EKS-CAJ-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	361.5	6.2E-108	12	295	284

Status

Unreviewed

Ensembl Protein

ENSCJAP00000029666

UniProt Accession

F7IRE4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000016093	ENSCJAP00000029666	ENSCJAT00000031346

Organism

Callithrix jacchus

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG 300

PTPGCQLPRP NCPVETLKEQ SNPALATKRK RTDALEQGGL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCTCTGG ACGTGAAGTC TCGGGCGAAG CGCTATGAGA AGCTGGACTT CCTTGGAGAG 60

GGACAGTTTG CCACGGTTTA CAAGGCCAGA GATAAGAATA CCAACCAAAT CGTCGCGATT 120

AAGAAAATCA AACTTGGACA TAGATCAGAA GCTAAAGATG GTATAAATAG AACAGCCTTA 180

AGAGAGATAA AATTATTACA GGAGCTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGACATA AATCTAATAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA TCTAGAGGTT 300

ATAATAAAGG ATAATAGTCT TGTGCTGACA CCATCACACA TCAAAGCCTA CATGCTGATG 360

ACTCTTCAAG GATTAGAATA TTTACATCAA CACTGGATCC TACACAGGGA TCTGAAACCA 420

AACAACCTGT TGCTAGATGA AAATGGAGTT CTAAAACTGG CAGATTTTGG CCTGGCCAAA 480

TCATTTGGGA GCCCCAATAG AGCTTATACA CATCAGGTTG TAACCAGGTG GTATCGGGCC 540

CCTGAGTTAC TATTTGGAGC TAGGATGTAT GGTGTGGGTG TGGACATGTG GGCTGTTGGC 600

TGTATATTAG CAGAGTTACT TCTAAGGGTT CCTTTTTTGC CAGGAGATTC AGACCTTGAT 660

CAGCTAACGA GAATATTTGA AACTTTGGGC ACACCAACTG AGGAACAGTG GCCGGACATG 720

TGTAGTCTTC CAGATTATGT GACATTTAAG AGTTTTCCTG GAATTCCATT GCATCATATC 780

TTCAGTGCAG CAGGAGACGA CTTATTAGAT CTCATACAAG GCTTATTCTT ATTTAATCCA 840

TGTGCTCGAA TTACGGCCAC ACAGGCACTG AAAATGAAGT ATTTCAGTAA TCGGCCAGGG 900

CCAACACCTG GATGTCAGTT GCCAAGACCA AACTGTCCAG TGGAAACCTT AAAGGAGCAA 960

TCAAATCCAG CTTTGGCGAC AAAAAGGAAA AGAACAGATG CCTTGGAACA AGGAGGATTG 1020

CCCAAGAAAC TGATTTTTTA A 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp+y  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ ++++ ++ ldl++ l+ ++p  Ri+a++al+ kyf

Q: 249   FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF  295

         9999999******9999*****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDYVTFKS 240

FPGIPLHHIF SAAGDDLLDL IQGLFLFNPC ARITATQALK MKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013