EKS-CAJ-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	441.4	1.9E-132	247	497	251

Status

Unreviewed

Ensembl Protein

ENSCJAP00000030640

UniProt Accession

F7B7A6;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000016635	ENSCJAP00000030644	ENSCJAT00000032381
ENSCJAG00000016635	ENSCJAP00000030640	ENSCJAT00000032377

Organism

Callithrix jacchus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKGKD SLNDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVSESQL LPGQRFQTKD 60

PEEHGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNSA GSFLIRESET LKGSFSLSVR DFDPVHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVESCPD ELYDIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AGGGAAAGAC AGCTTGAATG ACGATGGAGT AGATTTGAAG 60

ACTCAACCAG TACGTAATAC TGAAAGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAG 120

CAGCAAAGGC CAGTTTCAGA ATCTCAGCTT TTGCCTGGAC AGAGGTTTCA AACTAAAGAT 180

CCGGAGGAGC ATGGAGACAT CGTGGTAGCC TTGTACCCCT ATGATGGCAT CCACCCAGAT 240

GACCTGTCTT TCAAGAAAGG AGAGAAGATG AAAGTCCTGG AGGAGCATGG AGAATGGTGG 300

AAAGCGAAGT CCCTTTTAAC AAAGAAAGAA GGCTTCATCC CCAGCAACTA TGTGGCCAAA 360

GTCAACACCT TAGAGACAGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA GGACGCTGAA 420

AGGCAGCTTT TGGCACCGGG AAATAGCGCT GGATCTTTCC TTATTAGAGA AAGTGAAACC 480

TTAAAAGGAA GCTTCTCTCT GTCTGTCAGA GACTTTGACC CCGTGCACGG CGATGTTATT 540

AAGCACTACA AAATTAGAAG CTTGGACAAC GGGGGCTACT ACATCTCTCC ACGGATCACG 600

TTTCCCTGTA TCAGCGACAT GATCAAACAT TACCAAAAGC AGTCAGATGG CTTGTGCAGA 660

AGACTAGAGA AGGCTTGTAT CAGTCCCAAG CCCCAGAAGC CATGGGATAA AGATGCCTGG 720

GAGATCCCCC GGGAGTCCAT CAAGTTGGTG AAACGGCTCG GCGCTGGGCA GTTTGGAGAA 780

GTCTGGATGG GTTACTATAA CAACAGTACC AAGGTGGCTG TGAAAACCCT GAAGCCGGGC 840

ACGATGTCTG TGCAAGCCTT CCTGGAAGAA GCCAACCTCA TGAAGACTCT GCAGCATGAC 900

AAGCTCGTGA GGCTCTACGC CGTGGTCACC AGGGAGGAGC CTATTTACAT CATTACTGAG 960

TACATGGCCA AGGGCAGTTT GCTGGATTTC CTGAAGAGCG ACGAAGGTGG CAAAGTGCTG 1020

CTTCCAAAGC TCATTGACTT TTCTGCTCAG ATTGCAGAGG GAATGGCGTA CATCGAGCGG 1080

AAGAACTACA TTCACCGGGA CCTACGAGCG GCTAATGTCC TGGTCTCTGA GTCACTCATG 1140

TGCAAAATTG CAGATTTTGG CCTTGCTAGA GTAATTGAAG ATAATGAGTA CACAGCAAGG 1200

GAAGGTGCTA AGTTCCCTAT TAAGTGGACG GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260

ACTATTAAGT CTGATGTGTG GTCCTTTGGA ATTCTCCTAT ACGAAATTGT CACCTATGGG 1320

AAAATTCCCT ACCCAGGGAG AACAAATGCC GATGTGATGA CCGCCCTGTC CCAGGGCTAC 1380

AGGATGCCCC GCGTGGAGAG CTGCCCCGAT GAGCTCTATG ACATCATGAA AATGTGCTGG 1440

AAAGAAAAGG CAGAAGAGAG ACCAACGTTT GATTACTTAC AGAGCGTCCT GGATGATTTC 1500

TACACGGCCA CGGAAGGGCA GTACCAGCAG CAGCCTTAG 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr e+cp+ely+++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVESCPDELYDIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRVE SCPDELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013