ENSCJAT00000056049
ENSCJAG00000014920	ENSCJAP00000048683	ENSCJAT00000061047
ENSCJAG00000014920	ENSCJAP00000027674	ENSCJAT00000029247
ENSCJAG00000014920	ENSCJAP00000049392	ENSCJAT00000053932

Organism

Callithrix jacchus

Functional Description

Protein Length

872

Protein Sequence
(FASTA)

MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 120

LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 240

KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 300

DDDDPEPLVA VPHRIPSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH ELDLQLEYGQ 360

GHQGSYFLGA NKSLLKSVEE ELHQRGHVAH LEDDEGDDDD SKHSTLKAKV PPPLPPKPKS 420

VFIPQETLSA EDDNQGTIKR CPLSGSPAKP SQVPPRPPPP RLPPQKPVAL GNGVSSFQLN 480

GERDGSLHQQ NEHRGTNLSR KEKKDVPKPI SNGLPPTPKV HMGACFSKVF NGCPLKIHCA 540

SSWINPDTRD QYLIFGAEEG IYTLNLNELH ETSMEQLFPR RCTWLYVMNN CLLSISGKAS 600

QLYSHNLPGL FDYARQMQKL PVAIPAHKLP DRILPRKFSV STKIPETKSC QKCCVVRNPY 660

TGHKYLCGAL QTSIVLLEWV EPMQKFMLIK HIDFPIPCPL RMFEMLVVPE QEYPLVCVGV 720

GRGRDFNQVV RFETVNPNST SSWFTESDTP QTNVTHVTQL ERDTILVCLD CCIKIVNLQG 780

RLKSSRKLSS ELTFDFQIES IVCLQDSVLA FWKHGMQGRS FRSNEVTQEI SDSTRIFRLL 840

GSDRVVVLES RPTDNPTANS NLYILAGHEN SY 872

Nucleotide Sequence
(FASTA)

ATGAACCCCG GCTTCGATCT GTCCCGCCGG AACCCGCAGG AGGACTTCGA GCTGATTCAG 60

CGCATCGGCA GCGGCACCTA CGGCGACGTC TACAAGGCAC GGAATGTTAA CACTGGTGAA 120

TTAGCAGCAA TTAAAGTAAT AAAATTGGAA CCAGGAGAAG ACTTTGCAGT TGTGCAGCAA 180

GAAATTATTA TGATGAAAGA CTGTAAACAC CCAAATATTG TTGCTTATTT TGGAAGCTAT 240

CTCAGACGAG ATAAGCTTTG GATTTGCATG GAGTTTTGTG GAGGTGGTTC TTTACAGGAT 300

ATTTATCACG TAACTGGACC TCTGTCAGAG CTGCAGATTG CATATGTTAG CAGAGAAACA 360

CTGCAGGGAT TATATTATCT TCACAGTAAA GGAAAAATGC ACAGAGACAT AAAGGGAGCT 420

AACATTCTAT TAACGGATAA TGGTCATGTG AAATTGGCTG ATTTTGGAGT ATCTGCACAG 480

ATAACAGCTA CAATTGCCAA ACGGAAGTCT TTCATTGGCA CACCATATTG GATGGCTCCA 540

GAAGTCGCAG CTGTTGAGAG GAAGGGGGGT TACAATCAAC TCTGTGATCT CTGGGCAGTG 600

GGAATCACTG CCATAGAACT TGCAGAGCTT CAGCCTCCTA TGTTTGACTT ACACCCAATG 660

AGAGCATTAT TTCTAATGAC AAAAAGCAAT TTTCAACCTC CTAAACTAAA GGATAAAATG 720

AAGTGGTCAA ATAGTTTTCA TCATTTTGTG AAAATGGCAC TTACCAAAAA TCCAAAAAAA 780

AGACCTACTG CTGAAAAATT ATTACAGCAT CCTTTTGTAA CACAACATTT GACACGGTCT 840

TTGGCAATCG AGCTGTTGGA TAAAGTAAAT AATCCAGATC ATTCCACTTA CCATGATTTC 900

GATGATGATG ATCCTGAGCC TCTTGTTGCT GTACCACATA GAATTCCCTC AACAAGTAGA 960

AATGTGAGAG AAGAGAAAAC ACGCTCAGAG ATAAACTTTG GCCAAGTGAA ATTTGATCCA 1020

CCCTTAAGAA AGGAGACAGA ACCACATCAT GAACTTGATC TACAACTGGA ATATGGACAG 1080

GGACATCAAG GTAGTTACTT TTTAGGTGCA AACAAGAGTC TTCTCAAGTC TGTTGAAGAA 1140

GAATTGCATC AGCGAGGACA CGTGGCACAT TTAGAAGATG ATGAAGGGGA TGATGATGAC 1200

TCTAAACATT CAACTCTGAA AGCAAAAGTT CCACCTCCTT TACCACCAAA GCCTAAGTCT 1260

GTCTTCATAC CACAGGAAAC GCTTTCCGCT GAGGATGATA ATCAAGGAAC AATCAAGAGA 1320

TGTCCCTTGT CAGGGAGCCC AGCAAAGCCA TCCCAAGTTC CACCTAGACC ACCACCTCCC 1380

AGATTACCCC CACAAAAACC TGTTGCCTTA GGAAATGGAG TGAGCTCCTT CCAGTTAAAT 1440

GGTGAACGAG ATGGCTCATT ACATCAACAG AATGAACATA GAGGCACGAA CCTTTCAAGA 1500

AAAGAAAAGA AAGATGTACC AAAGCCTATT AGTAATGGTC TTCCTCCAAC ACCTAAAGTG 1560

CATATGGGTG CATGTTTTTC AAAAGTTTTT AATGGGTGTC CCTTGAAAAT TCACTGTGCA 1620

TCATCGTGGA TAAACCCAGA TACAAGAGAT CAGTACTTGA TCTTTGGTGC AGAGGAAGGG 1680

ATTTATACCC TGAATCTTAA TGAACTTCAT GAAACATCAA TGGAACAGCT ATTCCCTCGA 1740

AGGTGTACGT GGTTGTATGT AATGAACAAT TGCTTGCTAT CAATATCTGG TAAAGCTTCT 1800

CAGCTTTATT CCCATAATTT ACCAGGGCTT TTTGATTATG CAAGACAAAT GCAAAAGTTA 1860

CCTGTTGCTA TTCCAGCACA CAAACTCCCT GACAGAATAC TGCCAAGGAA ATTTTCTGTA 1920

TCAACAAAAA TCCCTGAAAC CAAGTCGTGT CAGAAGTGTT GTGTTGTAAG AAATCCTTAT 1980

ACAGGCCATA AATACCTATG TGGAGCACTT CAGACTAGCA TTGTTCTACT GGAATGGGTT 2040

GAACCAATGC AGAAATTTAT GTTAATTAAG CACATAGATT TTCCTATACC ATGTCCACTT 2100

AGAATGTTTG AAATGCTGGT AGTTCCTGAA CAGGAGTACC CTTTAGTTTG CGTTGGTGTC 2160

GGTAGAGGTA GAGACTTCAA CCAGGTGGTT CGATTCGAGA CGGTCAATCC AAATTCTACC 2220

TCTTCATGGT TTACAGAATC AGATACCCCA CAGACAAATG TTACTCATGT AACCCAGCTG 2280

GAGAGAGATA CCATTCTTGT ATGCTTGGAC TGTTGTATAA AAATAGTAAA TCTCCAAGGA 2340

AGATTAAAAT CTAGCAGAAA ATTATCATCA GAACTCACCT TTGATTTCCA GATTGAATCA 2400

ATAGTTTGCC TACAAGACAG TGTGCTAGCT TTCTGGAAAC ACGGAATGCA AGGTAGAAGT 2460

TTTAGATCTA ATGAGGTAAC ACAAGAAATT TCAGACAGCA CAAGAATTTT CAGGCTGCTT 2520

GGATCTGACA GGGTCGTGGT TTTGGAAAGT AGGCCAACTG ATAACCCCAC AGCAAATAGC 2580

AATTTATACA TCCTGGCGGG TCATGAAAAC AGTTACTGA 2619

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++

Q: 76    YFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +

Q: 194   LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMA  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHPNIVA 60

YFGSYLRRDK LWICMEFCGG GSLQDIYHVT GPLSELQIAY VSRETLQGLY YLHSKGKMHR 120

DIKGANILLT DNGHVKLADF GVSAQITATI AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DLWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKMKWSNS FHHFVKMALT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013