EKS-CAJ-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	7.2E-136	208	495	288

Status

Unreviewed

Ensembl Protein

ENSCJAP00000028316

UniProt Accession

F7B7W8;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000015359	ENSCJAP00000028316	ENSCJAT00000029922
ENSCJAG00000015359	ENSCJAP00000028325	ENSCJAT00000029931

Organism

Callithrix jacchus

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MIDGVMILPV LIMIAFPSPS MEDEKPKVSP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60

DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQSF 120

HLEIGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180

ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420

NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480

NPSARLTALR IKKTLTKIDN SLDKLKTDC 509

Nucleotide Sequence
(FASTA)

ATGATAGATG GAGTGATGAT TCTTCCTGTG CTTATAATGA TTGCTTTCCC CTCCCCTAGT 60

ATGGAAGATG AGAAGCCCAA GGTCAGCCCC AAACTCTACA TGTGTGTGTG TGAAGGCCTT 120

TCCTGCGGTA ATGAGGACCA CTGTGAAGGC CAGCAGTGCT TTTCCTCACT GAGCATCAAT 180

GATGGCTTCC ACGTCTACCA GAAAGGCTGC TTCCAGGTTT ATGAGCAGGG AAAGATGACC 240

TGTAAGACCC CACCATCCCC TGGCCAAGCT GTGGAGTGCT GCCAAGGGGA CTGGTGTAAT 300

AGGAACATCA CGGCACAGCT GCCCACAAAA GGAAAATCCT TCCCTGGAAC ACAGAGTTTC 360

CACTTGGAGA TCGGCCTCAT TATTCTCTCT GTAGTGTTCG CAGTATGTCT TTTAGCCTGC 420

TTGCTGGGAG TGGCACTCCG AAAATTTAAA AGACGCAACC AAGAACGTCT CAATCCCCGA 480

GATGTGGAGT ATGGCACCAT TGAAGGGCTT ATCACCACCA ATGTCGGAGA CAGCACTTTG 540

GCAGATTTAT TGGATCATTC ATGTACATCA GGAAGTGGCT CTGGTCTTCC CTTTCTGGTA 600

CAAAGAACAG TGGCTCGCCA GATTACACTG TTGGAGTGTG TCGGGAAAGG CAGGTATGGT 660

GAAGTGTGGA GGGGCAGTTG GCAAGGGGAA AATGTTGCTG TGAAGATCTT TTCCTCCCGT 720

GATGAGAAGT CATGGTTCAG GGAAACAGAA TTGTACAACA CTGTGATGCT GAGGCATGAA 780

AATATCTTAG GTTTTATTGC TTCAGACATG ACATCAAGAC ACTCCAGTAC CCAGCTGTGG 840

TTAATTACAC ATTATCATGA AATGGGATCT TTGTACGACT ATCTTCAGCT TACTACTCTG 900

GATACAGTTA GCTGCCTTCG AATAGTGCTG TCCATAGCGA GTGGTCTTGC ACATTTGCAC 960

ATAGAGATAT TCGGGACCCA AGGGAAACCA GCCATTGCCC ATCGAGATTT AAAGAGCAAA 1020

AACATTCTGG TTAAGAAGAA TGGACAGTGT TGCATAGCAG ATTTGGGCTT GGCAGTCATG 1080

CATTCCCAGA GCACCAATCA GCTTGATGTG GGGAACAATC CCCGTGTGGG CACAAAGCGC 1140

TACATGGCCC CCGAAGTTCT AGATGAAACC ATCCAGGTGG ATTGTTTTGA TTCCTATAAA 1200

AGGGTCGATA TTTGGGCCTT TGGACTTGTT TTGTGGGAAG TGGCCAGGCG GATGGTGAGC 1260

AATGGTATAG TGGAGGATTA CAAGCCACCA TTCTACGATG TGGTTCCCAA TGACCCAAGT 1320

TTTGAAGATA TGAGGAAAGT AGTCTGTGTG GATCAACAGA GGCCAAACAT ACCCAACAGA 1380

TGGTTCTCAG ACCCGACATT AACCTCTCTG GCCAAGCTAA TGAAAGAATG CTGGTATCAG 1440

AATCCATCCG CAAGACTCAC AGCACTGCGT ATCAAAAAGA CTCTGACCAA AATTGATAAT 1500

TCCCTCGACA AATTGAAAAC TGACTGTTGA 1530

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 328   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013