EKS-CAJ-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	414.3	3.8E-124	145	391	247

Status

Unreviewed

Ensembl Protein

ENSCJAP00000030244

UniProt Accession

F7BAX3;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000016427	ENSCJAP00000030227	ENSCJAT00000031942
ENSCJAG00000016427	ENSCJAP00000030244	ENSCJAT00000031960

Organism

Callithrix jacchus

Functional Description

Protein Length

1028

Protein Sequence
(FASTA)

PQRLGGGSMQ PEEGTGWLLE LLSEVQLQQY FLRLRDDLNV TRLSHFEYVK NEDLEKIGMG 60

RPGQRRLWEA VKRRKALCKR KSWMSKVAVG LSVSVAFPPH FWPQGWGAVS WDPVAFSGNT 120

VLSLAQVLGK DELRWGWRRQ EKSMVLTSGL WEAPEIMAVS VAVKCLKPDV LSQPEAMDDF 180

IREVNAMHSL DHRNLIRLYG VVLIPPMKMV TELAPLGSLL DRLRKHQGHF LLGTLSRYAV 240

QVAEGMGYLE SKRFIHRDLA ARNLLLATRD LVKIGDFGLM RALPQNDDHY VMQEHRKVPF 300

AWCAPESLKT RTFSHASDTW MFGVTLWEMF TYGQEPWIGL NGSQILHKID KEGERLPRPE 360

DCPQDIYNVM VQCWAHKPED RPTFVALRDF LLEAHPTDMR ALQDFEEPDK LHIQMNDVIT 420

VIEGRAENYW WRGQNTRTLC VGPFPRNVVT SVAGLSAQDI SQPLQNSFIH TGHGDSDPRH 480

CWGFPDRIDE LYLGNPMDPP DLLSVELSTS RPTQHLGRVK REPPPRPPQP AFFTQKPTYD 540

PVSEDQDPLS SDFKRLGLRK SGLPRGLWLA KPSARVPGTK AGRGSGAEVT LIDFGEEPVV 600

PALRPYTPSL AQLAMDACSL LDKTPPQSPT RALPRPLHPT PVVDWDARPL PPPPAYDDVA 660

QDEDDFEVCS INSSLVGTGV PAGPSQGETN YAFVPEQARL PPPLEDNLFL LPQGGGKPPS 720

SAQTEEIFQA LQQECMRQLQ VPAGSTAPSP SPGGDDKPQV PPRVPIPPRP TRPHLDLSPA 780

SSGEEETGRW PGPASPPRVP PREPLSPPGS RTPSPLVPPG SSPLPPRLSS SPGKTMPTTQ 840

SFASDPKYAT PQVIQAPGPR ASPCILPIVR DGKKVSSTHY YLLPERPSYL ERYQRFLREA 900

QSPEEPAPLP VPLLLPPPST PAPAAPTATV RPMPQAALDP KANFSTNNSN PGARPPAPRA 960

TARPPQRGCA GDGPEAGRLA DKVQMVEQLF GLGLRPRGEC HKVLEMFDWN LEQAGCHLLG 1020

SWGPAHHK 1028

Nucleotide Sequence
(FASTA)

CCACAGAGGC TCGGAGGCGG CAGCATGCAG CCAGAGGAGG GCACAGGCTG GCTGCTGGAG 60

CTGCTGTCCG AGGTGCAGCT GCAACAGTAC TTCCTGCGGC TCCGAGACGA CCTCAACGTC 120

ACCCGGCTGT CCCACTTTGA GTATGTCAAG AATGAGGACC TGGAGAAGAT TGGCATGGGC 180

CGGCCTGGCC AGCGGCGGCT GTGGGAGGCC GTGAAGAGGA GGAAGGCCTT ATGCAAACGG 240

AAGTCGTGGA TGAGCAAGGT AGCTGTCGGG CTGAGTGTCT CCGTGGCCTT CCCTCCCCAC 300

TTCTGGCCTC AGGGATGGGG GGCTGTCTCT TGGGATCCTG TGGCTTTTTC TGGGAACACT 360

GTCCTGTCCC TTGCCCAGGT TTTAGGGAAG GATGAGTTGC GTTGGGGCTG GCGAAGGCAG 420

GAGAAGAGCA TGGTGCTCAC CTCGGGGCTT TGGGAGGCAC CTGAGATAAT GGCTGTGAGT 480

GTGGCTGTGA AGTGCCTGAA GCCCGATGTG CTGAGCCAGC CAGAAGCCAT GGACGACTTC 540

ATCCGGGAGG TCAACGCCAT GCACTCGCTG GACCACCGAA ACCTCATTCG CCTCTATGGG 600

GTGGTGCTCA TACCACCCAT GAAGATGGTG ACAGAGCTGG CACCTCTGGG ATCGCTGTTG 660

GACCGGCTAC GTAAGCACCA GGGCCACTTC CTCCTGGGGA CTCTGAGCCG CTACGCTGTG 720

CAGGTGGCTG AGGGCATGGG CTACCTGGAG TCCAAGCGCT TTATTCACCG TGACCTGGCT 780

GCCCGCAATC TGCTGTTGGC TACCCGCGAC CTGGTCAAGA TCGGGGACTT TGGGCTGATG 840

CGAGCGCTGC CCCAGAATGA CGACCATTAC GTCATGCAGG AACATCGCAA GGTGCCCTTC 900

GCCTGGTGTG CCCCTGAGAG CCTGAAGACA CGTACCTTCT CCCATGCCAG CGACACCTGG 960

ATGTTCGGGG TGACACTGTG GGAGATGTTC ACCTACGGCC AGGAGCCCTG GATCGGCCTC 1020

AATGGCAGTC AGATCCTGCA TAAGATTGAC AAGGAGGGGG AGCGGCTGCC TCGGCCCGAG 1080

GACTGCCCCC AGGACATCTA CAATGTCATG GTCCAGTGCT GGGCTCACAA GCCAGAGGAC 1140

AGACCTACGT TTGTGGCTCT GCGGGACTTC CTGCTGGAGG CCCATCCCAC TGACATGCGG 1200

GCCCTTCAGG ACTTTGAGGA GCCGGACAAG CTGCACATCC AGATGAATGA CGTCATCACT 1260

GTCATCGAGG GAAGGGCCGA GAACTACTGG TGGCGTGGTC AGAACACGCG GACGCTGTGT 1320

GTGGGGCCTT TCCCTCGCAA CGTGGTGACC TCCGTGGCTG GCCTGTCCGC CCAGGACATC 1380

AGCCAACCCC TGCAGAACAG CTTCATCCAC ACGGGGCATG GTGACAGCGA CCCCCGCCAC 1440

TGCTGGGGCT TCCCAGACAG GATCGATGAG CTGTATCTGG GAAACCCCAT GGACCCCCCG 1500

GACCTGCTGA GCGTGGAACT GAGCACCTCC CGGCCCACCC AGCATCTAGG AAGGGTGAAA 1560

AGGGAGCCTC CACCTCGCCC ACCTCAGCCT GCCTTCTTCA CTCAGAAACC AACCTATGAC 1620

CCTGTGAGCG AGGACCAAGA CCCCCTGTCC AGTGACTTCA AGAGGCTGGG CCTTCGGAAG 1680

TCAGGCCTGC CCCGAGGGCT GTGGCTGGCA AAGCCCTCAG CGAGGGTGCC AGGCACCAAG 1740

GCCGGCCGAG GCAGCGGGGC TGAGGTCACG CTCATCGACT TCGGTGAGGA GCCCGTGGTC 1800

CCGGCCCTGC GGCCCTACAC ACCCTCCCTG GCGCAGCTGG CCATGGATGC CTGCTCTTTG 1860

CTAGACAAGA CCCCGCCTCA GAGCCCCACG AGGGCGCTGC CCCGGCCCCT GCATCCCACG 1920

CCTGTGGTGG ACTGGGACGC ACGCCCGCTG CCACCCCCGC CTGCTTATGA CGATGTGGCC 1980

CAGGATGAGG ATGACTTTGA GGTCTGCTCC ATCAACAGCA GCCTGGTGGG CACAGGGGTC 2040

CCTGCTGGAC CCAGCCAGGG CGAGACCAAC TACGCCTTTG TGCCTGAACA GGCACGGCTG 2100

CCCCCTCCCC TGGAGGACAA CCTGTTCCTC CTGCCCCAGG GTGGGGGCAA GCCGCCCAGC 2160

TCTGCGCAGA CCGAGGAGAT CTTCCAGGCT CTGCAGCAGG AGTGCATGCG GCAGCTGCAG 2220

GTTCCGGCCG GATCCACGGC CCCCTCCCCC AGCCCGGGGG GTGACGACAA GCCCCAGGTG 2280

CCCCCTAGGG TGCCCATCCC CCCTCGGCCA ACGCGCCCGC ACCTCGACTT GTCTCCAGCC 2340

TCCTCAGGCG AGGAGGAGAC CGGCCGGTGG CCTGGACCTG CCTCCCCTCC CCGAGTGCCT 2400

CCCCGGGAGC CCCTGTCCCC TCCAGGCTCG AGGACACCCA GCCCCCTGGT ACCACCTGGC 2460

AGCTCCCCAC TGCCGCCCCG GCTCTCAAGC TCACCCGGGA AGACCATGCC TACCACCCAA 2520

AGCTTCGCCT CAGACCCCAA GTACGCCACC CCTCAGGTGA TCCAGGCGCC TGGCCCACGG 2580

GCCAGTCCCT GCATCCTGCC CATCGTCCGG GATGGCAAGA AGGTCAGCAG CACCCACTAT 2640

TACTTGCTGC CTGAGCGCCC GTCCTACCTG GAGCGCTACC AGCGCTTCCT GCGTGAGGCC 2700

CAGAGCCCCG AGGAGCCAGC CCCCCTGCCT GTGCCCCTGC TGCTGCCCCC ACCCAGCACC 2760

CCAGCCCCTG CTGCCCCCAC GGCCACCGTT CGGCCGATGC CCCAGGCTGC CTTGGACCCC 2820

AAAGCCAACT TCTCCACCAA CAACAGCAAC CCAGGGGCCC GGCCACCAGC CCCGAGGGCC 2880

ACTGCTCGGC CGCCACAGCG GGGCTGCGCT GGGGATGGGC CAGAGGCGGG CCGGCTGGCA 2940

GACAAGGTCC AGATGGTGGA GCAGCTCTTC GGGCTGGGTC TGCGGCCCAG AGGGGAGTGC 3000

CACAAAGTGC TGGAGATGTT CGACTGGAAC CTCGAGCAGG CCGGTTGCCA CCTTCTGGGC 3060

TCCTGGGGCC CTGCCCACCA CAAGTGA 3087

Domain Profile

S: 14    vvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllklehenlvrlyGvvlt  72

         v+  g W+ap    v+vavk+lk+d+l+++e+ ddf+rev+++++l+h+nl+rlyGvvl

Q: 145   VLTSGLWEAPEIMAVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDHRNLIRLYGVVLI  204

         67789**************************99***************************

S: 73    qplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayleskrlvhrdlaar  132

          p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yleskr++hrdlaar

Q: 205   PPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAAR  262

         ***********************9..9*********************************

S: 133   nlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtrkfssasdvWaf  192

         nllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+tr+fs+asd+W+f

Q: 263   NLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMF  322

         ************************************************************

S: 193   GvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslllkcWakkpadrp  252

         GvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++++cWa+kp+drp

Q: 323   GVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRP  382

         ************************************************************

S: 253   kfsalkekl  261

         +f+al+++l

Q: 383   TFVALRDFL  391

         ******986

Domain Sequence
(FASTA)

VLTSGLWEAP EIMAVSVAVK CLKPDVLSQP EAMDDFIREV NAMHSLDHRN LIRLYGVVLI 60

PPMKMVTELA PLGSLLDRLR KHQGHFLLGT LSRYAVQVAE GMGYLESKRF IHRDLAARNL 120

LLATRDLVKI GDFGLMRALP QNDDHYVMQE HRKVPFAWCA PESLKTRTFS HASDTWMFGV 180

TLWEMFTYGQ EPWIGLNGSQ ILHKIDKEGE RLPRPEDCPQ DIYNVMVQCW AHKPEDRPTF 240

VALRDFL 247

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013